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ES467449A1 - Benzamides - Google Patents

Benzamides

Info

Publication number
ES467449A1
ES467449A1 ES467449A ES467449A ES467449A1 ES 467449 A1 ES467449 A1 ES 467449A1 ES 467449 A ES467449 A ES 467449A ES 467449 A ES467449 A ES 467449A ES 467449 A1 ES467449 A1 ES 467449A1
Authority
ES
Spain
Prior art keywords
benzamides
halogen
denotes
benzoylaziridines
haloethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467449A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES467449A1 publication Critical patent/ES467449A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Benzamides of the formula < IMAGE > in which X denotes halogen, trifluoromethyl or C3-4-alkyl and Y denotes hydrogen, halogen or nitro, and N-oxides and acid addition salts thereof have useful MAO-inhibiting properties and are accordingly suitable in particular for the treatment of depressive states. These compounds are prepared by condensation of morpholine with appropriately substituted N-(2-haloethyl)benzamides or benzoylaziridines and optionally N-oxidation.
ES467449A 1976-02-16 1978-03-01 Benzamides Expired ES467449A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT107076A AT345842B (en) 1976-02-16 1976-02-16 METHOD FOR PRODUCING NEW MORPHOLINE DERIVATIVES, THEIR N-OXYDES AND SALTS

Publications (1)

Publication Number Publication Date
ES467449A1 true ES467449A1 (en) 1978-10-16

Family

ID=3505951

Family Applications (4)

Application Number Title Priority Date Filing Date
ES455907A Expired ES455907A1 (en) 1976-02-16 1977-02-15 Benzamides
ES467449A Expired ES467449A1 (en) 1976-02-16 1978-03-01 Benzamides
ES467455A Expired ES467455A1 (en) 1976-02-16 1978-03-01 Benzamides
ES467448A Expired ES467448A1 (en) 1976-02-16 1978-03-01 Benzamides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES455907A Expired ES455907A1 (en) 1976-02-16 1977-02-15 Benzamides

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES467455A Expired ES467455A1 (en) 1976-02-16 1978-03-01 Benzamides
ES467448A Expired ES467448A1 (en) 1976-02-16 1978-03-01 Benzamides

Country Status (28)

Country Link
JP (1) JPS52100476A (en)
AR (2) AR214307A1 (en)
AT (5) AT345842B (en)
AU (1) AU506427B2 (en)
BE (1) BE851422A (en)
CA (1) CA1076112A (en)
CH (5) CH623317A5 (en)
DE (1) DE2706179C2 (en)
DK (1) DK148824C (en)
ES (4) ES455907A1 (en)
FI (1) FI65426C (en)
FR (1) FR2340940A1 (en)
GB (1) GB1512194A (en)
GR (1) GR62413B (en)
HR (1) HRP930495B1 (en)
IE (1) IE44482B1 (en)
IL (1) IL51406A (en)
LU (2) LU76771A1 (en)
MC (1) MC1136A1 (en)
NL (2) NL179382C (en)
NO (2) NO148417C (en)
NZ (1) NZ183316A (en)
PH (1) PH12847A (en)
PT (1) PT66195B (en)
SE (1) SE426822B (en)
SI (1) SI7710060A8 (en)
YU (1) YU39983B (en)
ZA (1) ZA77746B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4829506B2 (en) 2004-02-17 2011-12-07 石原産業株式会社 Thioamide compounds or salts thereof, and cytokine production inhibitors containing them
EP1888535B1 (en) 2005-05-03 2008-11-19 Bayer CropScience S.A. New heterocyclylethylbenzamide derivatives
RU2570898C2 (en) * 2014-03-27 2015-12-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет имени Д.И. Менделеева (РХТУ им. Д.И. Менделеева)" Method for obtaining n-[2-(morpholin-4-yl)ethyl]-4-chlorobenzamide (versions)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451142A (en) * 1965-01-19 1968-05-15 Sandoz Ag Process for the preparation of new basic substituted benzoic acid amides
FR1501846A (en) * 1966-09-26 1967-11-18 Bellon Labor Sa Roger Improved process for the preparation of thioamides
US3787419A (en) * 1971-07-01 1974-01-22 American Home Prod N-substituted-alpha,alpha,alpha-trifluoro-m-toluamides

Also Published As

Publication number Publication date
AR214307A1 (en) 1979-05-31
NZ183316A (en) 1979-04-26
GB1512194A (en) 1978-05-24
IL51406A (en) 1979-12-30
PT66195A (en) 1977-03-01
HRP930495B1 (en) 1996-10-31
DE2706179A1 (en) 1977-08-18
JPS52100476A (en) 1977-08-23
ATA107076A (en) 1978-02-15
CH623317A5 (en) 1981-05-29
NL7701144A (en) 1977-08-18
AT349480B (en) 1979-04-10
GR62413B (en) 1979-04-11
DE2706179C2 (en) 1984-02-02
NL930082I1 (en) 1993-09-16
SE426822B (en) 1983-02-14
AU506427B2 (en) 1980-01-03
AU2109977A (en) 1978-07-13
MC1136A1 (en) 1977-11-18
SE7701669L (en) 1977-08-17
FI770356A (en) 1977-08-17
CA1076112A (en) 1980-04-22
AT349482B (en) 1979-04-10
ATA25678A (en) 1978-09-15
LU88300I2 (en) 1994-09-09
YU39983B (en) 1985-06-30
NO148417B (en) 1983-06-27
LU76771A1 (en) 1978-04-13
CH622787A5 (en) 1981-04-30
FR2340940B1 (en) 1981-01-09
FI65426C (en) 1984-05-10
NL179382B (en) 1986-04-01
ES467448A1 (en) 1978-10-16
AT349479B (en) 1979-04-10
IL51406A0 (en) 1977-04-29
NL179382C (en) 1986-09-01
AR212554A1 (en) 1978-07-31
ZA77746B (en) 1977-12-28
JPS6215547B2 (en) 1987-04-08
AT345842B (en) 1978-10-10
AT349481B (en) 1979-04-10
ATA25878A (en) 1978-09-15
NO770488L (en) 1977-08-17
DK148824C (en) 1986-04-21
NO1994008I1 (en) 1994-08-03
FR2340940A1 (en) 1977-09-09
BE851422A (en) 1977-08-16
ATA25578A (en) 1978-09-15
YU6077A (en) 1983-01-21
DK51677A (en) 1977-08-17
ES455907A1 (en) 1978-05-01
PH12847A (en) 1979-09-12
DK148824B (en) 1985-10-14
PT66195B (en) 1979-01-17
CH623576A5 (en) 1981-06-15
IE44482L (en) 1977-08-16
FI65426B (en) 1984-01-31
ATA25778A (en) 1978-09-15
CH622786A5 (en) 1981-04-30
ES467455A1 (en) 1978-10-16
SI7710060A8 (en) 1996-12-31
NO148417C (en) 1983-10-12
NL930082I2 (en) 1994-08-16
IE44482B1 (en) 1981-12-16
CH623577A5 (en) 1981-06-15

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