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GB1512194A - Benzamides - Google Patents

Benzamides

Info

Publication number
GB1512194A
GB1512194A GB6215/77A GB621577A GB1512194A GB 1512194 A GB1512194 A GB 1512194A GB 6215/77 A GB6215/77 A GB 6215/77A GB 621577 A GB621577 A GB 621577A GB 1512194 A GB1512194 A GB 1512194A
Authority
GB
United Kingdom
Prior art keywords
benzamides
halogen
denotes
benzoylaziridines
haloethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6215/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1512194A publication Critical patent/GB1512194A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Benzamides of the formula <IMAGE> in which X denotes halogen, trifluoromethyl or C3-4-alkyl and Y denotes hydrogen, halogen or nitro, and N-oxides and acid addition salts thereof have useful MAO-inhibiting properties and are accordingly suitable in particular for the treatment of depressive states. These compounds are prepared by condensation of morpholine with appropriately substituted N-(2-haloethyl)benzamides or benzoylaziridines and optionally N-oxidation.
GB6215/77A 1976-02-16 1977-02-15 Benzamides Expired GB1512194A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT107076A AT345842B (en) 1976-02-16 1976-02-16 METHOD FOR PRODUCING NEW MORPHOLINE DERIVATIVES, THEIR N-OXYDES AND SALTS

Publications (1)

Publication Number Publication Date
GB1512194A true GB1512194A (en) 1978-05-24

Family

ID=3505951

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6215/77A Expired GB1512194A (en) 1976-02-16 1977-02-15 Benzamides

Country Status (28)

Country Link
JP (1) JPS52100476A (en)
AR (2) AR214307A1 (en)
AT (5) AT345842B (en)
AU (1) AU506427B2 (en)
BE (1) BE851422A (en)
CA (1) CA1076112A (en)
CH (5) CH623317A5 (en)
DE (1) DE2706179C2 (en)
DK (1) DK148824C (en)
ES (4) ES455907A1 (en)
FI (1) FI65426C (en)
FR (1) FR2340940A1 (en)
GB (1) GB1512194A (en)
GR (1) GR62413B (en)
HR (1) HRP930495B1 (en)
IE (1) IE44482B1 (en)
IL (1) IL51406A (en)
LU (2) LU76771A1 (en)
MC (1) MC1136A1 (en)
NL (2) NL179382C (en)
NO (2) NO148417C (en)
NZ (1) NZ183316A (en)
PH (1) PH12847A (en)
PT (1) PT66195B (en)
SE (1) SE426822B (en)
SI (1) SI7710060A8 (en)
YU (1) YU39983B (en)
ZA (1) ZA77746B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1716851A1 (en) * 2004-02-17 2006-11-02 Ishihara Sangyo Kaisha, Ltd. Thioamides and salts thereof and cytokine production inhibitors containing both
RU2570898C2 (en) * 2014-03-27 2015-12-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет имени Д.И. Менделеева (РХТУ им. Д.И. Менделеева)" Method for obtaining n-[2-(morpholin-4-yl)ethyl]-4-chlorobenzamide (versions)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1888535B1 (en) 2005-05-03 2008-11-19 Bayer CropScience S.A. New heterocyclylethylbenzamide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451142A (en) * 1965-01-19 1968-05-15 Sandoz Ag Process for the preparation of new basic substituted benzoic acid amides
FR1501846A (en) * 1966-09-26 1967-11-18 Bellon Labor Sa Roger Improved process for the preparation of thioamides
US3787419A (en) * 1971-07-01 1974-01-22 American Home Prod N-substituted-alpha,alpha,alpha-trifluoro-m-toluamides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1716851A1 (en) * 2004-02-17 2006-11-02 Ishihara Sangyo Kaisha, Ltd. Thioamides and salts thereof and cytokine production inhibitors containing both
EP1716851B1 (en) * 2004-02-17 2012-05-02 Ishihara Sangyo Kaisha, Ltd. Thioamides and salts thereof and cytokine production inhibitors containing both
RU2570898C2 (en) * 2014-03-27 2015-12-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет имени Д.И. Менделеева (РХТУ им. Д.И. Менделеева)" Method for obtaining n-[2-(morpholin-4-yl)ethyl]-4-chlorobenzamide (versions)

Also Published As

Publication number Publication date
AR214307A1 (en) 1979-05-31
NZ183316A (en) 1979-04-26
IL51406A (en) 1979-12-30
PT66195A (en) 1977-03-01
HRP930495B1 (en) 1996-10-31
DE2706179A1 (en) 1977-08-18
JPS52100476A (en) 1977-08-23
ATA107076A (en) 1978-02-15
CH623317A5 (en) 1981-05-29
NL7701144A (en) 1977-08-18
AT349480B (en) 1979-04-10
GR62413B (en) 1979-04-11
DE2706179C2 (en) 1984-02-02
ES467449A1 (en) 1978-10-16
NL930082I1 (en) 1993-09-16
SE426822B (en) 1983-02-14
AU506427B2 (en) 1980-01-03
AU2109977A (en) 1978-07-13
MC1136A1 (en) 1977-11-18
SE7701669L (en) 1977-08-17
FI770356A (en) 1977-08-17
CA1076112A (en) 1980-04-22
AT349482B (en) 1979-04-10
ATA25678A (en) 1978-09-15
LU88300I2 (en) 1994-09-09
YU39983B (en) 1985-06-30
NO148417B (en) 1983-06-27
LU76771A1 (en) 1978-04-13
CH622787A5 (en) 1981-04-30
FR2340940B1 (en) 1981-01-09
FI65426C (en) 1984-05-10
NL179382B (en) 1986-04-01
ES467448A1 (en) 1978-10-16
AT349479B (en) 1979-04-10
IL51406A0 (en) 1977-04-29
NL179382C (en) 1986-09-01
AR212554A1 (en) 1978-07-31
ZA77746B (en) 1977-12-28
JPS6215547B2 (en) 1987-04-08
AT345842B (en) 1978-10-10
AT349481B (en) 1979-04-10
ATA25878A (en) 1978-09-15
NO770488L (en) 1977-08-17
DK148824C (en) 1986-04-21
NO1994008I1 (en) 1994-08-03
FR2340940A1 (en) 1977-09-09
BE851422A (en) 1977-08-16
ATA25578A (en) 1978-09-15
YU6077A (en) 1983-01-21
DK51677A (en) 1977-08-17
ES455907A1 (en) 1978-05-01
PH12847A (en) 1979-09-12
DK148824B (en) 1985-10-14
PT66195B (en) 1979-01-17
CH623576A5 (en) 1981-06-15
IE44482L (en) 1977-08-16
FI65426B (en) 1984-01-31
ATA25778A (en) 1978-09-15
CH622786A5 (en) 1981-04-30
ES467455A1 (en) 1978-10-16
SI7710060A8 (en) 1996-12-31
NO148417C (en) 1983-10-12
NL930082I2 (en) 1994-08-16
IE44482B1 (en) 1981-12-16
CH623577A5 (en) 1981-06-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB93/082, 930621

CTFA Application for supplementary protection certificate granted

Free format text: SPC/GB93/082, 930928, EXPIRES:20020214

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB93/082, 970215, EXPIRES:20020214

PE20 Patent expired after termination of 20 years

Effective date: 19970214

SPCE Supplementary protection certificate expired

Free format text: SPC/GB93/082: 20020214