GB727179A - Method of stabilising pure phenothiazine - Google Patents
Method of stabilising pure phenothiazineInfo
- Publication number
- GB727179A GB727179A GB30577/52A GB3057752A GB727179A GB 727179 A GB727179 A GB 727179A GB 30577/52 A GB30577/52 A GB 30577/52A GB 3057752 A GB3057752 A GB 3057752A GB 727179 A GB727179 A GB 727179A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenothiazine
- hexamethylene tetramine
- mixing
- stabilising
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Phenothiazine is stabilized by incorporating hexamethylene tetramine, e.g. by mixing the solids or by mixing the phenothiazine with a solution of hexamethylene tetramine and evaporating off the solvent. The amount of hexamethylene tetramine incorporated is about 0.3 to 3.0 per cent. Examples are given of (1) mixing the phenothiazine and the hexamethylene tetramine in a ball mill; (2) and (3) mixing the phenothiazine with a solution of hexamethylene tetramine in methanol, filtering and drying.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE727179X | 1951-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB727179A true GB727179A (en) | 1955-03-30 |
Family
ID=6635399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30577/52A Expired GB727179A (en) | 1951-12-20 | 1952-12-02 | Method of stabilising pure phenothiazine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB727179A (en) |
-
1952
- 1952-12-02 GB GB30577/52A patent/GB727179A/en not_active Expired
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