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GB1140387A - 4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines - Google Patents

4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines

Info

Publication number
GB1140387A
GB1140387A GB31938/66A GB3193866A GB1140387A GB 1140387 A GB1140387 A GB 1140387A GB 31938/66 A GB31938/66 A GB 31938/66A GB 3193866 A GB3193866 A GB 3193866A GB 1140387 A GB1140387 A GB 1140387A
Authority
GB
United Kingdom
Prior art keywords
alkenyl
aryl
alkyl
cycloalkyl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31938/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1140387A publication Critical patent/GB1140387A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02F—DREDGING; SOIL-SHIFTING
    • E02F9/00—Component parts of dredgers or soil-shifting machines, not restricted to one of the kinds covered by groups E02F3/00 - E02F7/00
    • E02F9/20—Drives; Control devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Mining & Mineral Resources (AREA)
  • Civil Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1,140,387. Tetrahydro - thiazolo - [5,4c]- pyridines. DR. KARL THOMAE, G.m.b.H. 15 July, 1966 [23 July, 1965], No. 31938/66. Heading C2C. [Also in Division A5] Novel compounds of the formula (wherein R 1 is H, C 1-6 alkyl, C 2-6 alkenyl, halo C 2-6 alkenyl, C 3-8 cycloalkyl, C 6-10 aryl, C 7-9 aralkyl, aromatic or aliphatic carboxylic or sulphonic acyl, carbamoyl or amidino; R 2 is H, C 1-6 alkyl, C 2-6 alkenyl, halo C 2-6 alkenyl, or cycloalkyl, or NR 1 R 2 is a heterocyclic ring which may contain a further hetero atom and/or be OH, methyl or phenyl substituted; R 3 is H, C 1-6 alkyl, C 2-6 alkenyl, halo C 2-6 alkenyl, C 3-8 cycloalkyl, C 6-10 aryl, C 7-9 aralkyl, aromatic or aliphatic carboxylic or sulphonic acyl, carbamoyl, thiocarbamoyl or amidino; and where alkyl groups R 1 , R 2 and/or R 3 may be OH, alkoxy, aryloxy, cycloalkyl, carboxy, carbalkoxy or amido substituted, and aromatic groups R 1 , R 2 and/or R 3 may be halogen, OH, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylenedioxy, amino, alkylamino, acylamino or aminosulphonyl substituted. R 4 and R 5 are H, alkyl, aryl or aralkyl; and R is a bond or a C 1-3 hydrocarbon chain) and acid-addition salts thereof, are prepared from hydrohalic acid salts of the appropriate 3-bromo-4-piperidones and thioureas or thioamides. Products wherein R 3 is aryl may be hydrolysed, provided R 1 is not aryl, to the corresponding compounds wherein R 3 is H, which compounds may in turn be reacted with appropriate reagents to replace the H atom R 3 by another radical or group R 3 (except aryl).
GB31938/66A 1965-07-23 1966-07-15 4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines Expired GB1140387A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DET0029055 1965-07-23
DET0032991 1967-01-16
DET0032993 1967-01-16
DET0032992 1967-01-16
DET0032990 1967-01-16
DET0032994 1967-01-16

Publications (1)

Publication Number Publication Date
GB1140387A true GB1140387A (en) 1969-01-15

Family

ID=27512321

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31938/66A Expired GB1140387A (en) 1965-07-23 1966-07-15 4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines

Country Status (7)

