Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB37553A
Inventor
Alan August Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ward Blenkinsop and Co Ltd
Original Assignee
Ward Blenkinsop and Co Ltd
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Filing date
Publication date
Application filed by Ward Blenkinsop and Co LtdfiledCriticalWard Blenkinsop and Co Ltd
Priority to GB37553ApriorityCriticalpatent/GB744307A/en
Publication of GB744307ApublicationCriticalpatent/GB744307A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The invention comprises p - aminosalicylhydroxamic acid of the formula <FORM:0744307/IV(a)/1> and its preparation by reducing p-nitrosalicylhydroxamic acid, obtained by the action of hydroxylamine on an alkyl p-nitrosalicylate, p-nitrosalicylamide or the acid halide of an O-acyl derivative of p-nitrosalicylic acid, the reduction being effected with substantially three molecular proportions of hydrogen in the presence of a hydrogenation catalyst. Suitably the catalyst is a finely-divided metal of Group VIII of the periodic table. In an example ethyl p-nitrosalicylate is treated with hydroxylamine hydrochloride and alkali and the resulting 4-nitrosalicylhydroxami acid is reduced with palladium - charcoal to give 4 - aminosalicylhydroxamic acid.
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