[go: up one dir, main page]

FR3095965B1 - Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues - Google Patents

Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues Download PDF

Info

Publication number
FR3095965B1
FR3095965B1 FR1905127A FR1905127A FR3095965B1 FR 3095965 B1 FR3095965 B1 FR 3095965B1 FR 1905127 A FR1905127 A FR 1905127A FR 1905127 A FR1905127 A FR 1905127A FR 3095965 B1 FR3095965 B1 FR 3095965B1
Authority
FR
France
Prior art keywords
microcapsules
polymer
active substance
surfactant
monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1905127A
Other languages
English (en)
Other versions
FR3095965A1 (fr
Inventor
Yves Ortais
Thierry Ribeiro
Kaouthar Oudoua
The Hien Ho
Didier Gigmes
Catherine Guillaneuf
Yohann Guillaneuf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gem'innov Fr
Original Assignee
GEM INNOV
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GEM INNOV, Aix Marseille Universite, Centre National de la Recherche Scientifique CNRS filed Critical GEM INNOV
Priority to FR1905127A priority Critical patent/FR3095965B1/fr
Priority to FR1912148A priority patent/FR3095966B1/fr
Priority to AU2020275917A priority patent/AU2020275917A1/en
Priority to CN202080036559.3A priority patent/CN113853250B/zh
Priority to EP20730315.7A priority patent/EP3969166A1/fr
Priority to BR112021022970-1A priority patent/BR112021022970B1/pt
Priority to JP2021568675A priority patent/JP2022532256A/ja
Priority to PCT/FR2020/000170 priority patent/WO2020229744A1/fr
Priority to US17/608,839 priority patent/US20230021302A9/en
Priority to US16/876,006 priority patent/US11654410B2/en
Publication of FR3095965A1 publication Critical patent/FR3095965A1/fr
Application granted granted Critical
Publication of FR3095965B1 publication Critical patent/FR3095965B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/18—In situ polymerisation with all reactants being present in the same phase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3719—Polyamides or polyimides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50—Perfumes
    • C11D3/502—Protected perfumes
    • C11D3/505—Protected perfumes encapsulated or adsorbed on a carrier, e.g. zeolite or clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Toxicology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Procédé de fabrication de microcapsules renfermant une substance dite active, procédé dans lequel : On approvisionne une solution aqueuse d’un tensioactif, une phase huileuse comprenant ladite substance active et au moins un premier monomère X, et une phase polaire comprenant au moins un deuxième monomère Y ; On prépare une émulsion de type O/W par ajout de ladite phase huileuse à ladite solution aqueuse du tensioactif ; On ajoute à ladite émulsion O/W ladite phase polaire, pour permettre l’obtention d’un polymère par polymérisation desdits monomères X et Y ; On isole à partir de ce mélange réactionnel lesdites microcapsules comportant une paroi formée par ledit polymère et renfermant ladite substance active ; ledit procédé étant caractérisé en ce que ledit polymère est un poly(beta-amino ester).
FR1905127A 2019-05-16 2019-05-16 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues Active FR3095965B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR1905127A FR3095965B1 (fr) 2019-05-16 2019-05-16 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
FR1912148A FR3095966B1 (fr) 2019-05-16 2019-10-29 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
CN202080036559.3A CN113853250B (zh) 2019-05-16 2020-05-14 可生物降解的微胶囊的制备方法和以该方式获得的微胶囊
EP20730315.7A EP3969166A1 (fr) 2019-05-16 2020-05-14 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
BR112021022970-1A BR112021022970B1 (pt) 2019-05-16 2020-05-14 Método para a preparação de microcápsulas biodegradáveis e microcápsulas obtidas desta maneira
JP2021568675A JP2022532256A (ja) 2019-05-16 2020-05-14 生分解性マイクロカプセルの調製方法及びこの方法で得たマイクロカプセル
AU2020275917A AU2020275917A1 (en) 2019-05-16 2020-05-14 Method for preparing biodegradable microcapsules and microcapsules obtained in this manner
PCT/FR2020/000170 WO2020229744A1 (fr) 2019-05-16 2020-05-14 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
US17/608,839 US20230021302A9 (en) 2019-05-16 2020-05-14 Method for preparing biodegradable microcapsules and microcapsules obtained in this manner
US16/876,006 US11654410B2 (en) 2019-05-16 2020-05-16 Method for preparing biodegradable microcapsules and microcapsules thus obtained

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1905127A FR3095965B1 (fr) 2019-05-16 2019-05-16 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
FR1905127 2019-05-16

Publications (2)

Publication Number Publication Date
FR3095965A1 FR3095965A1 (fr) 2020-11-20
FR3095965B1 true FR3095965B1 (fr) 2023-07-14

Family

ID=67999812

Family Applications (2)

