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GB860292A - Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them - Google Patents

Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them

Info

Publication number
GB860292A
GB860292A GB15197/58A GB1519758A GB860292A GB 860292 A GB860292 A GB 860292A GB 15197/58 A GB15197/58 A GB 15197/58A GB 1519758 A GB1519758 A GB 1519758A GB 860292 A GB860292 A GB 860292A
Authority
GB
United Kingdom
Prior art keywords
cation
alkyl group
compound
acid
inert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15197/58A
Inventor
John Harold Chapman
William Graham
Ronald Major Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB15197/58A priority Critical patent/GB860292A/en
Priority to DEG27041A priority patent/DE1115414B/en
Priority to FR794500A priority patent/FR1324208A/en
Publication of GB860292A publication Critical patent/GB860292A/en
Priority to US261517A priority patent/US3218349A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0860292/IV (b)/1> (wherein R is a hydrogen atom, an inert cation or a C1-6 alkyl group), and the preparation of: (1) the free acid by reacting a hypobromite or hypochlorite with tetraiodophthalamic acid or a salt thereof, which may be made from ammonia and tetraiodophthalic anhydride; and (2) the esters above by esterifying tetraiodoanthranilic or a metal salt thereof. An "inert cation" is a cation that does not appreciably affect the pharmaceutical characteristics of the compound to which it is attached. According to the Provisional Specification, R, when an alkyl group, may be substituted by bromine or chlorine atoms, hydroxyl, alkoxy or nitro groups.ALSO:Broncographic compositions comprise a compound of the general formula <FORM:0860292/VI/1> (wherein R is a hydrogen atom, an inert cation or a C1-6 alkyl group) in an aqueous or oily liquid medium. They may be administered in any convenient way. An "inert cation" is a cation that does not appreciably affect the pharmaceutical characteristics of the compound to which it is attached. According to the Provisional Specification, R, when an alkyl group, may be substituted by bromine or chlorine atoms, hydroxyl, alkoxy or nitro groups.
GB15197/58A 1958-05-12 1958-05-12 Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them Expired GB860292A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB15197/58A GB860292A (en) 1958-05-12 1958-05-12 Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them
DEG27041A DE1115414B (en) 1958-05-12 1959-05-12 X-ray contrast media
FR794500A FR1324208A (en) 1958-05-12 1959-05-12 New iodine derivatives of anthranilic acid, their preparation process and their applications as contrast agents
US261517A US3218349A (en) 1958-05-12 1963-02-27 Esters of tetraiodoanthranilic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15197/58A GB860292A (en) 1958-05-12 1958-05-12 Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them

Publications (1)

Publication Number Publication Date
GB860292A true GB860292A (en) 1961-02-01

Family

ID=10054749

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15197/58A Expired GB860292A (en) 1958-05-12 1958-05-12 Tetraiodoanthranilic acid and derivatives thereof, and their preparation and compositions containing them

Country Status (3)

Country Link
US (1) US3218349A (en)
DE (1) DE1115414B (en)
GB (1) GB860292A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689630A (en) * 1968-09-09 1972-09-05 Sakai Chemical Industry Co Barium sulfate contrast media
US3855405A (en) * 1969-11-26 1974-12-17 Squibb & Sons Inc Radiographic contrast composition containing 2{40 ,6{40 -diiodo-dl-thyronine and methods of use thereof
US3984571A (en) * 1970-03-10 1976-10-05 E. R. Squibb & Sons, Inc. Hydrocolloid containing liquid carrier for a diagnostic or therapeutic agent
DE3106111A1 (en) * 1981-02-19 1982-09-09 Hoechst Ag, 6000 Frankfurt METHOD FOR PRODUCING AROMATIC AMINOCARBONIC ACID ALKYL ESTERS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB517382A (en) * 1938-07-25 1940-01-29 Douglas John Branscombe Manufacture of iodinated esters
CH276619A (en) * 1949-02-14 1951-07-15 Cilag Ag Process for the preparation of a new derivative of p-amino-salicylic acid.
US2611786A (en) * 1950-05-31 1952-09-23 Mallinckrodt Chemical Works 3-carboxylic acylamino-2, 4, 6-triiodo benzoic acids and the ethyl ester and nontoxic salts
US2813118A (en) * 1953-07-16 1957-11-12 American Cystoscope Makers Inc X-ray contrast compounds
US3014033A (en) * 1958-03-26 1961-12-19 Glaxo Lab Ltd Derivatives of tetraiodophthalamic acid
US3026351A (en) * 1958-09-19 1962-03-20 Mallinckrodt Chemical Works Iodo-benzoic acid compounds

Also Published As

Publication number Publication date
DE1115414B (en) 1961-10-19
US3218349A (en) 1965-11-16

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