GB829260A - Preparation of steroid compounds - Google Patents
Preparation of steroid compoundsInfo
- Publication number
- GB829260A GB829260A GB2949/58A GB294958A GB829260A GB 829260 A GB829260 A GB 829260A GB 2949/58 A GB2949/58 A GB 2949/58A GB 294958 A GB294958 A GB 294958A GB 829260 A GB829260 A GB 829260A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dione
- hydroxypregnane
- steroid
- allopregnane
- pregnane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises a process for the preparation of steroid compounds by contacting a 3-keto nuclear saturated steroid having from 18-21 atoms in the carbon skeleton with oxidizing enzymes of an organism of the genus Nocardia, and thereby producing a 3-keto- D 1,4steroid, a 3-keto- D 4-steroid or mixtures thereof. As species of the genus Nocardia there may be used N. convoluta, N. corallina, N. erythropolis, N. gardneri, N. minima, N. polychromegenes, N. opaca and N. globerula. As starting materials there are mentioned androstene-3-one, androstane-3,17-dione, bisnorcholane - 3 - one, pregnane - 3 - one, pregnane - 3,20-dione, 4-dihydrocorticosterone, 17a -hydroxyandrostane-3-one, estrane-3-one, 4-dihydrodesoxycorticosterone, allopregnane-3-one, allopregnane-3,20-dione, 17a -hydroxypregnane-3-one and 3,20-dion, 11b -hydroxypregnane-3-one and 3,20-dione, 20-hydroxypregnane-3-one, 14a -hydroxypregnane-3-one and 3,20-dione, pregnane and allopregnane - 3,11,20 - trione, 11b ,17a ,21 - trihydroxypregnane-3,20-dione, 17,21 - dihydroxypregnane - 3,11,20 - trione, 11b ,21 - dihydroxypregnane - 3,20 - dione, 11b ,14a ,17a ,21 - tetrahydroxypregnane - 3,20 - dione and 21-hydroxypregnane-3,20-dione. The oxidation of the steroid compound may be effected in the presence of the whole fermentation product, by cells removed from the growing culture and resuspended, or by oxidizing enzymes prepared from cells of the organism. Examples describe the preparation of prednisolone, prednisone, D 1,4-pregnadiene-21-ol-3,20-dione, desoxycorticosterone, and D 1,4-desoxycorticosterone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US829260XA | 1957-02-12 | 1957-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB829260A true GB829260A (en) | 1960-03-02 |
Family
ID=22174337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2949/58A Expired GB829260A (en) | 1957-02-12 | 1958-01-29 | Preparation of steroid compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB829260A (en) |
-
1958
- 1958-01-29 GB GB2949/58A patent/GB829260A/en not_active Expired
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