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GB1081667A - Method of preparing solid stable preparations of sensitive active substances - Google Patents

Method of preparing solid stable preparations of sensitive active substances

Info

Publication number
GB1081667A
GB1081667A GB17091/66A GB1709166A GB1081667A GB 1081667 A GB1081667 A GB 1081667A GB 17091/66 A GB17091/66 A GB 17091/66A GB 1709166 A GB1709166 A GB 1709166A GB 1081667 A GB1081667 A GB 1081667A
Authority
GB
United Kingdom
Prior art keywords
preparations
methyl
active substance
active substances
cellulose derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17091/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB1081667A publication Critical patent/GB1081667A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A solid, stable, pharmaceutical preparation is prepared by dissolving the active substance and a physiologically acceptable, water-dispersable cellulose derivative separately or together in an inert non-aqueous solvent (or, in the case of separate solutions, in two miscible non-aqueous solvents), combining the solutions if two are used, removing the solvent and drying the residue to give a fine dispersion of the active substance in the cellulose derivative. Suitable cellulose derivatives are methyl-, hydroxy-, propyl- and hydroxypropylmethylcellulose. Examples relate to preparations comprising Vitamins D2 and D3, Vitamin D3-cholesterol, 1a , 7a -diacetyl-thio-17a -methyl testo-sterone, ethinyl estradiol and chloramphenicol. Additives, e.g. antioxidants and fluidity and grinding improvers such as highly dispersed silicic acid, CaCO3, and calcium, aluminium and magnesium silicates may be included in the preparations, which may be tableted and made up into any conventional solid formulation.
GB17091/66A 1965-05-18 1966-04-09 Method of preparing solid stable preparations of sensitive active substances Expired GB1081667A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0065285 1965-05-18

Publications (1)

Publication Number Publication Date
GB1081667A true GB1081667A (en) 1967-08-31

Family

ID=7311393

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17091/66A Expired GB1081667A (en) 1965-05-18 1966-04-09 Method of preparing solid stable preparations of sensitive active substances

Country Status (10)

Country Link
BE (1) BE681216A (en)
BR (1) BR6679597D0 (en)
CH (1) CH483201A (en)
DE (1) DE1492034A1 (en)
DK (1) DK113235B (en)
ES (1) ES326829A1 (en)
FR (1) FR1522233A (en)
GB (1) GB1081667A (en)
IL (1) IL25710A (en)
NL (1) NL6605645A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218086A1 (en) * 1973-02-21 1974-09-13 Schering Ag
FR2218085A1 (en) * 1973-02-16 1974-09-13 Hoffmann La Roche
EP0002574A1 (en) * 1977-12-08 1979-06-27 Beecham Group Plc Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them
US4212863A (en) 1977-10-29 1980-07-15 Akzo N.V. Highly concentrated pharmaceutical formulations of steroids and processes for their preparation
US4406879A (en) 1979-11-07 1983-09-27 Nippon Kayaku Kabushiki Kaisha Phthalazinol preparation
EP0116755A1 (en) * 1983-02-22 1984-08-29 Teijin Limited Composition for solid pharmaceutical preparations of active vitamins D3 and process for preparation thereof
EP0240773A1 (en) * 1986-04-02 1987-10-14 Fujisawa Pharmaceutical Co., Ltd. Solid dispersion composition of FR-900506 substance
US5158944A (en) * 1989-03-01 1992-10-27 Teijin Limited Solid pharmaceutical preparations of active form of vitamin d3 of improved stability
WO2003092406A1 (en) * 2002-05-02 2003-11-13 Volker Kuellmer Coated, agglomerated phytochemicals
WO2007068287A1 (en) * 2005-12-15 2007-06-21 Laboratoria Qualiphar Sustained release vitamin preparation
US7368138B2 (en) 2002-03-21 2008-05-06 Archer-Daniels-Midland Company Extraction of phytosterols from corn fiber using green solvents
EP1997480A1 (en) * 2007-06-01 2008-12-03 The Jordanian Pharmaceutical Manufacturing Co. Mineral-fiber solid dispersion, method for preparing the same and use thereof as pharmaceutical tableting aid
US8563066B2 (en) 2007-12-17 2013-10-22 New World Pharmaceuticals, Llc Sustained release of nutrients in vivo

