GB1005728A - New amino-guanidines and process for their manufacture - Google Patents
New amino-guanidines and process for their manufactureInfo
- Publication number
- GB1005728A GB1005728A GB4551161A GB4551161A GB1005728A GB 1005728 A GB1005728 A GB 1005728A GB 4551161 A GB4551161 A GB 4551161A GB 4551161 A GB4551161 A GB 4551161A GB 1005728 A GB1005728 A GB 1005728A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid addition
- addition salt
- methyl
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the general formulae <FORM:1005728/C2/1> and <FORM:1005728/C2/2> (wherein <FORM:1005728/C2/3> represents an unsubstituted or methyl-substituted 1, o -alkyleneimino ring containing 6 to 8 ring carbon atoms, A represents a 1,2-ethylene, 1,2-, 2,3- or 1,3-propylene radical, R1 represents a C1- 4 alkyl radical, and n and m each represents 1 or 2) and acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reacting a compound of the formula <FORM:1005728/C2/4> or <FORM:1005728/C2/5> or an acid addition salt thereof with S-methyl-2-isothiosemicarbazide or a salt thereof, or (b) reducing a compound of the formula <FORM:1005728/C2/6> or <FORM:1005728/C2/7> or an acid addition salt thereof, optionally followed in either case by conversion to the free base or an acid addition salt. 2 - (41 - Methylpiperazino)ethylamine is prepared from N-methylpiperazine, via 4-methylpiperazinoacetonitrile. The compounds of the invention are useful in the treatment of hypertensive conditions and functional peripheral vascular diseases, and may be administered enterally (e.g. orally) or parenterally in the form of pharmaceutical preparations (e.g. tablets, dragees, capsules, solutions, suspensions and emulsions) containing them, with or without other (unspecified) active ingredients, together with a carrier. Specifications 883,284 and 1,005,729 is referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7648060A | 1960-12-19 | 1960-12-19 | |
| US116246A US3189599A (en) | 1961-06-12 | 1961-06-12 | 1-[2-(n, n-alkylene-imino)-alkyl]-3-aminoguanidines and intermediates therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1005728A true GB1005728A (en) | 1965-09-29 |
Family
ID=26758156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB926865A Expired GB1005729A (en) | 1960-12-19 | 1961-12-17 | New nitro-guanidines and process for their manufacture |
| GB4551161A Expired GB1005728A (en) | 1960-12-19 | 1961-12-19 | New amino-guanidines and process for their manufacture |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB926865A Expired GB1005729A (en) | 1960-12-19 | 1961-12-17 | New nitro-guanidines and process for their manufacture |
Country Status (2)
| Country | Link |
|---|---|
| CH (2) | CH407129A (en) |
| GB (2) | GB1005729A (en) |
-
1961
- 1961-12-13 CH CH1446361A patent/CH407129A/en unknown
- 1961-12-13 CH CH586065A patent/CH408023A/en unknown
- 1961-12-17 GB GB926865A patent/GB1005729A/en not_active Expired
- 1961-12-19 GB GB4551161A patent/GB1005728A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH408023A (en) | 1966-02-28 |
| GB1005729A (en) | 1965-09-29 |
| CH407129A (en) | 1966-02-15 |
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