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GB1185065A - Diagnostic Reagent for Syphilis - Google Patents

Diagnostic Reagent for Syphilis

Info

Publication number
GB1185065A
GB1185065A GB40857/67A GB4085767A GB1185065A GB 1185065 A GB1185065 A GB 1185065A GB 40857/67 A GB40857/67 A GB 40857/67A GB 4085767 A GB4085767 A GB 4085767A GB 1185065 A GB1185065 A GB 1185065A
Authority
GB
United Kingdom
Prior art keywords
reiter
cardiolipin
protein
syphilis
latex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40857/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Publication of GB1185065A publication Critical patent/GB1185065A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1,185,065. Diagnosing syphilis. BAXTER LABORATORIES Inc. 7 Sept., 1967 [29 Sept., 1966], No. 40857/67. Heading B1X. A reagent for the diagnosis of syphilis comprises polystyrene latex particles having particle size from 0.1 to 0.35 microns and coated with cardiolipin and Reiter protein antigens. Preferred concentrations are 0.007 mg to 0.187 mg cardiolipin and 0.0005 mg to 0.03 mg Reiter protein per mg latex solids. The cardiolipin antigen is a composition comprising cardiolipin, cholesterol and lecithin. The Reiter protein is a standardized preparation obtained from Reiter treponemes. In an Example, the latex and the cardiolipin antigen are incubated in a glycine-saline-EDTA buffer at pH 8.2, the Reiter protein is added and the mixture is incubated again. The particles are centrifuged and resuspended in the above buffer plus choline chloride.
GB40857/67A 1966-09-29 1967-09-07 Diagnostic Reagent for Syphilis Expired GB1185065A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58306566A 1966-09-29 1966-09-29

Publications (1)

Publication Number Publication Date
GB1185065A true GB1185065A (en) 1970-03-18

Family

ID=24331552

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40857/67A Expired GB1185065A (en) 1966-09-29 1967-09-07 Diagnostic Reagent for Syphilis

Country Status (7)

Country Link
US (1) US3564089A (en)
BE (1) BE703073A (en)
DK (1) DK132636C (en)
ES (1) ES345586A1 (en)
FR (1) FR1605432A (en)
GB (1) GB1185065A (en)
IL (1) IL28638A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2344265A1 (en) * 1976-03-18 1977-10-14 Nippon Chemiphar Co IMPROVEMENTS TO ANTIGENIC MEMBRANES FOR THE DIAGNOSIS OF SYPHILIS AND APPARATUS USING SUCH A MEMBRANE
EP0038150A1 (en) * 1980-04-10 1981-10-21 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Sero-diagnostic method for syphilis and other diseases
US4588680A (en) * 1981-07-31 1986-05-13 Mount Sinai School Of Medicine Of The City University Of New York Assay for viruses

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184849A (en) * 1977-12-05 1980-01-22 Technicon Instruments Corporation Mixed agglutination
CA1146852A (en) * 1979-01-31 1983-05-24 Koichi Kondo Reagent for latex agglutination
US4696907A (en) * 1980-07-18 1987-09-29 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
JPS5871457A (en) * 1981-10-23 1983-04-28 Fujirebio Inc Manufacturing method for syphilis test reagent
US4605630A (en) * 1983-07-27 1986-08-12 Cooper Lipotech Inc. Large-liposome agglutination reagent and method
US4666831A (en) * 1985-02-19 1987-05-19 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4698299A (en) * 1985-02-19 1987-10-06 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4738932A (en) * 1985-12-03 1988-04-19 Advanced Polymer Systems, Inc. Reaginic test for syphilis
WO1991010138A1 (en) * 1989-12-27 1991-07-11 Baxter Diagnostics Inc. Method to immobilize cardiolipin, phosphatidyl choline and cholesterol to solid phase and immunoassay
DE10250368A1 (en) * 2002-10-29 2004-05-19 Viramed Biotech Ag Means and methods for diagnosing treponema infection
WO2006029081A2 (en) * 2004-09-02 2006-03-16 Neopharm, Inc. Nucleoside-lipid conjugates, their method of preparation and uses thereof
US8778619B2 (en) 2005-11-18 2014-07-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oxidized cardiolipin and uses to detect cardiolipin antibodies
WO2007061793A2 (en) 2005-11-18 2007-05-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SCIENCES, CENTERS FOR DISEASE CONTROL AND PREVENTION Modified cardiolipin and uses therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2344265A1 (en) * 1976-03-18 1977-10-14 Nippon Chemiphar Co IMPROVEMENTS TO ANTIGENIC MEMBRANES FOR THE DIAGNOSIS OF SYPHILIS AND APPARATUS USING SUCH A MEMBRANE
EP0038150A1 (en) * 1980-04-10 1981-10-21 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Sero-diagnostic method for syphilis and other diseases
US4588680A (en) * 1981-07-31 1986-05-13 Mount Sinai School Of Medicine Of The City University Of New York Assay for viruses

Also Published As

Publication number Publication date
BE703073A (en) 1968-01-15
US3564089A (en) 1971-02-16
FR1605432A (en) 1975-10-17
IL28638A (en) 1971-12-29
DK132636B (en) 1976-01-12
DK132636C (en) 1976-06-08
ES345586A1 (en) 1968-11-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee