Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25959/57A
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GD Searle LLC
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GD Searle LLC
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Publication date
Application filed by GD Searle LLCfiledCriticalGD Searle LLC
Publication of GB822595ApublicationCriticalpatent/GB822595A/en
C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Health & Medical Sciences
(AREA)
General Health & Medical Sciences
(AREA)
Steroid Compounds
(AREA)
Abstract
The invention comprises 17a -methyl-17-hydroxy-5(10)-estren-3-one. The compound may be prepared by the mild acidic hydrolysis of a 3-alkoxy-17a -methyl-2,5(10)-estradien-17-ol. In the example, the compound is prepared by the mild hydrolysis of 17a -methyl-3-methoxy-2,5(10)-estradien-17-ol with acetic acid dissolved in methanol. 17a - Methyl - 3 - methoxy - 2,5(10) - estradien-17-ol is prepared by treating a solution of 17a -methyl - 3 - methoxy - 1,3,5(10) - estratrien-17-ol in ether and liquid ammonia with lithium.
A process for converting nitrosyl chloride in nitrogen oxide and an aqueous solution of acids (Machine-translation by Google Translate, not legally binding)
Procedure and device for the functioning of a combustión engine of various cycles of two cycles (Machine-translation by Google Translate, not legally binding)