GB1492973A - Process for preparing injectable compositions - Google Patents
Process for preparing injectable compositionsInfo
- Publication number
- GB1492973A GB1492973A GB7156/74A GB715674A GB1492973A GB 1492973 A GB1492973 A GB 1492973A GB 7156/74 A GB7156/74 A GB 7156/74A GB 715674 A GB715674 A GB 715674A GB 1492973 A GB1492973 A GB 1492973A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allergen
- dialdehyde
- extract
- tyrosine
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000013566 allergen Substances 0.000 abstract 5
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 230000002009 allergenic effect Effects 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 239000000284 extract Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000428 dust Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 abstract 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 240000004658 Medicago sativa Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000000586 desensitisation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000009342 ragweed pollen Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000008223 sterile water Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
1492973 Modified allergens BEECHAM GROUP Ltd 5 Feb 1975 [16 Feb 1974] 7156/74 Addition to 1377074 Heading A5B Finely divided micro-particles of tyrosine having a water soluble dialdehyde - treated allergen dispersed therein are prepared by mixing an aqueous solution of a water - soluble dialdehyde e.g. glutaraldehyde modified allergenic extract of an allergenic material with a solution of tyrosine in a strong aqueous acid e.g. hydrochloric acid; and simultaneously or subsequently neutralising (i.e. adjusting the pH to from 4 to 7.5) such mixture of solutions thereby precipitating the required product. Sodium hydroxide may be employed to neutralise the reaction mixture. The aqueous solution of modified allergen may be obtained directly by reacting an aqueous solution of an extract of allergenic material with a dialdehyde under neutral conditions. The allergen may be an extract of one or more pollens e.g. grass or ragweed pollen; house dust, the house dust mite Dermatophagoides pteronyssinus, moulds, animal hair, dander or fur. The precipitate of tyrosine containing the dialdehyde treated allergen may be removed from the solution by centrifugation or filtration and washed before being resuspended in a physiologically acceptable carrier such as phenol-saline or sterile water, to produce an injectable composition for use in desensitisation therapy.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7156/74A GB1492973A (en) | 1974-02-16 | 1974-02-16 | Process for preparing injectable compositions |
| IE158/75A IE40370B1 (en) | 1974-02-16 | 1975-01-27 | Process for preparing injectable compositions |
| ZA00750634A ZA75634B (en) | 1974-02-16 | 1975-01-30 | Process for preparing injectionable compositions |
| AU77943/75A AU489860B2 (en) | 1974-02-16 | 1975-02-05 | Process for preparing injectionable compositions |
| FR7503870A FR2261013B2 (en) | 1974-02-16 | 1975-02-07 | |
| NLAANVRAGE7501582,A NL186295C (en) | 1974-02-16 | 1975-02-11 | PROCESS FOR PREPARING FINE DISTRIBUTED MICROPARTICLES OF TYROSINE, IN WHICH AN ALLERGEN IS DISPERSED. |
| DE2505814A DE2505814C2 (en) | 1974-02-16 | 1975-02-12 | Process for the production of finely divided microparticles of tyrosine with a content of a glutaraldehyde-modified allergen dispersed therein and an injectable solution containing these microparticles as an active ingredient |
| BE153404A BE825579R (en) | 1974-02-16 | 1975-02-14 | PROCESS FOR THE PREPARATION OF INJECTABLE COMPOSITIONS |
| JP50018110A JPS5822444B2 (en) | 1974-02-16 | 1975-02-14 | Allergen Oyuusurutyrosinno Seizouhou |
| US05/729,489 US4070455A (en) | 1974-02-16 | 1976-10-04 | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| KE3113A KE3113A (en) | 1974-02-16 | 1981-01-21 | Process for preparing injectable compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7156/74A GB1492973A (en) | 1974-02-16 | 1974-02-16 | Process for preparing injectable compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1492973A true GB1492973A (en) | 1977-11-23 |
Family
ID=9827690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7156/74A Expired GB1492973A (en) | 1974-02-16 | 1974-02-16 | Process for preparing injectable compositions |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5822444B2 (en) |
| BE (1) | BE825579R (en) |
| DE (1) | DE2505814C2 (en) |
| FR (1) | FR2261013B2 (en) |
| GB (1) | GB1492973A (en) |
| IE (1) | IE40370B1 (en) |
| KE (1) | KE3113A (en) |
| NL (1) | NL186295C (en) |
| ZA (1) | ZA75634B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044947A1 (en) * | 1997-04-05 | 1998-10-15 | Allergy Therapeutics Limited | Allergen formulation |
| EP0988862A3 (en) * | 1998-09-21 | 2001-06-20 | Allergy Therapeutics Limited | Formulation for use in immunisation |
| EP2042192A2 (en) | 1997-10-30 | 2009-04-01 | Laboratorios LETI, S.L. | Tolerogenic fragments of natural allergens |
| US8470331B2 (en) | 2000-01-14 | 2013-06-25 | Allergy Therapeutics (Uk) Limited | Composition of antigen and glycolipid adjuvant for sublingual administration |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234569A (en) * | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3541201A (en) * | 1968-12-18 | 1970-11-17 | Ethan Alan Brown | Novel sodium chloride encapsulated injectionable substances |
| BE754523A (en) * | 1969-08-06 | 1971-02-08 | Beecham Group Ltd | VACCINES |
| GB1377074A (en) * | 1971-07-13 | 1974-12-11 | Beecham Group Ltd | Process for preparing injectable compositions |
-
1974
- 1974-02-16 GB GB7156/74A patent/GB1492973A/en not_active Expired
-
1975
- 1975-01-27 IE IE158/75A patent/IE40370B1/en unknown
- 1975-01-30 ZA ZA00750634A patent/ZA75634B/en unknown
- 1975-02-07 FR FR7503870A patent/FR2261013B2/fr not_active Expired
- 1975-02-11 NL NLAANVRAGE7501582,A patent/NL186295C/en not_active IP Right Cessation
- 1975-02-12 DE DE2505814A patent/DE2505814C2/en not_active Expired
- 1975-02-14 JP JP50018110A patent/JPS5822444B2/en not_active Expired
- 1975-02-14 BE BE153404A patent/BE825579R/en active
-
1981
- 1981-01-21 KE KE3113A patent/KE3113A/en unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044947A1 (en) * | 1997-04-05 | 1998-10-15 | Allergy Therapeutics Limited | Allergen formulation |
| AU729631B2 (en) * | 1997-04-05 | 2001-02-08 | Allergy Therapeutics Limited | Allergen formulation |
| US7718178B2 (en) | 1997-04-05 | 2010-05-18 | Allergy Therapeutics Limited | Allergen formulation |
| US8105605B2 (en) | 1997-04-05 | 2012-01-31 | Allergy Therapeutics (Uk) Ltd. | Allergen formulation |
| EP2042192A2 (en) | 1997-10-30 | 2009-04-01 | Laboratorios LETI, S.L. | Tolerogenic fragments of natural allergens |
| EP0988862A3 (en) * | 1998-09-21 | 2001-06-20 | Allergy Therapeutics Limited | Formulation for use in immunisation |
| US6440426B1 (en) | 1998-09-21 | 2002-08-27 | Allergy Therapeutics Limited | Antigen-containing formulation and methods of use thereof |
| US7815920B2 (en) | 1998-09-21 | 2010-10-19 | Allergy Therapeutics (UK) Ltd | Method of preparing an antigen-containing formulation |
| US8470331B2 (en) | 2000-01-14 | 2013-06-25 | Allergy Therapeutics (Uk) Limited | Composition of antigen and glycolipid adjuvant for sublingual administration |
Also Published As
| Publication number | Publication date |
|---|---|
| AU7794375A (en) | 1976-08-05 |
| JPS50116626A (en) | 1975-09-12 |
| IE40370L (en) | 1975-08-16 |
| NL7501582A (en) | 1975-08-19 |
| FR2261013A2 (en) | 1975-09-12 |
| JPS5822444B2 (en) | 1983-05-09 |
| KE3113A (en) | 1981-02-20 |
| ZA75634B (en) | 1976-01-28 |
| FR2261013B2 (en) | 1978-07-21 |
| BE825579R (en) | 1975-08-14 |
| DE2505814A1 (en) | 1975-09-18 |
| DE2505814C2 (en) | 1984-11-15 |
| NL186295B (en) | 1990-06-01 |
| IE40370B1 (en) | 1979-05-09 |
| NL186295C (en) | 1990-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed |