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GB1292075A - Novel anti-inflammatory substances and production thereof - Google Patents

Novel anti-inflammatory substances and production thereof

Info

Publication number
GB1292075A
GB1292075A GB2194870A GB2194870A GB1292075A GB 1292075 A GB1292075 A GB 1292075A GB 2194870 A GB2194870 A GB 2194870A GB 2194870 A GB2194870 A GB 2194870A GB 1292075 A GB1292075 A GB 1292075A
Authority
GB
United Kingdom
Prior art keywords
filtrate
ethanol
inflammatory substance
fermentation broth
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2194870A
Inventor
Mamoru Sugiura
Kunio Kano
Kazuaki Kimura
Hiroyuki Oono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of GB1292075A publication Critical patent/GB1292075A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1292075 Anti-inflammatory substances ONO PHARMACEUTICAL CO Ltd 6 May 1970 [9 May 1969 26 Sept 1969] 21948/70 Heading A5B An anti-inflammatory substance obtained from a fermentation broth resulting from the cultivation of a microorganism of Aerobacter cloacae, Aerobacter aerogenes, Bacillus subtilis, Micrococus, lysodeikticus or Pseudomonas aeruginosa, and being odourless, tasteless, colourless, neutral with respect to pH, having a molecular weight higher than 200,000, soluble in water, insoluble in methanol, ethanol, acetone, benzene and ether, containing 5% ammonia nitrogen and 0.22% by weight phosphorus, giving positive m÷lisch, ninhydrin, biuret and chloroform-methanol extracted rhodamine stain reactions and negative xanthoproteic and direct rhodamine stain reactions, having an UV absorption spectrum showing absorption only at short waves and no maximum absorption at 280-260 mÁ and a specific rotation of [α]D<SP>26.5</SP> + 45‹ (c=1, water), may be prepared by cultivating a microorganism, as specified above, in a nutrient medium consisting of carbon and nitrogen sources and inorganic salts and recovering the anti-inflammatory substance from the resulting broth either (1) by precipitation from a filtrate of the fermentation broth by the addition of ethanol in the presence of potassium chloride or (2) by concentration of a filtrate of the fermentation broth, then dialysis in order to remove any low molecular weight substances and then subjection of the filtrate to gel-filtration in order to obtain a fraction containing the anti-inflammatory substance. In procedure (1), the potassium chloride may be added to the filtrate so that the concentration thereof is from 1 to 5% weight volume and then ethanol is added thereto in such an amount that the final alcohol concentration is from 40 to 80% weight/volume. The anti-inflammatory substance may be administered parenterally in the form of a saline solution.
GB2194870A 1969-05-09 1970-05-06 Novel anti-inflammatory substances and production thereof Expired GB1292075A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3587769 1969-05-09
JP7667369 1969-09-26

Publications (1)

Publication Number Publication Date
GB1292075A true GB1292075A (en) 1972-10-11

Family

ID=26374882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2194870A Expired GB1292075A (en) 1969-05-09 1970-05-06 Novel anti-inflammatory substances and production thereof

Country Status (8)

Country Link
BE (1) BE750148A (en)
CA (1) CA941770A (en)
CH (1) CH543586A (en)
DE (1) DE2022680A1 (en)
DK (1) DK128941B (en)
FR (1) FR2051510B1 (en)
GB (1) GB1292075A (en)
SE (1) SE378258B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315945A1 (en) * 1975-07-03 1977-01-28 Cassenne Lab Sa NEW GLYCOPROTEINS ISOLATED FROM AEROBACTER CLOACAE, PROCESS FOR THE PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS OF THESE PRODUCTS
CN109576189B (en) * 2018-12-29 2022-04-19 合肥市东方美捷分子材料技术有限公司 Composite microbial inoculum for black and odorous water body and preparation method and application thereof
CN115154487B (en) * 2022-08-24 2023-04-21 江西盐选科技有限公司 Polysaccharide salt fog mixture containing probiotics fermentation liquor and used for protecting respiratory tract and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE625519A (en) * 1962-11-30 1963-05-30 Kostocanellis Demetre Jean

Also Published As

Publication number Publication date
CA941770A (en) 1974-02-12
FR2051510B1 (en) 1974-03-22
CH543586A (en) 1973-10-31
SE378258B (en) 1975-08-25
FR2051510A1 (en) 1971-04-09
DK128941B (en) 1974-07-29
BE750148A (en) 1970-10-16
DE2022680A1 (en) 1970-11-19

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees