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GB2357507A - Peptide fragments of cholera toxin B or enterotoxin B as vaccine adjuvants - Google Patents

Peptide fragments of cholera toxin B or enterotoxin B as vaccine adjuvants

Info

Publication number
GB2357507A
GB2357507A GB0107375A GB0107375A GB2357507A GB 2357507 A GB2357507 A GB 2357507A GB 0107375 A GB0107375 A GB 0107375A GB 0107375 A GB0107375 A GB 0107375A GB 2357507 A GB2357507 A GB 2357507A
Authority
GB
United Kingdom
Prior art keywords
enterotoxin
peptide fragments
cholera toxin
vaccine adjuvants
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0107375A
Other versions
GB0107375D0 (en
Inventor
Neil Andrew Williams
Timothy Raymond Hirst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bristol
Original Assignee
University of Bristol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Bristol filed Critical University of Bristol
Publication of GB0107375D0 publication Critical patent/GB0107375D0/en
Publication of GB2357507A publication Critical patent/GB2357507A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A substance is described. The substance comprises any one or more of an amino acid sequence comprising the sequence presented as SEQ ID No. 2, or a variant thereof, or a homologue thereof, or a fragment thereof, or a derivative thereof, or a mimetic thereof; which substance is capable of acting in a manner that is the same as or is similar to EtxB and/or CtxB; but wherein the substance does not exhibit GM-1 binding activity.
GB0107375A 1998-09-07 1999-09-07 Peptide fragments of cholera toxin B or enterotoxin B as vaccine adjuvants Withdrawn GB2357507A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9819484.8A GB9819484D0 (en) 1998-09-07 1998-09-07 Therapeutic agents
PCT/GB1999/002970 WO2000014114A1 (en) 1998-09-07 1999-09-07 Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants

Publications (2)

Publication Number Publication Date
GB0107375D0 GB0107375D0 (en) 2001-05-16
GB2357507A true GB2357507A (en) 2001-06-27

Family

ID=10838466

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9819484.8A Ceased GB9819484D0 (en) 1998-09-07 1998-09-07 Therapeutic agents
GB0107375A Withdrawn GB2357507A (en) 1998-09-07 1999-09-07 Peptide fragments of cholera toxin B or enterotoxin B as vaccine adjuvants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9819484.8A Ceased GB9819484D0 (en) 1998-09-07 1998-09-07 Therapeutic agents

Country Status (19)

Country Link
EP (1) EP1109828A1 (en)
JP (1) JP2002524469A (en)
KR (1) KR20010044842A (en)
CN (1) CN1317013A (en)
AU (1) AU772015B2 (en)
BR (1) BR9913501A (en)
CA (1) CA2338384A1 (en)
CZ (1) CZ2001839A3 (en)
EA (1) EA200100314A1 (en)
GB (2) GB9819484D0 (en)
HU (1) HUP0104090A2 (en)
IL (1) IL141695A0 (en)
IS (1) IS5829A (en)
MX (1) MXPA01002387A (en)
NO (1) NO20011075L (en)
NZ (1) NZ509631A (en)
PL (1) PL346549A1 (en)
WO (1) WO2000014114A1 (en)
ZA (1) ZA200100758B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010036917A1 (en) 1995-07-05 2001-11-01 Williams Neil Andrew Therapeutic agents
GB9800487D0 (en) * 1998-01-09 1998-03-04 Oratol Limited Therapies
GB0115382D0 (en) * 2001-06-22 2001-08-15 Univ Bristol Mutant
MXPA05005528A (en) 2002-11-26 2006-04-05 Alk Abello As Pharmaceutical allergen product.
CN104402974B (en) * 2014-12-10 2017-11-14 重庆医科大学 A kind of polypeptide with mucosal adjuvant activity and its purposes in mucosal adjuvant is prepared
WO2024121125A1 (en) * 2022-12-06 2024-06-13 Bactolife A/S Single-domain antibodies to reduce the risk of cholera infection

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095426A1 (en) * 1982-05-26 1983-11-30 CNRS, Centre National de la Recherche Scientifique Synthetic polypeptides containing at least one sequence of the choleric B1 sub-unit toxin, and medicines containing them
DE3430894A1 (en) * 1983-08-23 1985-03-14 Yeda Research And Development Co., Ltd., Rehovot VACCINE AGAINST CHOLERA AND AGAINST HEAT LABILES E. COLI-TOXIN
WO1985002611A1 (en) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods therewith
WO1990003437A1 (en) * 1988-09-27 1990-04-05 L'universite De L'etat A Liege Proteins for fusing the sub-unit b of the choleraic toxin and heterologous antigen, and nucleic acids encoding them
WO1995020657A1 (en) * 1994-01-27 1995-08-03 Gx Biosystems A/S Receptor specific bacterial adhesins and their use
WO1995029701A1 (en) * 1994-05-03 1995-11-09 Yeda Research And Development Co., Ltd. Vaccines for oral immunization against infecting agents
WO1996006627A1 (en) * 1994-08-26 1996-03-07 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095426A1 (en) * 1982-05-26 1983-11-30 CNRS, Centre National de la Recherche Scientifique Synthetic polypeptides containing at least one sequence of the choleric B1 sub-unit toxin, and medicines containing them
DE3430894A1 (en) * 1983-08-23 1985-03-14 Yeda Research And Development Co., Ltd., Rehovot VACCINE AGAINST CHOLERA AND AGAINST HEAT LABILES E. COLI-TOXIN
WO1985002611A1 (en) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods therewith
WO1990003437A1 (en) * 1988-09-27 1990-04-05 L'universite De L'etat A Liege Proteins for fusing the sub-unit b of the choleraic toxin and heterologous antigen, and nucleic acids encoding them
WO1995020657A1 (en) * 1994-01-27 1995-08-03 Gx Biosystems A/S Receptor specific bacterial adhesins and their use
WO1995029701A1 (en) * 1994-05-03 1995-11-09 Yeda Research And Development Co., Ltd. Vaccines for oral immunization against infecting agents
WO1996006627A1 (en) * 1994-08-26 1996-03-07 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant

Also Published As

Publication number Publication date
EA200100314A1 (en) 2001-10-22
MXPA01002387A (en) 2002-05-08
ZA200100758B (en) 2001-07-16
GB0107375D0 (en) 2001-05-16
JP2002524469A (en) 2002-08-06
AU5751699A (en) 2000-03-27
PL346549A1 (en) 2002-02-11
CA2338384A1 (en) 2000-03-16
NZ509631A (en) 2003-11-28
NO20011075D0 (en) 2001-03-02
GB9819484D0 (en) 1998-10-28
IL141695A0 (en) 2002-03-10
NO20011075L (en) 2001-05-07
CZ2001839A3 (en) 2001-08-15
KR20010044842A (en) 2001-06-05
WO2000014114A1 (en) 2000-03-16
CN1317013A (en) 2001-10-10
EP1109828A1 (en) 2001-06-27
BR9913501A (en) 2001-06-05
HUP0104090A2 (en) 2002-01-28
IS5829A (en) 2001-03-07
AU772015B2 (en) 2004-04-08

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