GB799343A - Preparation of steroid compounds - Google Patents
Preparation of steroid compoundsInfo
- Publication number
- GB799343A GB799343A GB23574/56A GB2357456A GB799343A GB 799343 A GB799343 A GB 799343A GB 23574/56 A GB23574/56 A GB 23574/56A GB 2357456 A GB2357456 A GB 2357456A GB 799343 A GB799343 A GB 799343A
- Authority
- GB
- United Kingdom
- Prior art keywords
- progesterone
- dione
- keto
- hydroxyhydrocortisone
- pregnadiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
D 1,4-3-keto-steroids are obtained by contacting a 3-keto-steroid having conjugated with said keto group one A ring double bond, with selenium dioxide at an elevated temperature in an inert organic solvent. As starting compounds there may be used cortisone, hydrocortisone, progesterone, desoxycorticosterone, corticosterone, 14-hydroxycortisone, 14-hydroxyhydrocortisone, 14 - hydroxy - 15 - bromocortisone, 14,15 - dihydroxyhydrocortisone, 9a -fluorocortisone, 9a - bromohydrocorisone, D 6-progesterone, D 14 - dehydrocortisone, D 9(11)-progesterone, 9 - hydroxyhydrocortisone and esters of those compounds having a 21-hydroxy group, e.g. the benzoates, acetates, propionates, butyrates and phthalates. As solvents there may be used ethylene glycol diethers, phenetole, xylene, dioxane and naphthalene. The addition of pyridine, dimethylaniline, diethylaniline, N - propylaniline, N - propyltoluidine, or dimethyltoluidine prevents decomposition of both the starting compounds and the produc.ts Examples disclose the preparation of D 1,4-pregnadiene - 3,20 - dione - 17a ,21 - diol acetate, D 1-dehydrocortisone acetate, D 1,4 - 9 - chloro-11,17,21 - trihydroxy - pregnadiene - 3,20-dione, D 1,4 - androstadiene - 3,17 - dione, D 1,4,7,22 ergostateraene - 3 - one, and D 1,4 - cholestadiene-3-one.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US799343XA | 1955-08-05 | 1955-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB799343A true GB799343A (en) | 1958-08-06 |
Family
ID=22153744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23574/56A Expired GB799343A (en) | 1955-08-05 | 1956-07-31 | Preparation of steroid compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB799343A (en) |
-
1956
- 1956-07-31 GB GB23574/56A patent/GB799343A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB799343A (en) | Preparation of steroid compounds | |
| GB1045979A (en) | Improvements in or relating to 5,10-seco-5,19-cyclo-10-fluoro-steroids | |
| GB959378A (en) | 21-substituted 17ª, 21-dioxy steroids and processes for their preparation | |
| GB1037891A (en) | Process for the manufacture of 19-nor-steroids | |
| GB824348A (en) | Process for preparing steroid compounds | |
| GB892620A (en) | Cyclopentanophenanthrene derivatives | |
| GB843108A (en) | Process for the preparation of cyclopentanophenanthrene derivatives | |
| GB1520356A (en) | 11-12-unsaturated-9-fluoro-steroids and a process for the-eir manufacture | |
| GB777996A (en) | Steriod compounds and their preparation | |
| GB814878A (en) | Steroid compounds and the preparation thereof | |
| ES360114A1 (en) | New steroid derivatives | |
| GB825210A (en) | Dehydro-compounds of the steroid series and process for their manufacture | |
| GB923125A (en) | Steroid compounds | |
| GB992147A (en) | Improvements in or relating to 3-keto-í¸-steroids | |
| GB957436A (en) | 16ª‡-halomethyl-derivatives of steroids of the 17ª‡-hydroxy-pregnane series and a process for their manufacture | |
| US3029259A (en) | 9alpha-halo-4-pregnene-3, 20 diones and derivatives thereof | |
| GB1008274A (en) | Process for the manufacture of steroid-dienes | |
| GB862701A (en) | A process for the preparation of 9ª‡-hydroxy steroids | |
| GB765888A (en) | Selective reduction of ketosteroids with yeast | |
| GB773926A (en) | Improvements relating to pregnane compounds | |
| GB723749A (en) | Steroids | |
| GB1119081A (en) | New steroids | |
| GB830921A (en) | í¸-steroids and their preparation by a microbiological process | |
| GB918408A (en) | Esters of 21-hydroxy steroids and process for preparation | |
| GB918738A (en) | Improvements in or relating to the preparation of steroid compounds |