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GB1064539A - B/c trans-fused morphinan compounds and the preparation thereof - Google Patents

B/c trans-fused morphinan compounds and the preparation thereof

Info

Publication number
GB1064539A
GB1064539A GB4388565D GB4388565D GB1064539A GB 1064539 A GB1064539 A GB 1064539A GB 4388565 D GB4388565 D GB 4388565D GB 4388565 D GB4388565 D GB 4388565D GB 1064539 A GB1064539 A GB 1064539A
Authority
GB
United Kingdom
Prior art keywords
trans
fused
preparation
formula
morphinan compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4388565D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of GB1064539A publication Critical patent/GB1064539A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,064,539. Substituted morphinans. TANABE SEIYAKU CO. Ltd. Oct. 15, 1965 [Oct. 17, 1964; July 24, 1965], No. 43885/65. Heading C2C. Novel B/C trans-fused morphinan compounds of formula wherein R represents an alkyl group of 1-6 carbon atoms and X represents are prepared by reacting a compound of the formula wherein R is as defined above and Y represents with diborane and oxidizing the resulting 8- hydroborated derivative with hydrogen peroxide under alkaline conditions. Therapeutic compositions having analgesic activity, contain a compound of the first general formula above as the active ingredient.
GB4388565D 1964-10-17 1965-10-15 B/c trans-fused morphinan compounds and the preparation thereof Expired GB1064539A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5921964 1964-10-17
JP4498265 1965-07-24

Publications (1)

Publication Number Publication Date
GB1064539A true GB1064539A (en) 1967-04-05

Family

ID=26384941

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4388565D Expired GB1064539A (en) 1964-10-17 1965-10-15 B/c trans-fused morphinan compounds and the preparation thereof

Country Status (4)

Country Link
CH (1) CH449638A (en)
DE (1) DE1620513A1 (en)
FR (1) FR1503524A (en)
GB (1) GB1064539A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739145A (en) * 1993-06-30 1998-04-14 Toray Industries, Inc. Antitussive agents
US10391091B2 (en) 2014-11-19 2019-08-27 Siegfried Ag Method of manufacturing buprenorphine and analogues thereof from oripavine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739145A (en) * 1993-06-30 1998-04-14 Toray Industries, Inc. Antitussive agents
US10391091B2 (en) 2014-11-19 2019-08-27 Siegfried Ag Method of manufacturing buprenorphine and analogues thereof from oripavine

Also Published As

Publication number Publication date
FR1503524A (en) 1967-12-01
CH449638A (en) 1968-01-15
DE1620513A1 (en) 1970-04-09

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