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791458A (en) * 1972-07-31 1973-05-16 Merck & Co Inc MICROENCAPSULE PRODUCT
DE2845326C2 (en) * 1978-10-18 1985-05-23 Beiersdorf Ag, 2000 Hamburg Use of a specific microdisperse, amorphous, porous silica for the production of digoxin-containing tablets with a strongly accelerated release of active ingredient
EP0315964B1 (en) * 1987-11-11 1993-01-07 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
FR2741533B1 (en) * 1995-11-28 1998-02-06 Grinda Jean Robert PROCESS FOR THE STABILIZATION OF POLYUNSATURATED FATTY ACIDS AND THE USE OF THESE STABILIZED PRODUCTS IN COSMETOLOGY
CA2713765A1 (en) * 2008-02-06 2009-08-13 Innov'ia Pulverulent composition and a process for preparing the same

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218085A1 (en) * 1973-02-16 1974-09-13 Hoffmann La Roche
FR2218086A1 (en) * 1973-02-21 1974-09-13 Schering Ag
US4212863A (en) 1977-10-29 1980-07-15 Akzo N.V. Highly concentrated pharmaceutical formulations of steroids and processes for their preparation
EP0002574A1 (en) * 1977-12-08 1979-06-27 Beecham Group Plc Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them
US4406879A (en) 1979-11-07 1983-09-27 Nippon Kayaku Kabushiki Kaisha Phthalazinol preparation
EP0116755A1 (en) * 1983-02-22 1984-08-29 Teijin Limited Composition for solid pharmaceutical preparations of active vitamins D3 and process for preparation thereof
US4729895A (en) * 1983-02-22 1988-03-08 Teijin Limited Composition for solid pharmaceutical preparations of active vitamins D.sub.3
EP0240773A1 (en) * 1986-04-02 1987-10-14 Fujisawa Pharmaceutical Co., Ltd. Solid dispersion composition of FR-900506 substance
US5158944A (en) * 1989-03-01 1992-10-27 Teijin Limited Solid pharmaceutical preparations of active form of vitamin d3 of improved stability
US7368138B2 (en) 2002-03-21 2008-05-06 Archer-Daniels-Midland Company Extraction of phytosterols from corn fiber using green solvents
US8114447B2 (en) 2002-03-21 2012-02-14 Archer Daniels Midland Company Extraction of phytosterols from corn fiber using green solvents
WO2003092406A1 (en) * 2002-05-02 2003-11-13 Volker Kuellmer Coated, agglomerated phytochemicals
WO2007068287A1 (en) * 2005-12-15 2007-06-21 Laboratoria Qualiphar Sustained release vitamin preparation
EP1997480A1 (en) * 2007-06-01 2008-12-03 The Jordanian Pharmaceutical Manufacturing Co. Mineral-fiber solid dispersion, method for preparing the same and use thereof as pharmaceutical tableting aid
WO2008145361A1 (en) * 2007-06-01 2008-12-04 The Jordanian Pharmaceutical Manufacturing Co. Mineral-fiber solid dispersion, method for preparing the same, and use thereof as pharmaceutical tableting aid
US8563066B2 (en) 2007-12-17 2013-10-22 New World Pharmaceuticals, Llc Sustained release of nutrients in vivo
US9538775B2 (en) 2007-12-17 2017-01-10 New World Pharmaceuticals, Llc Sustained release of nutrients in vivo
US9554586B2 (en) 2007-12-17 2017-01-31 New World Pharmaceuticals, Llc Sustained release of nutrients in vivo

Also Published As

Publication number Publication date
ES326829A1 (en) 1967-07-01
CH483201A (en) 1969-12-31
DK113235B (en) 1969-03-03
BE681216A (en) 1966-11-18
BR6679597D0 (en) 1973-10-23
DE1492034A1 (en) 1969-02-20
IL25710A (en) 1970-02-19
FR1522233A (en) 1968-04-26
NL6605645A (en) 1966-11-21

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