GB835842A - New biologically active compounds from oleaceae and process for the preparation thereof - Google Patents
New biologically active compounds from oleaceae and process for the preparation thereofInfo
- Publication number
- GB835842A GB835842A GB7424/58A GB742458A GB835842A GB 835842 A GB835842 A GB 835842A GB 7424/58 A GB7424/58 A GB 7424/58A GB 742458 A GB742458 A GB 742458A GB 835842 A GB835842 A GB 835842A
- Authority
- GB
- United Kingdom
- Prior art keywords
- elenolic acid
- acid
- elenolic
- organic solvent
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises salts of elenolic acid of general formula (C11H13O6)nM, where M i sodium, potassium, ammonium, calcium, magnesium, zinc or ferrous iron and n is the valency of M; ethers of elenolic acid and its esters of general formula C11H13O6R and C11H12O6(R)2 respectively, where R is an alkyl group of less than six carbon atoms; and a process for the preparation of elenolic acid concentrates by extracting parts of plants of the Oleaceae family with a water-immiscible organic solvent, separating the neutral constituents from the extract by evaporation to dryness, solution of the residue in an aqueous bicarbonate solution of pH 7-7.5, and solvent extraction, whereafter the elenolic acid portion is isolated by acidification of the aqueous phase and extraction with a water-immiscible solvent, e.g. chloroform or ether. Detailed examples illustrate the extraction of elenolic acid from Olea europea and the preparation of its salts, elenolide, and the methyl and ethyl ethers of elenolic acid and its methyl and ethyl esters.ALSO:Concentrates of elenolic acid, C11H14O6 are prepared by extracting parts of plants of the Oleaceae family with a non-water miscible organic solvent, removing the neutral constituents from the extract by evaporating it to dryness, treating an aqueous solution of the residue with bicarbonate (to pH 7-7.5) adding a water-soluble salt, and extracting with a non-water miscible organic solvent, then acidifying the aqueous phase and extracting the elenolic acid with a non-water miscible organic solvent, e.g. chloroform or ether. Elenolic acid, its salts, e.g. magnesium, calcium, zinc, ferrous, ammonium sodium and potassium, elenolide, and acetals and acetalesters of elenolic acid are hypotensive agents which may be administered orally, as suspensions or solutions but preferably in solid form coated against the action of gastric acid, parenterally as an aqueous solution suitable for injection, or by incorporation in suppositories.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL835842X | 1957-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB835842A true GB835842A (en) | 1960-05-25 |
Family
ID=19843135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7424/58A Expired GB835842A (en) | 1957-04-13 | 1958-03-07 | New biologically active compounds from oleaceae and process for the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB835842A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2081341A2 (en) * | 1969-12-11 | 1971-12-03 | Upjohn Co | Elenolic acid derivs as antivirals |
| EP1588710A1 (en) * | 2004-04-06 | 2005-10-26 | Shinto Fine Co., Ltd. | Anti-allergic composition and method for denaturing allergens |
-
1958
- 1958-03-07 GB GB7424/58A patent/GB835842A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2081341A2 (en) * | 1969-12-11 | 1971-12-03 | Upjohn Co | Elenolic acid derivs as antivirals |
| EP1588710A1 (en) * | 2004-04-06 | 2005-10-26 | Shinto Fine Co., Ltd. | Anti-allergic composition and method for denaturing allergens |
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