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GB2055100A - Monacolin K derivatives - Google Patents

Monacolin K derivatives Download PDF

Info

Publication number
GB2055100A
GB2055100A GB8024665A GB8024665A GB2055100A GB 2055100 A GB2055100 A GB 2055100A GB 8024665 A GB8024665 A GB 8024665A GB 8024665 A GB8024665 A GB 8024665A GB 2055100 A GB2055100 A GB 2055100A
Authority
GB
United Kingdom
Prior art keywords
monacolin
sank
monascus
esters
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8024665A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9581479A external-priority patent/JPS5621594A/ja
Priority claimed from JP12346179A external-priority patent/JPS5646841A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of GB2055100A publication Critical patent/GB2055100A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB8024665A 1979-07-27 1980-07-28 Monacolin K derivatives Withdrawn GB2055100A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9581479A JPS5621594A (en) 1979-07-27 1979-07-27 Mb-530b carboxylic acid metal salt and its preparation
JP12346179A JPS5646841A (en) 1979-09-26 1979-09-26 Mb-530b carboxylic acid ester and its preparation

Publications (1)

Publication Number Publication Date
GB2055100A true GB2055100A (en) 1981-02-25

Family

ID=26436995

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8024665A Withdrawn GB2055100A (en) 1979-07-27 1980-07-28 Monacolin K derivatives

Country Status (16)

Country Link
AT (1) AT375334B (es)
AU (1) AU6083980A (es)
CH (1) CH647749A5 (es)
DD (1) DD153827A5 (es)
DE (1) DE3028284A1 (es)
DK (1) DK322380A (es)
ES (1) ES8105781A1 (es)
FI (1) FI71300C (es)
FR (1) FR2462417A1 (es)
GB (1) GB2055100A (es)
IT (1) IT1147763B (es)
NL (1) NL8004303A (es)
NO (1) NO156210C (es)
NZ (1) NZ194445A (es)
PL (1) PL225901A1 (es)
SE (1) SE445828B (es)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142146A2 (en) * 1983-11-14 1985-05-22 Merck & Co. Inc. Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0164049A2 (en) * 1984-06-04 1985-12-11 Merck & Co. Inc. Process for preparing HMG-CoA reductase inhibtors with a 3,5-dihydroxypentanoate subunit
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
EP0204287A2 (en) * 1985-06-04 1986-12-10 Merck & Co. Inc. Process for the preparation of HMG-CoA reductase inhibitors with a 3,5-Dihydroxypentanoate subunit
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
EP1089731A1 (en) * 1998-06-24 2001-04-11 Merck & Co., Inc. Compositions and methods for treating elevated blood cholesterol
WO2002020457A1 (en) * 2000-09-06 2002-03-14 Merck & Co., Inc. Dihydroxy open-acid salt of simvastatin
US6531507B1 (en) * 2000-06-09 2003-03-11 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US6541511B1 (en) 2001-06-12 2003-04-01 Ranbaxy Laboratories Limited Methyl analogs of simvastatin as novel HMG-CoA reductase inhibitors
US6583295B1 (en) 1998-09-18 2003-06-24 Lek Pharmaceuticals D.D. Salts of HMG-CoA reductase inhibitors
US6632428B1 (en) 1996-09-30 2003-10-14 Peking University Methods and compositions employing red rice fermentation products
US6806290B2 (en) 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US8715716B2 (en) 2002-03-07 2014-05-06 Jinis Biopharmaceuticals Co. Methods for producing low cholesterol animal products using hypocholesterolemic feed supplements and products therefrom

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101659923B (zh) * 2008-08-26 2011-10-26 北京北大维信生物科技有限公司 一种制备开环式洛伐他汀的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137322A (en) * 1976-11-02 1979-01-30 Sankyo Company Limited ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142146A3 (en) * 1983-11-14 1985-08-07 Merck & Co. Inc. Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0142146A2 (en) * 1983-11-14 1985-05-22 Merck & Co. Inc. Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0164049A2 (en) * 1984-06-04 1985-12-11 Merck & Co. Inc. Process for preparing HMG-CoA reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0164049A3 (en) * 1984-06-04 1987-05-27 Merck & Co. Inc. Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0204287A3 (en) * 1985-06-04 1987-07-01 Merck & Co. Inc. Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit
EP0204287A2 (en) * 1985-06-04 1986-12-10 Merck & Co. Inc. Process for the preparation of HMG-CoA reductase inhibitors with a 3,5-Dihydroxypentanoate subunit
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6632428B1 (en) 1996-09-30 2003-10-14 Peking University Methods and compositions employing red rice fermentation products
EP1089731A1 (en) * 1998-06-24 2001-04-11 Merck & Co., Inc. Compositions and methods for treating elevated blood cholesterol
EP1089731A4 (en) * 1998-06-24 2003-06-18 Merck & Co Inc COMPOSITIONS AND METHOD FOR TREATING INCREASED BLOOD CHOLESTEROL LEVELS
US6838566B2 (en) 1998-09-18 2005-01-04 Lek Pharmaceuticals D.D. Salts of HMG-CoA reductase inhibitors
US6583295B1 (en) 1998-09-18 2003-06-24 Lek Pharmaceuticals D.D. Salts of HMG-CoA reductase inhibitors
US6531507B1 (en) * 2000-06-09 2003-03-11 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US6806290B2 (en) 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
WO2002020457A1 (en) * 2000-09-06 2002-03-14 Merck & Co., Inc. Dihydroxy open-acid salt of simvastatin
US6541511B1 (en) 2001-06-12 2003-04-01 Ranbaxy Laboratories Limited Methyl analogs of simvastatin as novel HMG-CoA reductase inhibitors
US8715716B2 (en) 2002-03-07 2014-05-06 Jinis Biopharmaceuticals Co. Methods for producing low cholesterol animal products using hypocholesterolemic feed supplements and products therefrom
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype

Also Published As

Publication number Publication date
CH647749A5 (de) 1985-02-15
ATA392380A (de) 1983-12-15
DD153827A5 (de) 1982-02-03
IT8068211A0 (it) 1980-07-28
NO156210C (no) 1987-08-12
SE445828B (sv) 1986-07-21
FR2462417B1 (es) 1984-01-20
DK322380A (da) 1981-01-28
NO802244L (no) 1981-01-28
SE8005386L (sv) 1981-01-28
AU6083980A (en) 1981-01-29
FI802357A (fi) 1981-01-28
IT1147763B (it) 1986-11-26
PL225901A1 (es) 1982-07-19
NO156210B (no) 1987-05-04
AT375334B (de) 1984-07-25
ES493726A0 (es) 1981-06-16
ES8105781A1 (es) 1981-06-16
NZ194445A (en) 1984-07-06
DE3028284C2 (es) 1990-08-09
DE3028284A1 (de) 1981-02-19
NL8004303A (nl) 1981-01-29
FI71300C (fi) 1986-12-19
FI71300B (fi) 1986-09-09
FR2462417A1 (fr) 1981-02-13

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)