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GB1246127A - Bis-piperazinyl compounds - Google Patents

Bis-piperazinyl compounds

Info

Publication number
GB1246127A
GB1246127A GB39843/68A GB3984368A GB1246127A GB 1246127 A GB1246127 A GB 1246127A GB 39843/68 A GB39843/68 A GB 39843/68A GB 3984368 A GB3984368 A GB 3984368A GB 1246127 A GB1246127 A GB 1246127A
Authority
GB
United Kingdom
Prior art keywords
alkyl
piperazinyl
chy
bromophenyl
conh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39843/68A
Inventor
William James Ross
Stephen Slomo Szinai
Herschel Donovan Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Eli Lilly and Co
Original Assignee
Lilly Industries Ltd
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd, Eli Lilly and Co filed Critical Lilly Industries Ltd
Priority to GB39843/68A priority Critical patent/GB1246127A/en
Priority to NL6912496A priority patent/NL6912496A/xx
Priority to FR6928262A priority patent/FR2015967A1/fr
Priority to DE19691942135 priority patent/DE1942135A1/en
Priority to IL32861A priority patent/IL32861A0/en
Priority to CH1254669A priority patent/CH513882A/en
Priority to OA53713A priority patent/OA03432A/en
Priority to AT795369A priority patent/AT302304B/en
Priority to BE737646D priority patent/BE737646A/xx
Priority to BR211651/69A priority patent/BR6911651D0/en
Publication of GB1246127A publication Critical patent/GB1246127A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,246,127. Bis - piperazinyl compounds. LILLY INDUSTRIES Ltd., and ELI, LILLY & CO. 18 Aug., 1969 [20 Aug., 1968], No. 39843/68. Heading C2C. Novel compounds (I) (including salts thereof) where X is CO or SO 2 , R<SP>1</SP> is halogen, CF 3 , 5R<SP>5</SP> or OR<SP>5</SP> where R<SP>5</SP> is C 1-4 alkyl, R<SP>2</SP> is H, CO.R<SP>6</SP> where R<SP>6</SP> is alkyl, aryl, aralkyl, haloalkyl, CONH 2 , CONH.alkyl or CON(alkyl) 2 , R<SP>3</SP> is methylene optionally substituted by Me or Et, R<SP>4</SP> is H or C 1-6 alkyl and n is 0, 1 or 2, are obtained by interaction of R<SP>4</SP>.CHY.(R<SP>3</SP>) n .X. (R3) n .CHY.R<SP>4</SP> (Y is Cl, Br or I) and compound II (obtained, e.g. by treating a corresponding formyl derivative III with sodium borohydride) or by interaction of R<SP>4</SP>.CH=CR<SP>8</SP>.X.CR<SP>8</SP>= CH.R<SP>4</SP> (R<SP>8</SP> is H, Me or Et) and II (affords I in whicn n is 1); acylation and/or salt formation may be effected if desired. 2 - Bromo - 4 - (1 - piperazinyl) - benzaldehyde hydrochloride (i.e. a compound III) is obtained by treating the N-formyl derivative of N-(3- bromophenyl)-piperazine (formic acid on N-(3- bromophenyl)-piperazineobtained in turn, by reacting 3-bromoaniline with diethanolamine in the presence of HBr) with phosphorus oxychloride in the presence of dimethylformamide followed by hydrolysis. Pharmaceutical preparations having antischistosomiasis activity contain I as active ingredient; administration is orally or parenterally.
GB39843/68A 1968-08-20 1968-08-20 Bis-piperazinyl compounds Expired GB1246127A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB39843/68A GB1246127A (en) 1968-08-20 1968-08-20 Bis-piperazinyl compounds
NL6912496A NL6912496A (en) 1968-08-20 1969-08-15
FR6928262A FR2015967A1 (en) 1968-08-20 1969-08-18
DE19691942135 DE1942135A1 (en) 1968-08-20 1969-08-19 New chemical compounds
IL32861A IL32861A0 (en) 1968-08-20 1969-08-19 Piperazine derivatives having antischistosomiasis activity
CH1254669A CH513882A (en) 1968-08-20 1969-08-19 Process for the preparation of compounds having anti-schistosomiasis activity
OA53713A OA03432A (en) 1968-08-20 1969-08-19 Process for the preparation of bis-piperazino-sulfones and ketones.
AT795369A AT302304B (en) 1968-08-20 1969-08-19 Process for the production of new piperazine compounds and their salts
BE737646D BE737646A (en) 1968-08-20 1969-08-19
BR211651/69A BR6911651D0 (en) 1968-08-20 1969-08-19 COMPOUNDS HAVING ANTI-SHISTOSOMOSIS ACTIVITY AND PROCESS FOR ITS PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB39843/68A GB1246127A (en) 1968-08-20 1968-08-20 Bis-piperazinyl compounds

Publications (1)

Publication Number Publication Date
GB1246127A true GB1246127A (en) 1971-09-15

Family

ID=10411797

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39843/68A Expired GB1246127A (en) 1968-08-20 1968-08-20 Bis-piperazinyl compounds

Country Status (10)

Country Link
AT (1) AT302304B (en)
BE (1) BE737646A (en)
BR (1) BR6911651D0 (en)
CH (1) CH513882A (en)
DE (1) DE1942135A1 (en)
FR (1) FR2015967A1 (en)
GB (1) GB1246127A (en)
IL (1) IL32861A0 (en)
NL (1) NL6912496A (en)
OA (1) OA03432A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692448A (en) * 1984-11-20 1987-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Bis(arylpiperazinyl)sulfur compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610586B4 (en) * 1996-03-18 2006-04-27 Adc Gmbh Printed circuit board and accurate placement and soldering of electronic components on the surface of the circuit board
PT797379E (en) * 1996-03-18 2003-02-28 Krone Gmbh CIRCUIT BOARD PRINTED FOR PLACEMENT IN EXACT POSITION AND WELDING OF ELECTRONIC COMPONENTS ON THE SURFACE OF THE PRINTED CIRCUIT BOARD

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692448A (en) * 1984-11-20 1987-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Bis(arylpiperazinyl)sulfur compounds

Also Published As

Publication number Publication date
AT302304B (en) 1972-10-10
OA03432A (en) 1971-03-30
CH513882A (en) 1971-10-15
FR2015967A1 (en) 1970-04-30
DE1942135A1 (en) 1970-10-01
IL32861A0 (en) 1969-12-31
BE737646A (en) 1970-02-19
BR6911651D0 (en) 1973-02-08
NL6912496A (en) 1970-02-24

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