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GB2067574B - Microbiologically prepared polypeptide with the amino acid sequence of proinsulin of a primate dna and plasmids which code for this sequence microorganisms which contain this genetic information and processes for their preparation - Google Patents

Microbiologically prepared polypeptide with the amino acid sequence of proinsulin of a primate dna and plasmids which code for this sequence microorganisms which contain this genetic information and processes for their preparation

Info

Publication number
GB2067574B
GB2067574B GB8101531A GB8101531A GB2067574B GB 2067574 B GB2067574 B GB 2067574B GB 8101531 A GB8101531 A GB 8101531A GB 8101531 A GB8101531 A GB 8101531A GB 2067574 B GB2067574 B GB 2067574B
Authority
GB
United Kingdom
Prior art keywords
sequence
microorganisms
proinsulin
preparation
genetic information
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8101531A
Other versions
GB2067574A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB2067574A publication Critical patent/GB2067574A/en
Application granted granted Critical
Publication of GB2067574B publication Critical patent/GB2067574B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The process for the preparation of the polypeptide which contains the amino-acid sequence of the proinsulin of primates entails the genetic information for the biosynthesis of the said polypeptide being obtained by means of mRNA from primates, the cDNA being prepared therefrom and inserted into a plasmid, the resulting hybrid plasmid being used to transform microorganisms, and the microorganisms producing the polypeptide being obtained by selection and cultivation.
GB8101531A 1980-01-19 1981-01-19 Microbiologically prepared polypeptide with the amino acid sequence of proinsulin of a primate dna and plasmids which code for this sequence microorganisms which contain this genetic information and processes for their preparation Expired GB2067574B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803001928 DE3001928A1 (en) 1980-01-19 1980-01-19 GENERAL PRODUCT OF A HIGHER ORGANISM FROM A MICROORGANISM CONTAINING THIS GENE

Publications (2)

Publication Number Publication Date
GB2067574A GB2067574A (en) 1981-07-30
GB2067574B true GB2067574B (en) 1983-10-19

Family

ID=6092503

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8101531A Expired GB2067574B (en) 1980-01-19 1981-01-19 Microbiologically prepared polypeptide with the amino acid sequence of proinsulin of a primate dna and plasmids which code for this sequence microorganisms which contain this genetic information and processes for their preparation

Country Status (14)

Country Link
EP (1) EP0032675B1 (en)
JP (1) JPS56104897A (en)
AT (1) ATE5151T1 (en)
AU (1) AU545665B2 (en)
BE (1) BE887129A (en)
CA (1) CA1192153A (en)
DE (2) DE3001928A1 (en)
ES (3) ES498451A0 (en)
FR (1) FR2479851A1 (en)
GB (1) GB2067574B (en)
IT (1) IT1136557B (en)
NL (1) NL8100210A (en)
SE (1) SE8100241L (en)
ZA (1) ZA81292B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7976518B2 (en) 2005-01-13 2011-07-12 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
US9028441B2 (en) 2011-09-08 2015-05-12 Corpak Medsystems, Inc. Apparatus and method used with guidance system for feeding and suctioning

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
EP0090433A1 (en) * 1982-03-31 1983-10-05 Genetics Institute, Inc. Creation of DNA sequences encoding modified proinsulin precursors
DE3380357D1 (en) * 1982-06-11 1989-09-14 Hoechst Ag Process for the preparation of obligate methylotrophic, foreign dna expressing bacteria, and appropriate plasmids and host organisms therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082613A (en) * 1976-04-23 1978-04-04 The Regents Of The University Of Minnesota Process for the production of insulin by genetically transformed fungal cells
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
NZ188837A (en) * 1977-11-08 1982-09-14 Genentech Inc Method for producing polypeptides using recombinant microbial cloning vehicles (eg plasmids) plasmids and transformed bacteria
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
GR71912B (en) * 1978-08-11 1983-08-16 Univ California
GR70279B (en) * 1979-09-12 1982-09-03 Univ California

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7976518B2 (en) 2005-01-13 2011-07-12 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
US9131956B2 (en) 2005-01-13 2015-09-15 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
US9579488B2 (en) 2005-01-13 2017-02-28 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
US9028441B2 (en) 2011-09-08 2015-05-12 Corpak Medsystems, Inc. Apparatus and method used with guidance system for feeding and suctioning

Also Published As

Publication number Publication date
ES499054A0 (en) 1982-06-01
ZA81292B (en) 1982-02-24
EP0032675B1 (en) 1983-10-26
CA1192153A (en) 1985-08-20
JPS56104897A (en) 1981-08-20
BE887129A (en) 1981-07-20
GB2067574A (en) 1981-07-30
IT1136557B (en) 1986-09-03
DE3161251D1 (en) 1984-01-19
ES499053A0 (en) 1982-02-16
ES8203101A1 (en) 1982-02-16
ATE5151T1 (en) 1983-11-15
ES8200722A1 (en) 1981-11-01
AU545665B2 (en) 1985-07-25
EP0032675A2 (en) 1981-07-29
ES498451A0 (en) 1981-11-01
JPS642584A (en) 1989-01-06
IT8119180A0 (en) 1981-01-16
EP0032675A3 (en) 1981-11-11
FR2479851A1 (en) 1981-10-09
NL8100210A (en) 1981-08-17
AU6628081A (en) 1981-07-30
SE8100241L (en) 1981-07-20
DE3001928A1 (en) 1981-08-06
ES8205427A1 (en) 1982-06-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee