GB1475513A - Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them - Google Patents
Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing themInfo
- Publication number
- GB1475513A GB1475513A GB2739274A GB2739274A GB1475513A GB 1475513 A GB1475513 A GB 1475513A GB 2739274 A GB2739274 A GB 2739274A GB 2739274 A GB2739274 A GB 2739274A GB 1475513 A GB1475513 A GB 1475513A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- benzylamine derivatives
- lower alkyl
- derivatives process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1475513 Oxazolines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 20 June 1975 [20 June 1974] 27392/74 Heading C2C Novel compounds of Formula I in which X is a hydrogen or halogen atom or a trifluoromethyl radical, R 1 is a lower alkyl radical or a lower cycloalkyl radical, R 2 is a hydrogen atom or a lower alkyl radical, and R 3 and R 4 , which may be the same or different, are hydrogen atoms or lower alkyl radicals or together form an alkylene group having from 3 to 6 carbon atoms where "lower" denotes group containing up to 6 carbon atoms on salts thereof are prepared by cyclization of a compound of Formula II #-Haloethyl urens of Formula II above are prepared by reacting a compound of Formula III with a compound of formula Starting materials of Formula III are obtained by reduction of an oxime formed from an R 1 COPh(X)CF 3 ketone or by reaction of cyanogen bromide with the alcohol obtained by reduction of such a ketone. Pharmaceutical compositions in conventional forms for buccil, rectal, sublingual or parenteral administration and having anti-hypertensive activity comprises an above novel compound and a carrier or diluent.
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2739274A GB1475513A (en) | 1974-06-20 | 1974-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
CA229,350A CA1062265A (en) | 1974-06-20 | 1975-06-13 | Process of preparation of new benzylamines |
DE19752526965 DE2526965A1 (en) | 1974-06-20 | 1975-06-16 | BENZYLAMINE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND |
IE1361/75A IE41382B1 (en) | 1974-06-20 | 1975-06-17 | Benzylamine derivatives process for their production and pharmaceutical compositions containing them |
FI751825A FI751825A (en) | 1974-06-20 | 1975-06-18 | |
DK274375AA DK136313B (en) | 1974-06-20 | 1975-06-18 | Analogous process for the preparation of N-substituted m-trifluoromethylbenzylamines. |
SE7507018A SE7507018L (en) | 1974-06-20 | 1975-06-18 | WAY TO PRODUCE NEW BENZYLAMINES. |
HU75SI1474A HU173390B (en) | 1974-06-20 | 1975-06-19 | Process for producing new benzylamine derivatives |
ZA00753943A ZA753943B (en) | 1974-06-20 | 1975-06-19 | Novel benzylamines, a process for making them and pharmaceutical compositions |
CH801275A CH597206A5 (en) | 1974-06-20 | 1975-06-19 | |
SU7502145925A SU578880A3 (en) | 1974-06-20 | 1975-06-19 | Method of preparing benzilaminooxazolines or their salts or their optical isomers |
AU82246/75A AU497501B2 (en) | 1974-06-20 | 1975-06-19 | Benzylamines |
AT471675A AT342046B (en) | 1974-06-20 | 1975-06-19 | METHOD FOR PRODUCING NEW N-BENZYLAMINOOXAZOLINES |
BE157510A BE830442A (en) | 1974-06-20 | 1975-06-19 | NEW BENZYLAMINES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING |
FR7519164A FR2275207A1 (en) | 1974-06-20 | 1975-06-19 | NEW BENZYLAMINES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING |
JP50074996A JPS5231341B2 (en) | 1974-06-20 | 1975-06-19 | |
ES438757A ES438757A1 (en) | 1974-06-20 | 1975-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
NL7507422A NL7507422A (en) | 1974-06-20 | 1975-06-20 | PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH BLOOD PRESSURE-LOWERING ACTION, SUCH MEDICINAL PRODUCT AND A PROCESS FOR PREPARING THE ACTIVE COMPOUNDS. |
DK141477A DK141477A (en) | 1974-06-20 | 1977-03-31 | M-TRIFLUOROMETHYLBENZYLAMINE COMPOUNDS FOR USE AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF N-SUBSTITUTED M-TRIFLUOROMETHYLBENZYLAMINES |
DK141377A DK138742B (en) | 1974-06-20 | 1977-03-31 | Process for the preparation of 2-aminooxazoline derivatives. |
AT402777A AT349464B (en) | 1974-06-20 | 1977-06-07 | PROCESS FOR THE PRODUCTION OF NEW N-BENZYLAMINO-OXAZOLINES |
SE7900681A SE7900681L (en) | 1974-06-20 | 1979-01-25 | SUBSTITUTED TRIFLUOROMETHYL BENZYLCARBAMIDES FOR USE AS INTERMEDIATE PRODUCTS FOR THE PREPARATION OF NITROGEN-SUBSTITUTED TRIFLUOROMETHYL BENZYLAMINES AND METHODS OF PREPARING URBAN |
CA332,309A CA1078869A (en) | 1974-06-20 | 1979-07-20 | Process for the preparation of novel benzylamines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2739274A GB1475513A (en) | 1974-06-20 | 1974-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1475513A true GB1475513A (en) | 1977-06-01 |
Family
ID=10258850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2739274A Expired GB1475513A (en) | 1974-06-20 | 1974-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5231341B2 (en) |
AT (1) | AT342046B (en) |
AU (1) | AU497501B2 (en) |
BE (1) | BE830442A (en) |
CA (1) | CA1062265A (en) |
CH (1) | CH597206A5 (en) |
DE (1) | DE2526965A1 (en) |
DK (1) | DK136313B (en) |
ES (1) | ES438757A1 (en) |
FI (1) | FI751825A (en) |
FR (1) | FR2275207A1 (en) |
GB (1) | GB1475513A (en) |
HU (1) | HU173390B (en) |
IE (1) | IE41382B1 (en) |
NL (1) | NL7507422A (en) |
SE (2) | SE7507018L (en) |
SU (1) | SU578880A3 (en) |
ZA (1) | ZA753943B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2951247A1 (en) * | 1978-12-20 | 1980-07-03 | Science Union & Cie | N-SUBSTITUTED TRIFLUORAETHYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2358890A1 (en) * | 1976-05-24 | 1978-02-17 | Science Union & Cie | NEW ARYL TRIFLUOROETHYLAMINES, THEIR METHODS OF OBTAINING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING |
JPS53105752U (en) * | 1977-01-31 | 1978-08-25 | ||
JPS5495252A (en) * | 1978-01-11 | 1979-07-27 | Oki Electric Ind Co Ltd | Thermal printer |
JPS57136755U (en) * | 1981-02-20 | 1982-08-26 | ||
AUPP020297A0 (en) * | 1997-11-05 | 1997-11-27 | University Of Melbourne, The | A novel receptor, and compounds which bind thereto |
-
1974
- 1974-06-20 GB GB2739274A patent/GB1475513A/en not_active Expired
-
1975
- 1975-06-13 CA CA229,350A patent/CA1062265A/en not_active Expired
- 1975-06-16 DE DE19752526965 patent/DE2526965A1/en active Pending
- 1975-06-17 IE IE1361/75A patent/IE41382B1/en unknown
- 1975-06-18 DK DK274375AA patent/DK136313B/en unknown
- 1975-06-18 FI FI751825A patent/FI751825A/fi not_active Application Discontinuation
- 1975-06-18 SE SE7507018A patent/SE7507018L/en unknown
- 1975-06-19 AT AT471675A patent/AT342046B/en not_active IP Right Cessation
- 1975-06-19 ZA ZA00753943A patent/ZA753943B/en unknown
- 1975-06-19 AU AU82246/75A patent/AU497501B2/en not_active Expired
- 1975-06-19 JP JP50074996A patent/JPS5231341B2/ja not_active Expired
- 1975-06-19 HU HU75SI1474A patent/HU173390B/en unknown
- 1975-06-19 FR FR7519164A patent/FR2275207A1/en active Granted
- 1975-06-19 CH CH801275A patent/CH597206A5/xx not_active IP Right Cessation
- 1975-06-19 BE BE157510A patent/BE830442A/en unknown
- 1975-06-19 SU SU7502145925A patent/SU578880A3/en active
- 1975-06-20 ES ES438757A patent/ES438757A1/en not_active Expired
- 1975-06-20 NL NL7507422A patent/NL7507422A/en not_active Application Discontinuation
-
1979
- 1979-01-25 SE SE7900681A patent/SE7900681L/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2951247A1 (en) * | 1978-12-20 | 1980-07-03 | Science Union & Cie | N-SUBSTITUTED TRIFLUORAETHYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
Also Published As
Publication number | Publication date |
---|---|
HU173390B (en) | 1979-04-28 |
BE830442A (en) | 1975-12-19 |
CA1062265A (en) | 1979-09-11 |
AU497501B2 (en) | 1978-12-14 |
CH597206A5 (en) | 1978-03-31 |
DE2526965A1 (en) | 1976-01-02 |
NL7507422A (en) | 1975-12-23 |
FI751825A (en) | 1975-12-21 |
DK274375A (en) | 1975-12-21 |
FR2275207A1 (en) | 1976-01-16 |
JPS5116662A (en) | 1976-02-10 |
AU8224675A (en) | 1976-12-23 |
ES438757A1 (en) | 1977-03-16 |
SE7900681L (en) | 1979-01-25 |
JPS5231341B2 (en) | 1977-08-13 |
SU578880A3 (en) | 1977-10-30 |
IE41382L (en) | 1975-12-20 |
IE41382B1 (en) | 1979-12-19 |
ZA753943B (en) | 1976-06-30 |
DK136313B (en) | 1977-09-26 |
AT342046B (en) | 1978-03-10 |
DK136313C (en) | 1978-02-20 |
ATA471675A (en) | 1977-07-15 |
FR2275207B1 (en) | 1979-08-10 |
SE7507018L (en) | 1975-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |