FR3049867A1 - HEMOSTATIC AND HEALING COMPOSITION - Google Patents
HEMOSTATIC AND HEALING COMPOSITION Download PDFInfo
- Publication number
- FR3049867A1 FR3049867A1 FR1653186A FR1653186A FR3049867A1 FR 3049867 A1 FR3049867 A1 FR 3049867A1 FR 1653186 A FR1653186 A FR 1653186A FR 1653186 A FR1653186 A FR 1653186A FR 3049867 A1 FR3049867 A1 FR 3049867A1
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- FR
- France
- Prior art keywords
- water
- composition
- composition according
- soluble
- alginate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims abstract description 32
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 16
- 229920000615 alginic acid Polymers 0.000 claims abstract description 16
- 229940072056 alginate Drugs 0.000 claims abstract description 14
- 230000035876 healing Effects 0.000 claims abstract description 14
- 235000002961 Aloe barbadensis Nutrition 0.000 claims abstract description 12
- 244000186892 Aloe vera Species 0.000 claims abstract description 12
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 12
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 229920001577 copolymer Polymers 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 235000010413 sodium alginate Nutrition 0.000 claims description 4
- 239000000661 sodium alginate Substances 0.000 claims description 4
- 229940005550 sodium alginate Drugs 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- MXRGSJAOLKBZLU-UHFFFAOYSA-N 3-ethenylazepan-2-one Chemical compound C=CC1CCCCNC1=O MXRGSJAOLKBZLU-UHFFFAOYSA-N 0.000 claims description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
- 229910052744 lithium Inorganic materials 0.000 claims description 2
- 235000010408 potassium alginate Nutrition 0.000 claims description 2
- 239000000737 potassium alginate Substances 0.000 claims description 2
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 150000003926 acrylamides Chemical class 0.000 claims 1
- YTSACTNRGUJEGO-UHFFFAOYSA-N oxirane prop-1-ene Chemical group CC=C.C1CO1 YTSACTNRGUJEGO-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- 239000000499 gel Substances 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 229940030225 antihemorrhagics Drugs 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 230000000025 haemostatic effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
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- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
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- 239000008406 cosmetic ingredient Substances 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000006068 polycondensation reaction Methods 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- KSLINXQJWRKPET-UHFFFAOYSA-N 3-ethenyloxepan-2-one Chemical compound C=CC1CCCCOC1=O KSLINXQJWRKPET-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 description 1
- 208000003014 Bites and Stings Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241000195480 Fucus Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241001466453 Laminaria Species 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 description 1
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 description 1
- 235000010407 ammonium alginate Nutrition 0.000 description 1
- 239000000728 ammonium alginate Substances 0.000 description 1
- KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000011557 critical solution Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000003232 mucoadhesive effect Effects 0.000 description 1
- SWPMNMYLORDLJE-UHFFFAOYSA-N n-ethylprop-2-enamide Chemical compound CCNC(=O)C=C SWPMNMYLORDLJE-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920003226 polyurethane urea Polymers 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- AVWRKZWQTYIKIY-UHFFFAOYSA-N urea-1-carboxylic acid Chemical group NC(=O)NC(O)=O AVWRKZWQTYIKIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Composition hémostatique et cicatrisante, caractérisée en ce qu'elle se présente sous forme aqueuse et thermo-gélifiable, et en ce qu'elle comprend un mélange d'Aloe vera, d'un sel d'alginate soluble dans l'eau, et d'un polymère thermo-gélifiant soluble dans l'eau.Hemostatic and healing composition, characterized in that it is in aqueous and thermo-gelable form, and in that it comprises a mixture of Aloe vera, a water-soluble salt of alginate, and a thermo-gelling polymer soluble in water.
Description
Composition hémostatique et cicatrisanteHaemostatic and healing composition
La présente invention a pour objet une composition hémostatique et cicatrisante. Cette composition est avantageusement utilisée dans le traitement des plaies et permet d’assurer une bonne hémostase et une bonne cicatrisation, ainsi qu’un apaisement rapide des douleurs en cas de brûlure de la peau ou de piqûre d’insecte.The present invention relates to a haemostatic and healing composition. This composition is advantageously used in the treatment of wounds and ensures good haemostasis and good healing, as well as a rapid relief of pain in case of burning of the skin or insect sting.
La peau assure de nombreuses fonctions, en particulier la protection contre les éléments extérieurs. Une brûlure ou une plaie entraîne la rupture de ces fonctions, qui sont rétablies lors de la cicatrisation.The skin provides many functions, especially protection against external elements. A burn or wound breaks these functions, which are restored during healing.
Il apparaît ainsi souhaitable de disposer de compositions ayant une action hémostatique et cicatrisante satisfaisante et permettant d’apaiser les douleurs en cas de brûlure ou de piqûre.It thus appears desirable to have compositions having a haemostatic and healing effect satisfactory and to soothe pain in case of burning or sting.
La présente invention vise à atteindre ces objectifs. L’invention a ainsi pour objet une composition hémostatique et cicatrisante.The present invention aims to achieve these objectives. The subject of the invention is thus a hemostatic and healing composition.
La composition selon l’invention se présente sous forme aqueuse et thermo-gélifiable, en particulier lors du contact avec la peau, et comprend un mélange d’Aloe vera, d’un sel d’alginate soluble dans l’eau, et d’un polymère thermo-gélifiant soluble dans l’eau.The composition according to the invention is in an aqueous and thermogelifiable form, in particular when in contact with the skin, and comprises a mixture of Aloe Vera, a water-soluble alginate salt, and a thermo-gelling polymer soluble in water.
Ainsi, avantageusement, le polymère thermo-gélifiant permet la gélification du produit au contact de la peau, du fait de la différence de température entre la température ambiante et la température de la peau. Le gel obtenu permet de traiter localement la zone d’application de la composition, puisqu’il ne coule pas en dehors de cette zone. L’association spécifique de YAloe vera et du sel d’alginate soluble dans l’eau permet de procurer un apaisement des douleurs provoquées par des brûlures ou piqûres. Elle permet également un arrêt du saignement et favorise grandement la cicatrisation. L’utilisation de la composition est préconisée sur les brûlures superficielles, par exemples domestiques, ou en cas de coup de soleil du premier et du deuxième degré, sur les blessures superficielles de la vie courante, par application directe de la composition sur la zone blessée.Thus, advantageously, the thermo-gelling polymer allows the gelation of the product in contact with the skin, because of the temperature difference between the ambient temperature and the skin temperature. The gel obtained makes it possible to locally treat the zone of application of the composition, since it does not flow outside this zone. The specific combination of YAloe vera and water-soluble alginate salt helps to soothe pain caused by burns or punctures. It also stops bleeding and greatly promotes healing. The use of the composition is recommended on superficial burns, for example domestic, or in case of sunburn of the first and second degree, on superficial injuries of everyday life, by direct application of the composition on the injured area .
La composition est non invasive, destinée à un usage à court terme et présente un risque faible d’irritation ou de sensibilisation. La composition est considérée comme un dispositif de classe Mb selon la règle 4 de l’annexe IX de la Directive 93-42-CEE.The composition is non-invasive, intended for short-term use and has a low risk of irritation or sensitization. The composition is considered a class Mb device according to Rule 4 of Annex IX of Directive 93-42-EEC.
La composition selon l’invention permet de stopper les saignements, d’apaiser rapidement les brûlures ainsi que les douleurs liées aux piqûres d’insectes. Elle a l’effet d’une barrière entre la peau lésée et le milieu extérieure. Elle participe également au processus de cicatrisation. L’Aloe vera peut se présenter sous forme de poudre ou de gel, notamment de gel concentré.The composition according to the invention makes it possible to stop the bleeding, to quickly soothe the burns as well as the pains related to insect bites. It has the effect of a barrier between the damaged skin and the external environment. It also participates in the healing process. Aloe vera can be in the form of powder or gel, especially concentrated gel.
La poudre peut être obtenue par lyophilisation de gel d’Aloe vera.The powder can be obtained by lyophilization of Aloe Vera gel.
Par exemple, les feuilles d'Aloe vera peuvent être pelées pour obtenir le filet (la partie interne gélatineuse), qui est rincé pour éliminer le latex contenant l’aloïne, composé irritant et très laxatif. Le filet peut ensuite être broyé pour obtenir le jus d'Aloe vera qui est concentré. Ce gel concentré peut être séché par lyophilisation pour obtenir la poudre.For example, Aloe vera leaves can be peeled to obtain the netting (the gelatinous inner part), which is rinsed to remove the latex containing the aloin, an irritant and very laxative compound. The tenderloin can then be crushed to obtain the Aloe vera juice that is concentrated. This concentrated gel can be dried by lyophilization to obtain the powder.
Le sel d’alginate soluble dans l’eau est de préférence un sel monovalent, typiquement de l’alginate de sodium, de l’alginate de potassium, de l’alginate de lithium ou encore de l’alginate d’ammonium. L'acide alginique et ses dérivés (base conjuguée, sels et esters) les alginates sont des polysaccharides principalement obtenus à partir d'une famille d'algues brunes : les laminaires ou les fucus. L'alginate est le nom commun pour une famille de polymères formés de deux monomères liés ensemble : le mannuronate ou acide mannuronique et le guluronate ou acide guluronique.The water-soluble alginate salt is preferably a monovalent salt, typically sodium alginate, potassium alginate, lithium alginate or ammonium alginate. Alginic acid and its derivatives (base conjugates, salts and esters) alginates are polysaccharides mainly obtained from a family of brown algae: laminaria or fucus. Alginate is the common name for a family of polymers consisting of two monomers bonded together: mannuronate or mannuronic acid and guluronate or guluronic acid.
La formule générale de l’alginate est la suivante :The general formula of alginate is as follows:
La proportion et la distribution de ces deux monomères sont déterminantes pour une large expansion des propriétés physiques et chimiques de l'alginate, on parle ainsi de rapport mannuronique gluronique ou encore de rapport M/G. Sa composition chimique varie selon les diverses espèces d'algues, les différentes parties de la même plante et est sujette aux changements saisonniers. Néanmoins, par sélection de matières premières aux différentes propriétés, il est possible de fabriquer une variété d'alginate aux caractéristiques constantes.The proportion and distribution of these two monomers are decisive for a broad expansion of the physical and chemical properties of alginate, so-called gluronic mannuronic ratio or M / G ratio. Its chemical composition varies among different species of algae, different parts of the same plant and is subject to seasonal changes. Nevertheless, by selecting raw materials with different properties, it is possible to manufacture a variety of alginate with constant characteristics.
Les produits à base d’alginate ont des propriétés intrinsèques, naturelles, très efficaces contre le traitement des plaies. Ces produits sont en particulier destinés à l’hémostase et à la cicatrisation.Alginate products have intrinsic, natural, very effective properties against wound treatment. These products are in particular intended for hemostasis and cicatrization.
On entend par « polymère thermo-gélifiant >> un polymère qui, à faible concentration dans l'eau, se présente sous forme liquide (faible viscosité) à température ambiante et qui gélifie à la température corporelle, le phénomène de thermo-gélification étant parfaitement réversible. Par « température ambiante >>, on entend une température comprise entre 18 et 25°C.The term "thermo-gelling polymer" means a polymer which, at low concentration in water, is in liquid form (low viscosity) at room temperature and which gels at body temperature, the phenomenon of thermo-gelling being perfectly reversible. By "ambient temperature" is meant a temperature of between 18 and 25 ° C.
Le polymère thermo-gélifiant peut être choisi parmi la famille des polyéthers, des copolymères de vinylcaprolactone ou des polyacrylamides.The thermo-gelling polymer may be chosen from the family of polyethers, copolymers of vinylcaprolactone or polyacrylamides.
Les polymères thermo-gélifiants utilisables aux fins de l’invention peuvent comprendre, d'une part, des unités hydrosolubles et, d'autre part, des unités présentant dans l'eau une température inférieure critique de démixtion (appelée en abrégé « LCST >> pour « lower critical solution température >>). En dessous de la LCST, le polymère est parfaitement soluble dans l'eau, alors qu'au-dessus de cette température les portions à LCST s'associent et perdent leur solubilité dans l'eau, formant ainsi des noeuds de réticulation entre les chaînes polymères. Le polymère s'apparente alors à un réseau tridimensionnel, ce qui conduit à l'obtention d'un gel. Cette association de chaînes à LCST au sein des micro-domaines hydrophobes au-delà de la température de démixtion étant de nature physique, le phénomène de gélification est alors parfaitement réversible. Cette propriété de gélification avec la température n'est possible que si la concentration en polymère est supérieure à la concentration micellaire critique pour permettre des interactions entre les unités à LCST portées par des chaînes polymères différentes.The thermo-gelling polymers that may be used for the purposes of the invention may comprise, on the one hand, water-soluble units and, on the other hand, units having in water a lower critical demixing temperature (abbreviated as "LCST"). > for "lower critical solution temperature"). Below the LCST, the polymer is perfectly soluble in water, while above this temperature the LCST portions combine and lose their solubility in water, thus forming cross-linking nodes between the chains. polymers. The polymer then resembles a three-dimensional network, which leads to obtaining a gel. This association of LCST chains within the hydrophobic micro-domains beyond the demixing temperature being of a physical nature, the gelling phenomenon is then perfectly reversible. This gelation property with temperature is only possible if the polymer concentration is greater than the critical micelle concentration to allow interactions between the LCST units carried by different polymer chains.
Les polymères utilisés dans l'invention peuvent être aussi bien des polymères à blocs ou des polymères greffés qui comprennent, d'une part, des unités hydrosolubles et d'autre part des unités à LCST. Ces unités hydrosolubles peuvent être des polymères d'origine naturelle ou d'origine synthétique obtenus par polymérisation en chaîne ou par polycondensation.The polymers used in the invention may be either block polymers or graft polymers which comprise, on the one hand, water-soluble units and, on the other hand, units with an LCST. These water-soluble units may be polymers of natural origin or of synthetic origin obtained by chain polymerization or by polycondensation.
Les unités à LCST seront préférentiellement choisies parmi : - les polyéthers tels que le poly(oxyde de propylène) (POP) et ses copolymères statistiques et à blocs avec le poly(oxyde d'éthylène) (POE), - les dérivés N-substitués de l'acrylamide comme le poly(N-isopropylacrylamide) ou le poly(N-éthylacrylamide), - le polyvinylcaprolactame et les copolymères de vinylcaprolactame.The units with an LCST will preferably be chosen from: polyethers such as poly (propylene oxide) (POP) and its random and block copolymers with poly (ethylene oxide) (POE), N-substituted derivatives acrylamide such as poly (N-isopropylacrylamide) or poly (N-ethylacrylamide), polyvinylcaprolactam and copolymers of vinylcaprolactam.
Les polymères thermogélifiants susceptibles de convenir à l'invention peuvent être, par exemple, choisis parmi ceux décrits dans les demandes de brevets et brevets suivants : FR2694939, FR2788008, FR2820976, FR2856923, GB2408510, EP0629649, EP1307501, EPI407791, W097/00275, WO98/06438, W098/29487, W098/48768, W098/50005, WOOO/00222, WOOO/07603, WOOO/35961, WOOO/38851, WO01/41735, W002/032560, WO02/076392, W003/008462, WO03/106536, W004/006872, US2003/0099709, US6645476, US6689855, US6689856, US6870012 et US6878754.The thermogelling polymers that may be suitable for the invention may be, for example, chosen from those described in the following patent applications and patents: FR2694939, FR2788008, FR2820976, FR2856923, GB2408510, EP0629649, EP1307501, EPI407791, WO97 / 00275, WO98 / 06438, WO98 / 29487, WO98 / 48768, WO98 / 50005, WO00 / 00222, WO00 / 07603, WO00 / 35961, WO00 / 38851, WO01 / 41735, WO02 / 032560, WO02 / 076392, WO00 / 008462, WO03 / 106536 , W004 / 006872, US2003 / 0099709, US6645476, US6689855, US6689856, US6870012 and US6878754.
Les polymères thermogélifiants particulièrement adaptés sont les polyuréthanes comportant des groupements poly(oxyde d'éthylène-b-oxyde de propylène-b-oxyde d'éthylène) (POE-b-POP-b-POE) tels que ceux décrits dans les brevets et les demandes de brevets FR2840907, EP692506, EP1407791, WO 03 106536, US 7339013.Particularly suitable thermogelling polymers are polyurethanes comprising poly (ethylene oxide-b-propylene oxide-b-ethylene oxide) (POE-b-POP-b-POE) groups such as those described in the patents and patent applications FR2840907, EP692506, EP1407791, WO 03 106536, US 7339013.