Application Number Title Priority Date Filing Date
FR1905127A Active FR3095965B1 (fr) 2019-05-16 2019-05-16 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
FR1912148A Active FR3095966B1 (fr) 2019-05-16 2019-10-29 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR1912148A Active FR3095966B1 (fr) 2019-05-16 2019-10-29 Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues

Country Status (2)

Country Link
AU (1) AU2020275917A1 (fr)
FR (2) FR3095965B1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2318700A1 (fr) 1999-09-17 2001-03-17 Katsuyuki Fujita Pigments microencapsules thermochromiques
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
DE10139790A1 (de) 2001-08-14 2003-03-06 Henkel Kgaa Mikrokapseln, Verfahren zu deren Herstellung und deren Verwendung
US20070142263A1 (en) 2005-12-15 2007-06-21 Stahl Katherine D Color changing cleansing composition
EP2242774B2 (fr) 2008-02-15 2018-09-26 Catalyse Composition auto-reparante. materiaux a auto-reparation procedes d' autoreparation et applications
FR2986324A1 (fr) 2012-01-30 2013-08-02 Gem Innov Indicateur de respect d'une plage de temperature
CN105646911B (zh) * 2014-09-23 2019-07-09 中南大学 一种pH和还原响应性的肝靶向载药微球及其制备方法和用途
CN113244117B (zh) * 2014-12-16 2023-10-20 诺赛尔股份有限公司 提供活性物质的延迟释放的组合物

Also Published As

Publication number Publication date
FR3095966B1 (fr) 2023-07-14
FR3095965A1 (fr) 2020-11-20
FR3095966A1 (fr) 2020-11-20
AU2020275917A1 (en) 2021-12-09

Similar Documents

Publication Publication Date Title
Lorandi et al. Atom transfer radical polymerization: a mechanistic perspective
Zaquen et al. Visible light-mediated polymerization-induced self-assembly using continuous flow reactors
Keddie et al. Switchable reversible addition–fragmentation chain transfer (RAFT) polymerization in aqueous solution, N, N-dimethylacrylamide
Lv et al. Oxygen‐initiated and regulated controlled radical polymerization under ambient conditions
Sajjadi Nanoparticle formation by monomer-starved semibatch emulsion polymerization
CN105884640B (zh) 一种双阴离子界面引发剂及其制备方法
Baradie et al. Synthesis of fluorocarbon− vinyl acetate copolymers in supercritical carbon dioxide: insight into bulk properties
EP2822981B1 (fr) Procédé continu de synthèse de polymères greffés basé sur des polyéthers
CN105884987B (zh) 一种双磺酸盐界面引发剂及其制备方法
Li et al. A surfactant-free emulsion RAFT polymerization of methyl methacrylate in a continuous tubular reactor
CN105820273A (zh) 一种双子型阴离子表面活性引发剂及其制备方法
CN105884939B (zh) 一种双子型表面活性引发剂的使用方法
Songsing et al. Kinetics and mechanism of grafting styrene onto natural rubber in emulsion polymerization using cumene hydroperoxide–tetraethylenepentamine as redox initiator
EA201100876A1 (ru) Способ получения хаотических радикальных сополимеров и композиций активного вещества, получаемых из них
CN105820275A (zh) 一种双子型阳离子表面活性引发剂及其制备方法
CN105884940B (zh) 一种双苯磺酸盐界面引发剂及其制备方法
FR3095966B1 (fr) Procede de preparation de microcapsules biodegradables et microcapsules ainsi obtenues
FR3088067B1 (fr) Procede de synthese de polymeres par polymerisation radicalaire controlee en emulsion inverse
Nakamura et al. Modular synthesis of mid-chain-functionalized polymers by photoinduced diene-and styrene-assisted radical coupling reaction of polymer-end radicals
Jaramillo-Soto et al. RAFT copolymerization with crosslinking of methyl methacrylate and ethylene glycol dimethacrylate in supercritical carbon dioxide
Guice et al. Azeotropic atom transfer radical polymerization of hydroxyethyl methacrylate and (dimethylamino) ethyl methacrylate statistical copolymers and block copolymers with polystyrene
JP2012107163A (ja) ラジカル共重合体の製法およびそれに用いる連続式マイクロ反応装置
JP2008001771A (ja) カチオン重合による重合体の製造方法
KR100572013B1 (ko) 현탁중합으로 입도분포도가 균일한 비닐계 고분자 입자의제조방법
EP2749579B1 (fr) Polymère diénique conjugué et son procédé de préparation

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 2

PLSC Publication of the preliminary search report

Effective date: 20201120

PLFP Fee payment

Year of fee payment: 3

PLFP Fee payment

Year of fee payment: 4

TP Transmission of property

Owner name: GEM'INNOV, FR

Effective date: 20230315

PLFP Fee payment

Year of fee payment: 5

PLFP Fee payment

Year of fee payment: 6