GB526884A - Improvements in or relating to the manufacture of d1-tocopherols - Google Patents
Improvements in or relating to the manufacture of d1-tocopherolsInfo
- Publication number
- GB526884A GB526884A GB8628/39A GB862839A GB526884A GB 526884 A GB526884 A GB 526884A GB 8628/39 A GB8628/39 A GB 8628/39A GB 862839 A GB862839 A GB 862839A GB 526884 A GB526884 A GB 526884A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bromide
- phytyl
- dimethylhydroquinone
- phytol
- tocopherols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
526,884. Tocopherols. HOFFMAN-LA ROCHE & CO. AKT.-GES. F. March 17, 1939, Nos. 8623, 8629, 8630, 8631,8632,8633, 8634 and 8635. Convention dates, March 31, 1938, April 1, 1938, April 14, 1938, June 3, 1938, June 11, 1938, June 23, 1938, July 20, 1938 and July 26, 1938. [Class 2 (iii)] Al-tocopherols are prepared by reacting trimethylhydroquinone or a dimethylhydroquinone with phytol, isophytol, a phytyl halide or a 3-halogeno-dihydrophytyl halide in the presence of an acidic condensing agent. The products, which are chromane derivatives, appear to be identical with the racemates of tocopherols obtained from natural materials and are useful therapeutically. The reaction is preferably effected in an inert solvent such as benzine or petroleum ether, with the aid of formic acid or zinc chloride as condensing agent. Examples describe its condensation of (1) trimethylhydroquinone with phytyl bromide, 3-bromodihydrophytyl bromide and phytol, (2) 2 :5-dimethylhydroquinone with phytyl bromide, (3) 3 : 5-dimethylhydroquinone with phytyl bromide, phytol and 3-bromodihydrophytyl bromide, and (4) trimethylhydroquinone with isophytol. The formulae of some of the its products are given. Specification 508,292 is referred to. The Specification as open to inspection under Sect. 91 also describes the interaction of 2: 3-dimethylhydroquinone with phytyl bromide in the presence of zinc chloride, and refers to the use of phytol, isophytol and a phytyl dihalide for the same reaction. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH526884X | 1938-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB526884A true GB526884A (en) | 1940-09-27 |
Family
ID=4518242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8628/39A Expired GB526884A (en) | 1938-04-01 | 1939-03-17 | Improvements in or relating to the manufacture of d1-tocopherols |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB526884A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2486539A (en) * | 1946-07-19 | 1949-11-01 | Distillation Products Inc | Conversion of beta-, gamma-, and delta-tocopherol to alph-tocopherol |
| US2486541A (en) * | 1946-07-19 | 1949-11-01 | Distillation Products Inc | Delta-tocopherol |
| CN114989125A (en) * | 2022-05-30 | 2022-09-02 | 万华化学(四川)有限公司 | Preparation method of low-color-number vitamin E acetate |
-
1939
- 1939-03-17 GB GB8628/39A patent/GB526884A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2486539A (en) * | 1946-07-19 | 1949-11-01 | Distillation Products Inc | Conversion of beta-, gamma-, and delta-tocopherol to alph-tocopherol |
| US2486541A (en) * | 1946-07-19 | 1949-11-01 | Distillation Products Inc | Delta-tocopherol |
| CN114989125A (en) * | 2022-05-30 | 2022-09-02 | 万华化学(四川)有限公司 | Preparation method of low-color-number vitamin E acetate |
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