Country Link
BE (1) BE684415A (en)
BR (1) BR6681517D0 (en)
DE (1) DE1620508A1 (en)
ES (9) ES329299A1 (en)
FR (3) FR6013M (en)
GB (1) GB1140387A (en)
NL (2) NL6610324A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173187A (en) * 1985-03-23 1986-10-08 Erba Farmitalia Condensed 2-substituted thiazole derivatives
US4624956A (en) * 1983-12-16 1986-11-25 Farmitalia Carlo Erba Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives
US4847264A (en) * 1982-07-21 1989-07-11 Rorer Pharmaceutical Corporation Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
WO2004083218A1 (en) * 2003-03-20 2004-09-30 Actelion Pharmaceuticals Ltd Guanidine derivatives and use thereof as neuropeptide ff receptor antagonists
US7291734B2 (en) 2002-11-14 2007-11-06 Novartis Ag N-sulfonylaminothiazole
US7547786B2 (en) 2003-11-12 2009-06-16 Daiichi Sankyo Company, Limited Process for producing thiazole derivative
WO2010071822A1 (en) * 2008-12-19 2010-06-24 Schering Corporation Piperidine and piperazine derivatives and methods of use thereof
WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
US8541592B2 (en) 2005-11-22 2013-09-24 Amgen Inc. Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3680929D1 (en) 1985-02-06 1991-09-26 Boehringer Ingelheim Kg USE OF 2-AMINO-6-ALLYL-5,6,7,8-TETRAHYDRO-4H-THIAZOLO (4,5-D) AZEPINE FOR THE PRODUCTION OF A TREATMENT FOR PARKINSON'S DISEASE OR. MEDICINAL PRODUCT SUITABLE FOR PARKINSONISM.
US5060904A (en) * 1987-05-01 1991-10-29 David Hegarty Multi-positionable support stand with movable center of gravity and article holding means
DE69818094T2 (en) * 1997-12-11 2004-07-08 Biochem Pharma Inc., Laval ANTIVIRAL CONNECTIONS
SE0001899D0 (en) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
RS44304A (en) 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP6890179B2 (en) 2016-12-02 2021-06-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Bicyclic amide compounds and how to use them
UA125448C2 (en) 2017-07-14 2022-03-09 Ф. Хоффманн-Ля Рош Аг BICYCLIC KETONE COMPOUNDS AND METHODS OF THEIR APPLICATION
PE20211247A1 (en) * 2017-10-31 2021-07-13 Hoffmann La Roche SULFONES AND BICYCLE SULFOXIDES AND METHODS OF USING THEM
CN109134510A (en) * 2018-11-13 2019-01-04 井冈山大学 Prepare 2- amino -5-CBZ-4, the new method of 5,6,7- tetrahydro-thiazoles simultaneously [5,4-C] pyridine

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847264A (en) * 1982-07-21 1989-07-11 Rorer Pharmaceutical Corporation Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
US4624956A (en) * 1983-12-16 1986-11-25 Farmitalia Carlo Erba Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives
GB2173187A (en) * 1985-03-23 1986-10-08 Erba Farmitalia Condensed 2-substituted thiazole derivatives
US7291734B2 (en) 2002-11-14 2007-11-06 Novartis Ag N-sulfonylaminothiazole
US7727979B2 (en) 2003-03-20 2010-06-01 Actelion Pharmaceuticals Ltd. Guanidine derivatives and their use as neuropeptide FF receptor antagonists
WO2004083218A1 (en) * 2003-03-20 2004-09-30 Actelion Pharmaceuticals Ltd Guanidine derivatives and use thereof as neuropeptide ff receptor antagonists
JP2006520330A (en) * 2003-03-20 2006-09-07 アクテリオン　ファマシューティカルズ　リミテッド Guanidine derivatives and their use as neuropeptide FF receptor antagonists
US7547786B2 (en) 2003-11-12 2009-06-16 Daiichi Sankyo Company, Limited Process for producing thiazole derivative
US7678910B2 (en) 2003-11-12 2010-03-16 Daiichi Sankyo Company, Limited Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]Pyridine-2-carboxylic acid
US7880005B2 (en) 2003-11-12 2011-02-01 Daiichi Sankyo Company, Limited Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid
US8058440B2 (en) 2003-11-12 2011-11-15 Daiichi Sankyo Company, Limited Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid
US8541592B2 (en) 2005-11-22 2013-09-24 Amgen Inc. Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1
WO2010071822A1 (en) * 2008-12-19 2010-06-24 Schering Corporation Piperidine and piperazine derivatives and methods of use thereof
US20110245267A1 (en) * 2008-12-19 2011-10-06 Schering Plough Corporation Piperidine and piperazine derivatives and methods of use thereof
WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof

Also Published As

Publication number Publication date
ES349321A1 (en) 1969-04-01
ES349318A1 (en) 1969-04-01
BR6681517D0 (en) 1973-12-27
NL6610324A (en) 1967-01-24
ES329299A1 (en) 1968-02-16
ES349317A1 (en) 1969-04-01
NL6800589A (en) 1968-07-17
DE1620508A1 (en) 1969-09-18
FR1498465A (en) 1967-10-20
FR6013M (en) 1968-05-06
BE684415A (en) 1967-01-20
ES349319A1 (en) 1969-04-01
ES349314A1 (en) 1969-04-01
FR94123E (en) 1969-07-04
ES349316A1 (en) 1969-04-01
ES349322A1 (en) 1969-04-01
ES349320A1 (en) 1969-04-01

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