GB835557A - New steroid compounds and the preparation thereof - Google Patents
New steroid compounds and the preparation thereofInfo
- Publication number
- GB835557A GB835557A GB18246/56A GB1824656A GB835557A GB 835557 A GB835557 A GB 835557A GB 18246/56 A GB18246/56 A GB 18246/56A GB 1824656 A GB1824656 A GB 1824656A GB 835557 A GB835557 A GB 835557A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pregnene
- dione
- diester
- preparation
- diacetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
the invention comprises 9a - halo - 16a - hydroxy-hydrocortisones of the general formula <FORM:0835557/IV (b)/1> wherein R and R1 are either both hydrogen or both alkanoyl radicals containing 1/6 carbon atoms and Hal represents a halogen, and the preparation thereof by reacting the required diester of D 4 - pregnene - 16a ,17a ,21 - triol - 3,20 - dione - 9b ,11b - oxide with hydrogen halide, and if required, saponifying the diester formed. The reaction with the hydrogen halide is preferably carried out at a temperature of from - 10 DEG to 15 DEG C., a suitable reaction solvent being a halogenated hydrocarbon such as chloroform or carbon tetrachloride. The process may be modified in that the diester reactant is prepared by reacting the required D 4 - pregnene - 9a - bromo - 11b ,16a ,17a 21tetrol - 3,20 - dione - 16a ,21 - diester with an anhydrous alkali metal acetate, e.g. potassium acetate. In the examples, D 4-pregnene-9a -fluoro - 11b ,16a ,17a ,21 - tetrol - 3,20 - dione and the corresponding 16a ,21-diacetate and D 4-pregnene - 9a - chloro - 11b ,16a ,17a ,21 - tetrol3,20-dione and the corresponding 16a ,21-diacetate are prepared. Specification 835,558 is referred to.ALSO:A therapeutic composition which may be used internally or topically contains as the active ingredient 9a - fluoro - 16a - hydro-cortisone. The composition may be in the form of a capsule, pill, tablet, ointment, salve or injectable solution. Specification 835,558 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US835557XA | 1955-06-30 | 1955-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB835557A true GB835557A (en) | 1960-05-25 |
Family
ID=22179092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18246/56A Expired GB835557A (en) | 1955-06-30 | 1956-06-13 | New steroid compounds and the preparation thereof |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB835557A (en) |
| MY (1) | MY6300024A (en) |
-
1956
- 1956-06-13 GB GB18246/56A patent/GB835557A/en not_active Expired
-
1963
- 1963-12-31 MY MY196324A patent/MY6300024A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY6300024A (en) | 1963-12-31 |
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