Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB861453A
Inventor
Ronald Levin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co LtdfiledCriticalDistillers Co Yeast Ltd
Priority to GB861453ApriorityCriticalpatent/GB744490A/en
Publication of GB744490ApublicationCriticalpatent/GB744490A/en
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procaine penicillin mainly in platelet form is produced by crystallizing the procaine penicillin in the presence of a water-soluble ethyl methyl cellulose ether. Preferably a salt of procaine such as the hydrochloride, phosphate or acetate is reacted with a salt of penicillin such as an amine or metal salt, e.g. the sodium salt, in aqueous solution in the presence of 0.05 to 1 per cent and especially 0.1 per cent (w./v.) of ethyl methyl cellulose ether. The concentration of penicillin in the reaction solution should not exceed 60,000 units per mil. The crystallization may be carried out in the presence of buffers such as sodium citrate and preservatives such as phenyl mercuric nitrate or sodium metabisulphite. Specification 681,140 is referred to.
GB861453A1953-03-281953-03-28Improved process for the production of crystalline procaine penicillin
ExpiredGB744490A
(en)
A procedure for the preparation of aluminum, bismuto and 8-hydroxyquinoline salts of pamoic acid (Machine-translation by Google Translate, not legally binding)