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GB1104292A - Pharmacologically active basic alcohols - Google Patents

Pharmacologically active basic alcohols

Info

Publication number
GB1104292A
GB1104292A GB27613/63A GB2761363A GB1104292A GB 1104292 A GB1104292 A GB 1104292A GB 27613/63 A GB27613/63 A GB 27613/63A GB 2761363 A GB2761363 A GB 2761363A GB 1104292 A GB1104292 A GB 1104292A
Authority
GB
United Kingdom
Prior art keywords
acid addition
addition salt
formula
compounds
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27613/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL130977D priority Critical patent/NL130977C/xx
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB27613/63A priority patent/GB1104292A/en
Priority to BE650330A priority patent/BE650330A/xx
Priority to FR981303A priority patent/FR1413914A/en
Priority to BR160763/64A priority patent/BR6460763D0/en
Priority to CH304467A priority patent/CH438369A/en
Priority to NL6407885A priority patent/NL6407885A/xx
Priority to ES0301905A priority patent/ES301905A1/en
Priority to CH906764A priority patent/CH449653A/en
Priority to DE19641518444 priority patent/DE1518444C/en
Priority to DK346664AA priority patent/DK111526B/en
Priority to SE8532/64A priority patent/SE318579B/xx
Priority to FR990979A priority patent/FR3741M/fr
Priority to DK341465AA priority patent/DK114842B/en
Publication of GB1104292A publication Critical patent/GB1104292A/en
Priority to SE03420/68A priority patent/SE328587B/xx
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the general formula <FORM:1104292/C2/1> (wherein A and A1 are alkyl groups each having 2 or 3 carbon atoms, R1 is a hydrogen atom, R is a methyl or ethyl group and A, A1 and R have between them from 5 to 7 carbon atoms, or A and A1 are alkyl groups each having 1 to 3 carbon atoms and R and R1 are each a methyl group) and their acid addition salts are prepared by (a) catalytically hydrogenating an acid addition salt of a secondary ketoamine of the formula <FORM:1104292/C2/2> optionally followed by conversion to the free base or another acid addition salt, or (b)-in the case of compounds in which R1 is a hydrogen atom-reacting a primary amine of the formula <FORM:1104292/C2/3> with CH3COR and catalytically hydrogenating the product, optionally followed by conversion to an acid addition salt. The starting materials for process (a) may be prepared by reacting a haloketone of the formula <FORM:1104292/C2/4> (wherein X is a halogen atom) with RR1CH3CNH2 in the presence of a solvent and converting the product to an acid addition salt. The preparation of p-dipropoxybenzene, 2,5-dipropoxypropiophenone, 2,5 - dipropoxyisonitrosopropiophenone and racemic erythro - a - (2,5 - dipropoxyphenyl) - b - aminopropanol and its hydrochloride is described. The compounds of the invention have anti-arrhythmic activity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB27613/63A 1963-07-11 1963-07-11 Pharmacologically active basic alcohols Expired GB1104292A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
NL130977D NL130977C (en) 1963-07-11
GB27613/63A GB1104292A (en) 1963-07-11 1963-07-11 Pharmacologically active basic alcohols
BE650330A BE650330A (en) 1963-07-11 1964-01-11
FR981303A FR1413914A (en) 1963-07-11 1964-07-09 New phenyl-aminopropanols and their preparation
BR160763/64A BR6460763D0 (en) 1963-07-11 1964-07-09 PROCESS TO PREPARE NEW COMPOUNDS OF ERYTHRO ALPHA 2,5-ALCOXYphenyl BETA ALKYLAMINE-PROPANOL
ES0301905A ES301905A1 (en) 1963-07-11 1964-07-10 Pharmacologically active basic alcohols
NL6407885A NL6407885A (en) 1963-07-11 1964-07-10
CH304467A CH438369A (en) 1963-07-11 1964-07-10 Process for the preparation of erythro-a-phenyl-B-aminopropanols
CH906764A CH449653A (en) 1963-07-11 1964-07-10 Process for the preparation of erythro-a-phenyl-B-aminopropanols
DE19641518444 DE1518444C (en) 1963-07-11 1964-07-10 erythro alpha phenyl beta amino propanols, processes for their preparation and medicaments containing such compounds
DK346664AA DK111526B (en) 1963-07-11 1964-07-10 Process for the preparation of erythro-α-phenyl-β-amino-propanols.
SE8532/64A SE318579B (en) 1963-07-11 1964-07-13
FR990979A FR3741M (en) 1963-07-11 1964-10-09
DK341465AA DK114842B (en) 1963-07-11 1965-07-03 Process for the preparation of erythro-α-phenyl-β-aminopropanols.
SE03420/68A SE328587B (en) 1963-07-11 1968-03-15

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB27613/63A GB1104292A (en) 1963-07-11 1963-07-11 Pharmacologically active basic alcohols

Publications (1)

Publication Number Publication Date
GB1104292A true GB1104292A (en) 1968-02-21

Family

ID=10262456

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27613/63A Expired GB1104292A (en) 1963-07-11 1963-07-11 Pharmacologically active basic alcohols

Country Status (9)

Country Link
BE (1) BE650330A (en)
BR (1) BR6460763D0 (en)
CH (2) CH449653A (en)
DK (2) DK111526B (en)
ES (1) ES301905A1 (en)
FR (2) FR1413914A (en)
GB (1) GB1104292A (en)
NL (2) NL6407885A (en)
SE (2) SE318579B (en)

Also Published As

Publication number Publication date
DE1518444A1 (en) 1969-08-07
FR1413914A (en) 1965-10-15
CH449653A (en) 1968-01-15
BR6460763D0 (en) 1973-09-20
NL130977C (en)
DK111526B (en) 1968-09-09
ES301905A1 (en) 1965-01-01
CH438369A (en) 1967-06-30
DK114842B (en) 1969-08-11
FR3741M (en) 1965-12-06
NL6407885A (en) 1965-01-12
BE650330A (en) 1964-01-11
SE328587B (en) 1970-09-21
SE318579B (en) 1969-12-15

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