GB1435809A - 1h-tetrazole-1-acetate esters and acids and processes therefor - Google Patents
1h-tetrazole-1-acetate esters and acids and processes thereforInfo
- Publication number
- GB1435809A GB1435809A GB3813273A GB3813273A GB1435809A GB 1435809 A GB1435809 A GB 1435809A GB 3813273 A GB3813273 A GB 3813273A GB 3813273 A GB3813273 A GB 3813273A GB 1435809 A GB1435809 A GB 1435809A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkali metal
- radical
- acids
- hydrocarbon
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1435809 1 - H - Tetrazole - -1 - acetate esters and acids ELI LILLY & CO 13 Aug 1973 [14 Aug 1972] 38132/73 Heading C2C Novel tetrazolylacetate esters and acids having the general formula wherein R is a (C 1 -C 12 ) hydrocarbon radical free from aliphatic unsaturation, a (C 1 -C 12 ) hydrocarbon -O- radical free from aliphatic unsaturation or an -O- alkali metal radical; and R<SP>1</SP> is hydrogen, an alkali metal cation or a (C 1 -C 12 ) alkyl, (C 4 -C 8 ) cycloalkyl, phenyl, behzyl, p-nitrophenyl, p-nitrobenzyl, 2,2,2-trichloroethyl or phenacyl radical, as well those compounds of the above formula wherein R<SP>1</SP> may also be tolyl, xylyl or phenylethyl, are prepared by reacting an acyl cyanide of the formula (II) with an azidoacetic acid or ester thereof having the formula (III) at a temperature of from 80 to 135 C. The resultant tetrazolylacetate ester may be further reacted with either (a) an alcoholic alkali metal hydroxide to form the corresponding alkali metal salt, (b) a base to remove the 5-acyl substituent and form the alkali metal salt of 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon radical, or (c) with an acid to remove the 5-acyl substituent and form the 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon -O- radical.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28062572A | 1972-08-14 | 1972-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1435809A true GB1435809A (en) | 1976-05-19 |
Family
ID=23073908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3813273A Expired GB1435809A (en) | 1972-08-14 | 1973-08-13 | 1h-tetrazole-1-acetate esters and acids and processes therefor |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5821628B2 (en) |
| KR (1) | KR780000071B1 (en) |
| AR (1) | AR195626A1 (en) |
| AT (1) | AT329555B (en) |
| AU (1) | AU476519B2 (en) |
| BE (1) | BE803520A (en) |
| BG (1) | BG21220A3 (en) |
| CA (1) | CA998397A (en) |
| CH (1) | CH588475A5 (en) |
| CS (1) | CS179425B2 (en) |
| DD (1) | DD110272A5 (en) |
| DE (1) | DE2340409A1 (en) |
| ES (1) | ES417837A1 (en) |
| FR (1) | FR2196336B1 (en) |
| GB (1) | GB1435809A (en) |
| HU (1) | HU166844B (en) |
| IE (1) | IE37949B1 (en) |
| IL (1) | IL42843A (en) |
| NL (1) | NL179380C (en) |
| PH (1) | PH10552A (en) |
| PL (1) | PL89385B1 (en) |
| RO (1) | RO73460A (en) |
| SE (1) | SE402913B (en) |
| SU (1) | SU576935A3 (en) |
| YU (1) | YU36513B (en) |
| ZA (1) | ZA735075B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114085193A (en) * | 2021-11-20 | 2022-02-25 | 九江中星医药化工有限公司 | Method for preparing 1H-tetrazoleacetic acid and derivatives thereof by aqueous phase method |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854015B2 (en) * | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Process for the preparation of! H-TetrazoI-1-acetic acids and certain esters thereof |
| KR101350123B1 (en) | 2009-03-11 | 2014-01-09 | 닛뽕소다 가부시키가이샤 | Process for preparation of 1-alkyl-5-benzoyl-1h-tetrazole derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (en) * |
-
1973
- 1973-07-25 ZA ZA00735075A patent/ZA735075B/en unknown
- 1973-07-25 IE IE1268/73A patent/IE37949B1/en unknown
- 1973-07-26 AU AU58575/73A patent/AU476519B2/en not_active Expired
- 1973-07-27 IL IL42843A patent/IL42843A/en unknown
- 1973-08-02 CA CA177,995A patent/CA998397A/en not_active Expired
- 1973-08-03 PH PH14880A patent/PH10552A/en unknown
- 1973-08-07 YU YU02148/73A patent/YU36513B/en unknown
- 1973-08-09 DE DE19732340409 patent/DE2340409A1/en active Granted
- 1973-08-10 BE BE1005292A patent/BE803520A/en unknown
- 1973-08-10 AT AT703773A patent/AT329555B/en not_active IP Right Cessation
- 1973-08-10 HU HUEI490A patent/HU166844B/hu unknown
- 1973-08-13 ES ES417837A patent/ES417837A1/en not_active Expired
- 1973-08-13 PL PL1973164647A patent/PL89385B1/pl unknown
- 1973-08-13 SE SE7311051A patent/SE402913B/en unknown
- 1973-08-13 GB GB3813273A patent/GB1435809A/en not_active Expired
- 1973-08-13 SU SU7301955734A patent/SU576935A3/en active
- 1973-08-13 KR KR7301319A patent/KR780000071B1/en not_active Expired
- 1973-08-14 CH CH1171373A patent/CH588475A5/xx not_active IP Right Cessation
- 1973-08-14 NL NLAANVRAGE7311222,A patent/NL179380C/en not_active IP Right Cessation
- 1973-08-14 RO RO7375793A patent/RO73460A/en unknown
- 1973-08-14 AR AR249586A patent/AR195626A1/en active
- 1973-08-14 FR FR7329649A patent/FR2196336B1/fr not_active Expired
- 1973-08-14 CS CS7300005736A patent/CS179425B2/en unknown
- 1973-08-14 JP JP48091225A patent/JPS5821628B2/en not_active Expired
- 1973-08-14 DD DD172890A patent/DD110272A5/xx unknown
- 1973-08-14 BG BG024317A patent/BG21220A3/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114085193A (en) * | 2021-11-20 | 2022-02-25 | 九江中星医药化工有限公司 | Method for preparing 1H-tetrazoleacetic acid and derivatives thereof by aqueous phase method |
Also Published As
| Publication number | Publication date |
|---|---|
| IL42843A (en) | 1976-12-31 |
| AR195626A1 (en) | 1973-10-23 |
| SU576935A3 (en) | 1977-10-15 |
| AT329555B (en) | 1976-05-25 |
| IE37949B1 (en) | 1977-11-23 |
| HU166844B (en) | 1975-06-28 |
| FR2196336B1 (en) | 1977-02-25 |
| FR2196336A1 (en) | 1974-03-15 |
| BE803520A (en) | 1974-02-11 |
| AU476519B2 (en) | 1976-09-23 |
| DE2340409C2 (en) | 1988-03-17 |
| DD110272A5 (en) | 1974-12-12 |
| NL7311222A (en) | 1974-02-18 |
| IL42843A0 (en) | 1976-01-30 |
| CH588475A5 (en) | 1977-06-15 |
| JPS4975580A (en) | 1974-07-20 |
| CA998397A (en) | 1976-10-12 |
| ZA735075B (en) | 1975-03-26 |
| ATA703773A (en) | 1975-08-15 |
| YU214873A (en) | 1982-02-25 |
| CS179425B2 (en) | 1977-10-31 |
| SE402913B (en) | 1978-07-24 |
| JPS5821628B2 (en) | 1983-05-02 |
| KR780000071B1 (en) | 1978-03-30 |
| AU5857573A (en) | 1975-01-30 |
| YU36513B (en) | 1984-02-29 |
| PL89385B1 (en) | 1976-11-30 |
| IE37949L (en) | 1974-02-14 |
| NL179380C (en) | 1986-09-01 |
| ES417837A1 (en) | 1976-02-16 |
| RO73460A (en) | 1982-09-09 |
| DE2340409A1 (en) | 1974-02-28 |
| NL179380B (en) | 1986-04-01 |
| PH10552A (en) | 1977-06-08 |
| BG21220A3 (en) | 1976-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |