GB1304064A - - Google Patents
Info
- Publication number
- GB1304064A GB1304064A GB2882870A GB2882870A GB1304064A GB 1304064 A GB1304064 A GB 1304064A GB 2882870 A GB2882870 A GB 2882870A GB 2882870 A GB2882870 A GB 2882870A GB 1304064 A GB1304064 A GB 1304064A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- group
- formula
- thiophosphamide
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical class C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229930013397 isoquinoline alkaloid Natural products 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960001196 thiotepa Drugs 0.000 abstract 1
- JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1304064 Thiophosphamide derivatives of isoquinoline alkaloids LVOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT 15 June 1970 [16 June 1969] 28828/70 Heading C2P Novel compounds of Formula I: where X is A-CH 2 -CH 2 - or the group and A is a group of Formula II: where R, R 1 and R 2 are hydrogen or methoxy, or R 1 and R 2 together or R and R 1 together form a -O-CH 2 -CH 2 -O- group, R 3 is hydrogen, hydroxy or methyl, R 4 and R 5 are hydrogen or a dihydro group and R 6 is hydrogen, or R 4 and R 5 together or R 5 and R 6 together form part of a fused substituted naphthalene ring, may be prepared by reacting thiophosphamide with an isoquinoline alkaloid of Formula III or with a mixture of these alkaloids in an organic solvent at the boiling-point thereof. The compounds of Formula I may be used as the active ingredients in medicinal preparations for treating malignant tumours.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1330542A SU368254A1 (en) | 1969-06-16 | 1969-06-16 | Method of producing compounds of thiophosphamide with alkaloids of a large cleaner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1304064A true GB1304064A (en) | 1973-01-24 |
Family
ID=20445753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2882870A Expired GB1304064A (en) | 1969-06-16 | 1970-06-15 |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE752064A (en) |
| CH (1) | CH553225A (en) |
| CS (1) | CS155618B1 (en) |
| FR (1) | FR2052972B1 (en) |
| GB (1) | GB1304064A (en) |
| PL (1) | PL81014B1 (en) |
| RO (1) | RO57382A (en) |
| SE (1) | SE367637B (en) |
| SU (1) | SU368254A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003041721A1 (en) * | 2001-11-15 | 2003-05-22 | Nowicky Wassili | Process for reacting alkaloids and use of the reaction products in the preparation of medicaments |
| US7795434B2 (en) | 2003-03-18 | 2010-09-14 | Wassyl Nowicky | Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in manufacture of medicaments |
-
1969
- 1969-06-16 SU SU1330542A patent/SU368254A1/en active
-
1970
- 1970-06-11 CH CH883470A patent/CH553225A/en unknown
- 1970-06-12 PL PL14127270A patent/PL81014B1/pl unknown
- 1970-06-15 GB GB2882870A patent/GB1304064A/en not_active Expired
- 1970-06-15 SE SE828570A patent/SE367637B/xx unknown
- 1970-06-16 BE BE752064D patent/BE752064A/en unknown
- 1970-06-16 CS CS420870A patent/CS155618B1/cs unknown
- 1970-06-16 FR FR7022029A patent/FR2052972B1/fr not_active Expired
- 1970-06-16 RO RO6364670A patent/RO57382A/ro unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003041721A1 (en) * | 2001-11-15 | 2003-05-22 | Nowicky Wassili | Process for reacting alkaloids and use of the reaction products in the preparation of medicaments |
| KR100849488B1 (en) | 2001-11-15 | 2008-07-31 | 바실 노비키 | Alkaloid Reaction Method and Use of Reaction Products in Pharmaceutical Production |
| CN100436462C (en) * | 2001-11-15 | 2008-11-26 | 挪威奇·华兹 | Reaction method of alkaloid, reaction product and application thereof |
| US7795434B2 (en) | 2003-03-18 | 2010-09-14 | Wassyl Nowicky | Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in manufacture of medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2028330A1 (en) | 1971-05-27 |
| PL81014B1 (en) | 1975-08-30 |
| FR2052972A1 (en) | 1971-04-16 |
| DE2028330B2 (en) | 1977-02-03 |
| CH553225A (en) | 1974-08-30 |
| BE752064A (en) | 1970-12-16 |
| FR2052972B1 (en) | 1973-08-10 |
| SE367637B (en) | 1974-06-04 |
| SU368254A1 (en) | 1973-01-26 |
| CS155618B1 (en) | 1974-05-30 |
| RO57382A (en) | 1975-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |