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GB834692A - Process for the preparation of bis-testosterone and the 17-acetate thereof - Google Patents

Process for the preparation of bis-testosterone and the 17-acetate thereof

Info

Publication number
GB834692A
GB834692A GB20719/57A GB2071957A GB834692A GB 834692 A GB834692 A GB 834692A GB 20719/57 A GB20719/57 A GB 20719/57A GB 2071957 A GB2071957 A GB 2071957A GB 834692 A GB834692 A GB 834692A
Authority
GB
United Kingdom
Prior art keywords
testosterone
acetate
cis
tosylate
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20719/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB834692A publication Critical patent/GB834692A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The 17-acetate of cis-testosterone is prepared by reacting an alkali metal acetate with the 17-tosylate of trans-testosterone in the presence of a N-alkyl-disubstituted aliphatic carboxylic acid amide containing a total of up to 8 carbon atoms. The above process may be modified in that the 17-acetate of cis-testosterone is saponified to form cis-testosterone. Suitable amides are dimethylformamide and dimethylacetamide. The reaction may be carried out at elevated temperatures, e.g. at the boiling point of the reaction mixture. Potassium or sodium acetate may be used as the alkali metal acetate. One detailed example is given. 17-Tosylate of trans-testosterone is prepared by reacting testosterone and tosyl chloride in the presence of pyridine. Specification 822,205 is referred to.
GB20719/57A 1956-07-18 1957-07-01 Process for the preparation of bis-testosterone and the 17-acetate thereof Expired GB834692A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR834692X 1956-07-18

Publications (1)

Publication Number Publication Date
GB834692A true GB834692A (en) 1960-05-11

Family

ID=9297281

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20719/57A Expired GB834692A (en) 1956-07-18 1957-07-01 Process for the preparation of bis-testosterone and the 17-acetate thereof

Country Status (1)

Country Link
GB (1) GB834692A (en)

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