GB1037640A - 6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidines - Google Patents
6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidinesInfo
- Publication number
- GB1037640A GB1037640A GB32308/64A GB3230864A GB1037640A GB 1037640 A GB1037640 A GB 1037640A GB 32308/64 A GB32308/64 A GB 32308/64A GB 3230864 A GB3230864 A GB 3230864A GB 1037640 A GB1037640 A GB 1037640A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- general formula
- alkyl group
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:1037640/C2/1> in which R1 is a straight or branched chain alkyl, alkenyl or aralkyl group, R2 is a hydrogen atom or an alkyl group, and R3 is a straight or branched chain alkyl group, an aryl group, an aralkyl group or an alkylthio group, or a group of the formula -NR4R5 in which R4 and R5 are hydrogen atoms or, together with the adjacent nitrogen atom, form a saturated heterocyclic group which may be interrupted by an oxygen atom, and their non-toxic salts with acids and bases, and the preparation thereof by reaction of a pyrrolidone ester formula <FORM:1037640/C2/2> (in which Alk is a lower alkyl group) with a compound of the general formula <FORM:1037640/C2/3> in the presence of a solvent, optionally using the acid addition salts of the last two compounds above in the presence of an acid binding agent, or reacting the alkali metal salt of the pyrrolidone ester of the above formula with the acid addition salt of the amidine of the above formula. The above process may be modified in that the pyrrolidone ester of the third general formula above is prepared by the Dieckmann condensation of a diester of the formula <FORM:1037640/C2/4> wherein n is 0 or 1 or m is 1 or 2 provided (m + n) is 2. Pharmaceutical compositions having antipyretic, antiphlogistic, analgesic, sedative, cardiovascular and/or cytostatic activity, in conventional form for oral, rectal, or parenteral administration, comprise a compound of the first general formula above or a salt thereof and a pharmaceutical carrier or excipient.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0024444 | 1963-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1037640A true GB1037640A (en) | 1966-08-03 |
Family
ID=7551453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32308/64A Expired GB1037640A (en) | 1963-08-07 | 1964-08-07 | 6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidines |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH431550A (en) |
| DE (1) | DE1470345A1 (en) |
| FR (1) | FR4087M (en) |
| GB (1) | GB1037640A (en) |
-
1963
- 1963-08-07 DE DE19631470345 patent/DE1470345A1/en active Pending
-
1964
- 1964-08-05 CH CH1024364A patent/CH431550A/en unknown
- 1964-08-07 GB GB32308/64A patent/GB1037640A/en not_active Expired
- 1964-11-03 FR FR993675A patent/FR4087M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH431550A (en) | 1967-03-15 |
| DE1470345A1 (en) | 1969-12-04 |
| FR4087M (en) | 1966-04-18 |
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