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ES422738A1 - N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation - Google Patents

N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation

Info

Publication number
ES422738A1
ES422738A1 ES422738A ES422738A ES422738A1 ES 422738 A1 ES422738 A1 ES 422738A1 ES 422738 A ES422738 A ES 422738A ES 422738 A ES422738 A ES 422738A ES 422738 A1 ES422738 A1 ES 422738A1
Authority
ES
Spain
Prior art keywords
group
general formula
acylated
derivative
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES422738A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICHTHYOL GES CORDES HERMANNI U
Original Assignee
ICHTHYOL GES CORDES HERMANNI U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICHTHYOL GES CORDES HERMANNI U filed Critical ICHTHYOL GES CORDES HERMANNI U
Publication of ES422738A1 publication Critical patent/ES422738A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining heterocyclic compounds, based on N-acylated piperazine or homopipersizine of general formula (I) **(See formula)** wherein R1, R2 and/or R3 signify hydrogen atoms, lower or higher alkyl groups, halogen atoms and/or lower alkoxy groups, or R1 and R2 signify hydrogen atoms and R3 signifies an m-trifluoromethyl group, R4 is a valence bond, a methylene group, ethylidene or an ethylene group, n represents the number 1 or 2, R5 means a lower or higher alkyl group, an allyl or propargyl group, or a group of general formula (II) **(See formula)** where R6 and/or R7 signify hydrogen atoms, lower or higher alkyl or alkoxy groups and/or halogen atoms or R6 signifies a hydrogen atom and R7 can be an m-trifluoromethyl group and R8 signifies a hydrogen atom or a lower alkyl group, as well as its addition salts with quaternary ammonium acids and derivatives, pharmaceutically or therapeutically compatible, characterized in that a piperazine or homopiperazine derivative of general formula (III) **(See formula)** it is reacted with an acid derivative capable of N-acylation of the general formula (IV) **(See formula)** where R1, R2, R3, R4, R5 and n have the meaning defined above and R9 means a halogen atom or a lower alkoxy group, or a piperazine derivative or N-acylated homopiperazine of general formula (V) **(See formula)** N-acylated at the secondary nitrogen atom, with R1, R2, R3, R4 and n having the meaning defined above, either a piperazine derivative or N-acylated homopiperazine of general formula (V) is reacted with a halogenoacetyl derivative of general formula (VI) **(See formula)** where R6, R7 and R8 have the above defined meaning and R10 means a halogen atom. (Machine-translation by Google Translate, not legally binding)
ES422738A 1973-01-29 1974-01-29 N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation Expired ES422738A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2304155A DE2304155A1 (en) 1973-01-29 1973-01-29 N-ACYLATED SUBSTITUTED PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ES422738A1 true ES422738A1 (en) 1976-08-01

Family

ID=5870202

Family Applications (1)

Application Number Title Priority Date Filing Date
ES422738A Expired ES422738A1 (en) 1973-01-29 1974-01-29 N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation

Country Status (7)

Country Link
JP (1) JPS505389A (en)
BE (1) BE810293A (en)
DE (1) DE2304155A1 (en)
ES (1) ES422738A1 (en)
FR (1) FR2215236B1 (en)
GB (1) GB1434323A (en)
NL (1) NL7401215A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180574A (en) * 1978-12-26 1979-12-25 Abbott Laboratories Certain ovicidal piperazines
AU535498B2 (en) * 1981-05-08 1984-03-22 Otsuka Pharmaceutical Co., Ltd. Aniline derivatives, process for their preparation, and cardiotonics
JPS5879986A (en) * 1981-11-06 1983-05-13 Otsuka Pharmaceut Co Ltd Aniline derivative
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
AU2001238590A1 (en) * 2000-02-22 2001-09-03 Cv Therapeutics, Inc. Substituted piperazine compounds
AU2002344951A1 (en) * 2001-07-02 2003-01-21 Boehringer Ingelheim International Gmbh Substituted piperazine and diazepanes as histamine h3 receptor agonists
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
AU2005240991A1 (en) * 2004-04-15 2005-11-17 Georgetown University Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of Alzheimer's disease
JP2008007443A (en) * 2006-06-28 2008-01-17 Shiseido Co Ltd Cinnamic acid derivative, application of the same as ultraviolet ray absorber and ultraviolet ray absorbing composition formulated with the same, skin care preparation
WO2009031202A1 (en) * 2007-09-04 2009-03-12 Shiseido Company Ltd. Cinnamic acid derivatives and use thereof as ultraviolet absorber
AU2010291834A1 (en) * 2009-09-04 2012-03-15 Zalicus Pharmaceuticals Ltd. Substituted heterocyclic derivatives for the treatment of pain and epilepsy
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd Heterocyclic inhibitors of the sodium channel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE774447A (en) * 1970-11-11 1972-02-14 Biasedra Lab NEW DERIVATIVES OF SALICYLAMIDE AND THEIR APPLICATION IN THERAPEUTICS

Also Published As

Publication number Publication date
BE810293A (en) 1974-05-16
DE2304155A1 (en) 1974-08-01
JPS505389A (en) 1975-01-21
FR2215236A1 (en) 1974-08-23
FR2215236B1 (en) 1977-11-04
GB1434323A (en) 1976-05-05
NL7401215A (en) 1974-07-31

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