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GB1390867A - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
GB1390867A
GB1390867A GB323973A GB323973A GB1390867A GB 1390867 A GB1390867 A GB 1390867A GB 323973 A GB323973 A GB 323973A GB 323973 A GB323973 A GB 323973A GB 1390867 A GB1390867 A GB 1390867A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
compounds
quinoline derivatives
jan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB323973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of GB1390867A publication Critical patent/GB1390867A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

1390867 Quinoline derivatives SYNTHELABO 22 Jan 1973 [21 Jan 1972] 3239/73 Heading C2C The invention comprises quinoline derivatives of the Formula I and its acid addition salts, in which R represents C 1 to C 4 alkyl, hydroxy-alkyl, aryl, arylcarbonyl of formula or carbamoyl of formula where R 1 and R 2 represents C 1 to C 4 alkyl. The compounds of Formula I may be prepared by (i) reacting 4,7-dichloro-quinoline with a derivative of anthranilic acid of the formula or with 2 chloroethyl anthranilate, followed by condensation of the product with a piperazine of formula (ii) transesterifying the compounds of formulae where R 3 is alkyl or cycloalkyl. The compounds of Formula I are used as pharmaceuticals.
GB323973A 1972-01-21 1973-01-22 Quinoline derivatives Expired GB1390867A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7202035A FR2168227B1 (en) 1972-01-21 1972-01-21

Publications (1)

Publication Number Publication Date
GB1390867A true GB1390867A (en) 1975-04-16

Family

ID=9092249

Family Applications (1)

Application Number Title Priority Date Filing Date
GB323973A Expired GB1390867A (en) 1972-01-21 1973-01-22 Quinoline derivatives

Country Status (5)

Country Link
JP (1) JPS5026548B2 (en)
BE (1) BE794226A (en)
ES (1) ES410825A1 (en)
FR (1) FR2168227B1 (en)
GB (1) GB1390867A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642624B2 (en) 2001-01-12 2014-02-04 Amgen Inc. Substituted alkylamine derivatives and methods of use

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2280634A2 (en) * 1974-07-31 1976-02-27 Synthelabo 4-Phenyl-piperazino-alkyl anthranilate deriv prepn. - from 2-nitro-benzoic acid via acid halide or salts, condensation with phenyl-piperazino-alkyl radical and reduction
JPS54128241U (en) * 1978-02-28 1979-09-06
JPS6011483A (en) * 1983-06-29 1985-01-21 Taiho Yakuhin Kogyo Kk piperazine compounds
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US7307088B2 (en) * 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642624B2 (en) 2001-01-12 2014-02-04 Amgen Inc. Substituted alkylamine derivatives and methods of use

Also Published As

Publication number Publication date
DE2302708B2 (en) 1977-03-17
ES410825A1 (en) 1975-12-16
JPS4880574A (en) 1973-10-29
FR2168227B1 (en) 1975-03-14
DE2302708A1 (en) 1974-05-16
BE794226A (en) 1973-07-18
FR2168227A1 (en) 1973-08-31
JPS5026548B2 (en) 1975-09-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee