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GB1294463A - Immunological reagent and process for making same - Google Patents

Immunological reagent and process for making same

Info

Publication number
GB1294463A
GB1294463A GB53071/69A GB5307169A GB1294463A GB 1294463 A GB1294463 A GB 1294463A GB 53071/69 A GB53071/69 A GB 53071/69A GB 5307169 A GB5307169 A GB 5307169A GB 1294463 A GB1294463 A GB 1294463A
Authority
GB
United Kingdom
Prior art keywords
reagent
indicator
antigen
immunological
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB53071/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB1294463A publication Critical patent/GB1294463A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/814—Pregnancy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y10S436/818—Human chorionic gonadotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1294463 Cellulose-antigen reaction products MILES LABORATORIES Inc 29 Oct 1969 [1 Nov 1968] 53071/69 Heading C3H [Also in Division B1] An immunological reagent comprises particles of a water-insoluble cellulose derivative having chemically linked thereto an antigen or antibody, itself having an acidic indicator material adsorbed on it. The cellulose derivative is preferably p-aminobenzyl or p-aminomethoxy benzyl cellulose and may be made reactive to immunological materials by diazotization. The indicator may be hematoxylin, fluorescein or titan yellow, and prior to its adsorption on to the antigen or antibody-treated particles any unreacted diazo groups on the particles may be treated with a dye-forming material, for example beta-naphthol. In use of the reagent, the immunological counterpart of the antigen or antibody in the reagent may become attached to the reagent particles, releasing the indicator into solution; alternatively the immunological counterpart may itself become attached to the indicator and the indicator colour remains with the particulate material. A spot of the reagent may be placed on a bibulous strip. The strip may then be "developed" with the sample under test or the sample may be placed on the reagent spot and the strip developed with saline. In the examples, the antigens or antibodies are human myoglobin, human haemoglobin, rabbit anti-HCG, HCG, rabbit anti-human haemoglobin, mule anti- HCG. Other antigens and antibodies are mentioned.
GB53071/69A 1968-11-01 1969-10-29 Immunological reagent and process for making same Expired GB1294463A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77285268A 1968-11-01 1968-11-01

Publications (1)

Publication Number Publication Date
GB1294463A true GB1294463A (en) 1972-10-25

Family

ID=25096449

Family Applications (1)

Application Number Title Priority Date Filing Date
GB53071/69A Expired GB1294463A (en) 1968-11-01 1969-10-29 Immunological reagent and process for making same

Country Status (4)

Country Link
US (1) US3641235A (en)
DE (1) DE1954974A1 (en)
FR (1) FR2022421A1 (en)
GB (1) GB1294463A (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966897A (en) * 1973-04-02 1976-06-29 Marine Colloids, Inc. Medium for use in bioassay and method of using same
US4166105A (en) * 1973-07-30 1979-08-28 Block Engineering, Inc. Dye tagged reagent
US4161515A (en) * 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
US4169137A (en) * 1974-12-20 1979-09-25 Block Engineering, Inc. Antigen detecting reagents
US4018884A (en) * 1975-06-26 1977-04-19 Hoffmann-La Roche Inc. Fluorogenic materials and labeling techniques
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
CA1095819A (en) * 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
IT1079045B (en) * 1977-05-16 1985-05-08 Syva Co DOUBLE RECEPTOR FLUORESCENT IMUUNOLOGICAL ANALYSIS
US4231750A (en) * 1977-12-13 1980-11-04 Diagnostic Reagents, Inc. Methods for performing chemical assays using fluorescence and photon counting
JPS54158995A (en) * 1978-06-06 1979-12-15 Green Cross Corp Hemoglobin measuring kit
US4302536A (en) * 1978-08-15 1981-11-24 Longenecker Robert W Colorimetric immunoassay process
JPS55124719A (en) * 1979-03-22 1980-09-26 Kowa Co Preparation of immune globulin administrable by intravenous injection
JPS5639022A (en) * 1979-09-05 1981-04-14 Hayashibara Biochem Lab Inc Preparation of vaccine
US4254096A (en) * 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
NL8000173A (en) * 1980-01-11 1981-08-03 Akzo Nv USE OF WATER-DISPERSIBLE HYDROPHOBIC DYES AS LABELS IN IMMUNOCHEMICAL TESTS.
FI61965C (en) * 1980-01-17 1982-10-11 Suovaniemi Finnpipette DETECTING OF HEMOGLOBIN AND DETECTION
US4668619A (en) * 1980-10-30 1987-05-26 Miles Laboratories, Inc. Multilayer homogeneous specific binding assay device
CA1183450A (en) * 1980-10-30 1985-03-05 Alfred C. Greenquist Homogeneous specific binding assay device and method
AU529210B3 (en) * 1983-02-02 1983-04-14 Australian Monoclonal Development Pty. Ltd. Monoclonal antibody in occult blood diagnosis
US4670381A (en) * 1985-07-19 1987-06-02 Eastman Kodak Company Heterogeneous immunoassay utilizing horizontal separation in an analytical element
US5053054A (en) * 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US20060040258A1 (en) * 2004-08-23 2006-02-23 Huiyan Guo Water-soluble conjugates and methods of preparation
CN100424500C (en) * 2004-08-27 2008-10-08 陈丽君 Cereal distilled liquor test agent
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
DE102009010563A1 (en) 2009-02-16 2010-08-26 Matthias W. Engel Device for the detection of analytes in body fluids
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
EP2976109B1 (en) 2013-03-21 2018-07-25 Genisphere, LLC Cellular delivery of dna intercalating agents
WO2015038978A1 (en) 2013-09-13 2015-03-19 Symbolics, Llc Lateral flow assays using two dimensional test and control signal readout patterns
CN107782891A (en) * 2017-10-19 2018-03-09 天津医科大学 A kind of construction method of multi-functional upper conversion nano platform

Also Published As

Publication number Publication date
FR2022421A1 (en) 1970-07-31
US3641235A (en) 1972-02-08
DE1954974A1 (en) 1970-05-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
CSNS Application of which complete specification have been accepted and published, but patent is not sealed