GB712387A - A process for the manufacture of riboflavin-5 -phosphoric acid ester - Google Patents
A process for the manufacture of riboflavin-5 -phosphoric acid esterInfo
- Publication number
- GB712387A GB712387A GB30340/52A GB3034052A GB712387A GB 712387 A GB712387 A GB 712387A GB 30340/52 A GB30340/52 A GB 30340/52A GB 3034052 A GB3034052 A GB 3034052A GB 712387 A GB712387 A GB 712387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- riboflavin
- acid ester
- acid
- manufacture
- phosphoric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 10
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 5
- 229960002477 riboflavin Drugs 0.000 abstract 5
- 235000019192 riboflavin Nutrition 0.000 abstract 5
- 239000002151 riboflavin Substances 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65618—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system, e.g. flavins or analogues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
Riboflavin - 51 - monophosphoric acid ester is obtained by reacting riboflavin with metaphosphoric acid, hydrolysing the crude mixture obtained thereby and separating riboflavin-51-monophosphoric acid ester by fractional crystallization and salt formation from the resulting mixture of riboflavin, riboflavin-51-monophosphoric acid ester and riboflavin polyphosphoric acid esters. The phosphorylation may be effected by heating together riboflavin and metaphosphoric acid for 10-15 minutes at about 60 DEG C. and the product hydrolysed by means of aqueous mineral acid. An example is given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH712387X | 1951-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB712387A true GB712387A (en) | 1954-07-21 |
Family
ID=4530853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30340/52A Expired GB712387A (en) | 1951-12-10 | 1952-12-01 | A process for the manufacture of riboflavin-5 -phosphoric acid ester |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB712387A (en) |
-
1952
- 1952-12-01 GB GB30340/52A patent/GB712387A/en not_active Expired
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