GB679215A - Improvements in or relating to sulphanilyl piperazines - Google Patents
Improvements in or relating to sulphanilyl piperazinesInfo
- Publication number
- GB679215A GB679215A GB3600/50A GB360050A GB679215A GB 679215 A GB679215 A GB 679215A GB 3600/50 A GB3600/50 A GB 3600/50A GB 360050 A GB360050 A GB 360050A GB 679215 A GB679215 A GB 679215A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperazine
- sulphanilyl
- piperazines
- carbamyl
- thiocarbamyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises sulphanilyl piperazines of formula <FORM:0679215/IV (b)/1> where R is hydrogen or an aliphatic acyl group, X is oxygen or sulphur, and R1 and R11 are hydrogen or lower alkyl, at least one being lower alkyl. The compounds are prepared by reacting an acyl sulphanilyl halide of the formula <FORM:0679215/IV (b)/2> with a carbamyl or thiocarbamyl piperazine of formula <FORM:0679215/IV (b)/3> and if desired hydrolysing the product. The preferred reaction temperature is 0-30 DEG C. and solvents in which it is preferred to work are chloroform, acetone, carbon tetrachloride, ethyl acetate and water. Examples are given of the preparation of 1 - diethylcarbamyl - 4 - (acetylsulphanilyl) - piperazine, 1 - diethylcarbamyl - 4 - sulphanilylpiperazine, 1-diethylthiocarbamyl-4-(acetylsulphanilyl)-piperazine, and 1-diethylthiocarbamyl-4-sulphanilylpiperazine. The carbamyl and thiocarbamyl piperazines used as intermediates are prepared by reacting a carbamyl or thiocarbamyl halide with piperazine or a hydrate thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US679215XA | 1949-03-30 | 1949-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB679215A true GB679215A (en) | 1952-09-17 |
Family
ID=22079294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3600/50A Expired GB679215A (en) | 1949-03-30 | 1950-02-13 | Improvements in or relating to sulphanilyl piperazines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB679215A (en) |
-
1950
- 1950-02-13 GB GB3600/50A patent/GB679215A/en not_active Expired
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