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GB1504133A - 2-bromo-6beta-fluoro-pregnane compounds - Google Patents

2-bromo-6beta-fluoro-pregnane compounds

Info

Publication number
GB1504133A
GB1504133A GB4323177A GB4323177A GB1504133A GB 1504133 A GB1504133 A GB 1504133A GB 4323177 A GB4323177 A GB 4323177A GB 4323177 A GB4323177 A GB 4323177A GB 1504133 A GB1504133 A GB 1504133A
Authority
GB
United Kingdom
Prior art keywords
bromo
fluoro
6beta
steroids
pregnane compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4323177A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB4323177A priority Critical patent/GB1504133A/en
Publication of GB1504133A publication Critical patent/GB1504133A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1504133 2 - Bromo - 6# - fluoro - pregnane compounds G PALLADINO 24 Feb 1975 [8 March 1974] 43231/77 Divided out of 1504132 Heading C2U Novel steroids are 2 - bromo - 6# - fluoro 1,4,9(11),16 - pregnatetraene - 21 - ol - 3,20- dione 21 - acetate; 2 - bromo - 6# - fluoro - 1,4,9(11) - pregnatriene - 16α,17α,21 - triol - 3,20 - dione 21-acetate; and those of the formula wherein Ac is acetyl; Z is H or α- or #-CH 3 ; and R<SP>1</SP> is H or C 2-8 alkanoyl. They are prepared as illustrated in the following reaction schemes the second of which also illustrates their conversion to the steroids claimed in the parent Specification 1,504,132, and the first of which also illustrates the preparation of the steroids claimed in Specification 1,504,134.
GB4323177A 1975-02-24 1975-02-24 2-bromo-6beta-fluoro-pregnane compounds Expired GB1504133A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4323177A GB1504133A (en) 1975-02-24 1975-02-24 2-bromo-6beta-fluoro-pregnane compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4323177A GB1504133A (en) 1975-02-24 1975-02-24 2-bromo-6beta-fluoro-pregnane compounds

Publications (1)

Publication Number Publication Date
GB1504133A true GB1504133A (en) 1978-03-15

Family

ID=10427840

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4323177A Expired GB1504133A (en) 1975-02-24 1975-02-24 2-bromo-6beta-fluoro-pregnane compounds

Country Status (1)

Country Link
GB (1) GB1504133A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616742A (en) * 1994-06-01 1997-04-01 Schering Corporation Process for preparing Δ9,11 and 21-chloro corticosteroids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616742A (en) * 1994-06-01 1997-04-01 Schering Corporation Process for preparing Δ9,11 and 21-chloro corticosteroids

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Legal Events

Date Code Title Description
PS Patent sealed
48S Specification amended (sect. 8/1949)
SP Amendment (slips) printed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee