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GB759314A - Improvements in or relating to the manufacture of alkaloids - Google Patents

Improvements in or relating to the manufacture of alkaloids

Info

Publication number
GB759314A
GB759314A GB20007/54A GB2000754A GB759314A GB 759314 A GB759314 A GB 759314A GB 20007/54 A GB20007/54 A GB 20007/54A GB 2000754 A GB2000754 A GB 2000754A GB 759314 A GB759314 A GB 759314A
Authority
GB
United Kingdom
Prior art keywords
aqueous
reserpine
separation
alkaloids
chloroform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20007/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
S B Penick & Co
Original Assignee
S B Penick & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S B Penick & Co filed Critical S B Penick & Co
Publication of GB759314A publication Critical patent/GB759314A/en
Expired legal-status Critical Current

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  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Alkaloidal extracts of Rauwolfia species are treated with a mixture of halogenated aliphatic hydrocarbon and an aqueous acid of pH below 2.5, the two phases separated and the alkaloids recovered therefrom. The starting material can be made by treating the ground wetted plants with benzene and concentrating the resulting extract. Preferred solvents for the separation are chloroform and aqueous orthophosphoric acid of pH 0.6-1.5. Reserpine can be obtained from the chloroform phase by washing with aqueous alkali, evaporating to dryness and recrystallizing from a lower alcohol such as methanol. Examples show the separation of reserpine from R. serpentine and R. micrantha, and it is stated that R. heterophylla, R. vomitoria, R. perakensis and R. hirsuta may also be used. Other suitable solvents are carbon tetrachloride, ethylene dichloride, trichlorethylene and tetrachlorethylene on the one hand and hydrochloric, sulphuric and acetic acids on the other.
GB20007/54A 1954-03-01 1954-07-08 Improvements in or relating to the manufacture of alkaloids Expired GB759314A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US759314XA 1954-03-01 1954-03-01

Publications (1)

Publication Number Publication Date
GB759314A true GB759314A (en) 1956-10-17

Family

ID=22128836

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20007/54A Expired GB759314A (en) 1954-03-01 1954-07-08 Improvements in or relating to the manufacture of alkaloids

Country Status (1)

Country Link
GB (1) GB759314A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876228A (en) * 1956-11-27 1959-03-03 Pfizer & Co C Recovery of rescinnamine
US2948729A (en) * 1958-01-17 1960-08-09 S B Penick And Company Purification of weakly basic alkaloids by the use of naphthoate salts
DE1099545B (en) * 1957-04-15 1961-02-16 Ciba Geigy Process for the production of alkaloids of the raunescein group
DE1134386B (en) * 1958-09-30 1962-08-09 Dresden Arzneimittel Process for obtaining the total Rauwolfia alkaloids
DE1170783B (en) * 1960-04-23 1964-05-21 Walter Eisbein Dr Ing Photocopier
DE1282022B (en) * 1963-09-16 1968-11-07 Dresden Arzneimittel Process for the production of rescinnamine

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876228A (en) * 1956-11-27 1959-03-03 Pfizer & Co C Recovery of rescinnamine
DE1099545B (en) * 1957-04-15 1961-02-16 Ciba Geigy Process for the production of alkaloids of the raunescein group
US2948729A (en) * 1958-01-17 1960-08-09 S B Penick And Company Purification of weakly basic alkaloids by the use of naphthoate salts
DE1232589B (en) * 1958-01-17 1967-01-19 S B Penick And Company Process for obtaining the weakly basic Rauwolfia alkaloids reserpine, deserpidine, rescinnamine, raunescin and isoraunescin
DE1134386B (en) * 1958-09-30 1962-08-09 Dresden Arzneimittel Process for obtaining the total Rauwolfia alkaloids
DE1170783B (en) * 1960-04-23 1964-05-21 Walter Eisbein Dr Ing Photocopier
DE1282022B (en) * 1963-09-16 1968-11-07 Dresden Arzneimittel Process for the production of rescinnamine

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