GB808950A - Novel sulphanilamido-isoxazole derivatives and a process for the manufacture thereof - Google Patents
Novel sulphanilamido-isoxazole derivatives and a process for the manufacture thereofInfo
- Publication number
- GB808950A GB808950A GB28763/57A GB2876357A GB808950A GB 808950 A GB808950 A GB 808950A GB 28763/57 A GB28763/57 A GB 28763/57A GB 2876357 A GB2876357 A GB 2876357A GB 808950 A GB808950 A GB 808950A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphanilamido
- isoxazole
- lead
- dimethyl
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0808950/IV (b)/1> wherein R is an alkyl (preferably lower alkyl), aralkyl or cycloalkyl group, and their preparation by reacting a metal salt of 3:4-dimethyl-5-sulphanilamido-isoxazole with an alkyl, aralkyl or cycloalkyl haloformate, preferably in an organic solvent and in the presence of a tertiary nitrogen base. The metal salt of the sulphanilamido-isoxazole is preferably a heavy metal salt such as a lead or silver salt. Examples describe the reaction of the lead or silver salt of 3:4 - dimethyl - 5 - sulphanilamido - isoxazole with the appropriate chloroformic ester to give compounds of the above general formula in which R is an ethyl, methyl, octyl, benzyl and cyclohexyl group. Chloroformic esters used as starting materials such as the octyl, benzyl and cyclohexyl esters are made by the reaction of phosgene with the appropriate alcohol. 3:4 - Dimethyl - 5 - sulphanilamido - isoxazole silver and lead salts are made by the action of silver nitrate and lead sub-acetate respectively on the sulphanilamido-isoxazole in aqueous solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28763/57A GB808950A (en) | 1957-09-12 | 1957-09-12 | Novel sulphanilamido-isoxazole derivatives and a process for the manufacture thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28763/57A GB808950A (en) | 1957-09-12 | 1957-09-12 | Novel sulphanilamido-isoxazole derivatives and a process for the manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB808950A true GB808950A (en) | 1959-02-11 |
Family
ID=22160323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28763/57A Expired GB808950A (en) | 1957-09-12 | 1957-09-12 | Novel sulphanilamido-isoxazole derivatives and a process for the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB808950A (en) |
-
1957
- 1957-09-12 GB GB28763/57A patent/GB808950A/en not_active Expired
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