GB201200388D0 - Novel medical devices - Google Patents
Novel medical devicesInfo
- Publication number
- GB201200388D0 GB201200388D0 GBGB1200388.5A GB201200388A GB201200388D0 GB 201200388 D0 GB201200388 D0 GB 201200388D0 GB 201200388 A GB201200388 A GB 201200388A GB 201200388 D0 GB201200388 D0 GB 201200388D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- calixarene
- groups
- glycol
- derived
- medical devices
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VTJUKNSKBAOEHE-UHFFFAOYSA-N calixarene Chemical compound COC(=O)COC1=C(CC=2C(=C(CC=3C(=C(C4)C=C(C=3)C(C)(C)C)OCC(=O)OC)C=C(C=2)C(C)(C)C)OCC(=O)OC)C=C(C(C)(C)C)C=C1CC1=C(OCC(=O)OC)C4=CC(C(C)(C)C)=C1 VTJUKNSKBAOEHE-UHFFFAOYSA-N 0.000 abstract 7
- 125000003827 glycol group Chemical group 0.000 abstract 5
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 125000005647 linker group Chemical group 0.000 abstract 2
- 125000006850 spacer group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical group CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical group [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000004202 carbamide Chemical group 0.000 abstract 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical group ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000010452 phosphate Chemical group 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical group [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- -1 polytrimethylene Polymers 0.000 abstract 1
- 229910000077 silane Chemical group 0.000 abstract 1
- 150000003852 triazoles Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Paints Or Removers (AREA)
Abstract
Implantable medical devices, such as catheters, which comprise a calixarene-derived coating that resists adhesion and/or colonisation of bacteria, the calixarene being bonded to the surface of the device via one or more surface linker groups (preferably derived from acid chloride, chloroformate or silane functional groups) on the rim of the calixarene and comprising on the opposing rim one or more polyethylene glycol, polypropylene glycol or polytrimethylene glycol groups, or a mixture thereof; the glycol groups being attached to the calixarene via C3-16alkylene spacer groups; the glycol groups being either attached directly to the alkylene spacer group or via another linking group (such as a carbonate, carbamate, urea, phosphate or triazole group); said glycol groups having 2-250 repeating glycol units and being optionally terminated by hydrogen or C1â 4alkyl. The most preferred calixarene is of the form: The calixarene is preferably bonded to a device with a silicone surface. Calixarene-derived coating materials, intermediates useful in their manufacture, and to processes for the coating of the implantable devices are also claimed.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1200388.5A GB2498356B (en) | 2012-01-11 | 2012-01-11 | Calixarene-derived coatings for implantable medical devices |
| PCT/GB2013/050052 WO2013104916A2 (en) | 2012-01-11 | 2013-01-11 | Medical devices, coatings and compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1200388.5A GB2498356B (en) | 2012-01-11 | 2012-01-11 | Calixarene-derived coatings for implantable medical devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB201200388D0 true GB201200388D0 (en) | 2012-02-22 |
| GB2498356A GB2498356A (en) | 2013-07-17 |
| GB2498356B GB2498356B (en) | 2016-09-07 |
Family
ID=45788744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1200388.5A Active GB2498356B (en) | 2012-01-11 | 2012-01-11 | Calixarene-derived coatings for implantable medical devices |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2498356B (en) |
| WO (1) | WO2013104916A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140276356A1 (en) * | 2013-03-14 | 2014-09-18 | Teleflex Medical Incorporated | Novel Enhanced Device and Composition for Local Drug Delivery |
| EP3334706B1 (en) | 2015-08-10 | 2020-09-30 | Ramot at Tel-Aviv University Ltd. | Pillararenes and uses thereof |
| EP4308184A1 (en) * | 2021-03-15 | 2024-01-24 | ConvaTec Limited | Intermittent catheters |
| GB202103549D0 (en) | 2021-03-15 | 2021-04-28 | Convatec Ltd | Intermittent catheters |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4445998A (en) | 1981-12-02 | 1984-05-01 | Toyo Kohan Co., Ltd. | Method for producing a steel lithographic plate |
| US5053048A (en) | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
| DE19533310A1 (en) | 1995-07-24 | 1997-01-30 | Iro Ab | Thread delivery device |
| GB2312178A (en) | 1996-04-16 | 1997-10-22 | Univ Sheffield | New calixarenes and their use in waterproofing |
| US6602287B1 (en) | 1999-12-08 | 2003-08-05 | Advanced Cardiovascular Systems, Inc. | Stent with anti-thrombogenic coating |
| WO2002006407A2 (en) | 2000-07-17 | 2002-01-24 | President And Fellows Of Harvard College | Surfaces that resist the adsorption of biological species |
| US20040161443A1 (en) | 2001-04-17 | 2004-08-19 | Macneil Sheila | Vehicle |
| US7070798B1 (en) | 2002-06-21 | 2006-07-04 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine |
| GB2392163A (en) | 2002-08-20 | 2004-02-25 | Univ Sheffield | Soluble phenol-aldehyde condensate |
| US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| US20050221072A1 (en) | 2003-04-17 | 2005-10-06 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| EP1765429A2 (en) | 2004-05-12 | 2007-03-28 | Medtronic Vascular, Inc. | Drug-polymer coated stent |
| EA010940B1 (en) | 2004-11-05 | 2008-12-30 | Дау Корнинг Айэлэнд Лимитед | Plasma system |
| GB2448153B (en) * | 2007-04-04 | 2011-12-28 | Camstent Ltd Mbe | Coated medical devices |
| US20110130465A1 (en) * | 2009-12-01 | 2011-06-02 | Nerites Corporation | Coatings for prevention of biofilms |
-
2012
- 2012-01-11 GB GB1200388.5A patent/GB2498356B/en active Active
-
2013
- 2013-01-11 WO PCT/GB2013/050052 patent/WO2013104916A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| GB2498356B (en) | 2016-09-07 |
| GB2498356A (en) | 2013-07-17 |
| WO2013104916A3 (en) | 2013-10-17 |
| WO2013104916A2 (en) | 2013-07-18 |
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