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Expired
Application number
GB73/42A
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of GB552076ApublicationCriticalpatent/GB552076A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
552,076. α - (4 - Methylphenyl) - # - methylaminopropane. HOFFMAN - LA ROCHE & CO., AKT.-GES., F. Jan. 2, 1942, No. 73. Convention date, March 19, 1941.. [Class 2 (iii)] α - (4 - Methylphenyl) - # - methyl - aminopropane is prepared by reacting 4 - methyl benzyl cyanide with acetic ester in the presence of sodium alcoholate to give α - (4 - methylphenyl) # oxo - butyric acid nitrile, saponifying this compound to 4 - methylphenyl acetone, and then catalytically reducing in the presence of methyl amine in alcohol. The compound has medicinal properties. In an example p - - methyl benzyl cyanide and dry acetic ester are added to a solution of sodium in absolute alcohol. The condensation product crystallises in the form of its sodium salt. On treatment with acetic acid and fractional vacuum distillation α - (4 - methyl phenyl) # oxo - butyric acid nitrile is obtained as an oil. This oil is saponified with sulphuric acid to (4 - methyl phenyl) acetone which is then reduced with hydrogen in the presence of a Raney nickel catalyst with the addition of methyl amine in methyl alcohol.
GB73/42A1941-03-191942-01-02Process for the manufacture of ª‡-(4-methyl-phenyl)-ª‰-methyl-amino-propan
ExpiredGB552076A
(en)