Ces polyuréthanes sont obtenus par polycondensation de diisocyanates et de diols triblocs POE-b-POP-b-POE thermosensibles en milieu non anhydre et peuvent comprendre des groupements urée et/ou allophanates. Ces polymères, connus sous le nom d'ExpertGel® et commercialisés par la société PolymerExpert, présentent de nombreux avantages, en particulier: une faible concentration de polymères est nécessaire pour une augmentation importante de la viscosité en fonction de la température, ils présentent des propriétés lubrifiantes importantes, ils sont muco-adhésifs, - ils présentent le même comportement thermogélifiant dans une gamme de pH allant de 1 à 12, ils sont compatibles avec les sels, tensio-actifs et la plupart des excipients pharmaceutiques et cosmétiques. A titre d’exemple, on peut citer le polymère thermo-gélifiant EG230, qui est un polyuréthane ramifié contenant des unités POE-b-POP-b-POE, dont la désignation INCI (International Nomenclature of Cosmetic Ingrédients) en langue anglaise est Bis-Methoxy PEG-13 PEG-502/PPG-57 SMDI Copolymer.These polyurethanes are obtained by polycondensation of diisocyanates and POE-b-POP-b-POE triblock diols which are thermosensitive in a non-anhydrous medium and may comprise urea and / or allophanate groups. These polymers, known under the name of ExpertGel® and marketed by the company PolymerExpert, have many advantages, in particular: a low concentration of polymers is necessary for a significant increase in the viscosity as a function of the temperature, they have properties important lubricants, they are muco-adhesive, - they exhibit the same thermogelling behavior in a pH range from 1 to 12, they are compatible with salts, surfactants and most pharmaceutical and cosmetic excipients. By way of example, mention may be made of the thermo-gelling polymer EG230, which is a branched polyurethane containing POE-b-POP-b-POE units, whose INCI designation (International Nomenclature of Cosmetic Ingredients) in the English language is Bis -Methoxy PEG-13 PEG-502 / PPG-57 SMDI Copolymer.
On peut également citer le polymère thermo-gélifiant EG56, qui est un polyuréthane-urée à base de POE-POP-POE contenant environ 75% de POE, dont la désignation INCI (International Nomenclature of Cosmetic Ingrédients) en langue anglaise est Bis-Methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer.Mention may also be made of the thermo-gelling polymer EG56, which is a polyurethane-urea based on POE-POP-POE containing about 75% POE, whose INCI designation (International Nomenclature of Cosmetic Ingredients) in the English language is Bis-Methoxy PEG-13 PEG-438 / PPG-110 SMDI Copolymer.
La teneur en Aloe vera peut être comprise entre 0.01 et 10 % du poids total de la composition, et de préférence entre 0.01 et 2 % du poids total de la composition.The Aloe vera content may be between 0.01 and 10% of the total weight of the composition, and preferably between 0.01 and 2% of the total weight of the composition.
La teneur en sel d’alginate soluble dans l’eau peut être comprise entre 0.1 et 15 % du poids total de la composition, et de préférence entre 0.5 et 8 % du poids total de la composition.The water-soluble alginate salt content may be between 0.1 and 15% of the total weight of the composition, and preferably between 0.5 and 8% of the total weight of the composition.
Le rapport en poids du poids du sel d’alginate soluble dans l’eau sur le poids de YAloe vera peut être compris entre 1.5 et 100, et de préférence entre 4 et 50.The weight ratio of the weight of the water-soluble alginate salt to the weight of Aloe vera can be from 1.5 to 100, and preferably from 4 to 50.
La teneur en polymère thermo-gélifiant soluble dans l’eau peut être comprise entre 1 et 10 % du poids total de la composition, et de préférence entre 3 et 8 % du poids total de la composition.The content of thermo-gelling polymer soluble in water may be between 1 and 10% of the total weight of the composition, and preferably between 3 and 8% of the total weight of the composition.
La composition peut également comprendre du chlorure de sodium (en tant que liant, épaississant et agent masquant), du sorbate de potassium (en tant que conservateur), du chlorure de benzaikonium (en tant que conservateur, agent antibactérien, antiseptique), du menthol (sensation de fraîcheur), de l’éosine (en tant que colorant, antiseptique) ou encore de la chlorophylline (en tant que colorant, antioxydant), ou une combinaison de ces composés.The composition may also comprise sodium chloride (as binder, thickener and masking agent), potassium sorbate (as a preservative), benzaikonium chloride (as preservative, antibacterial agent, antiseptic), menthol (feeling of freshness), eosin (as a dye, antiseptic) or chlorophyllin (as a dye, antioxidant), or a combination of these compounds.
La composition peut se présenter sous différentes formes ou conditionnements, et notamment sous la forme d’un aérosol, d’une ampoule, notamment à fond souple, d’une enveloppe munie d’une zone sécable, d’un tube, ou encore d’un flacon. L’invention a également pour objet une composition décrite ci-dessus pour une utilisation hémostatique, cicatrisante, et/ou apaisante. L’invention est illustrée de manière non limitative par l’exemple qui suit. Les pourcentages sont exprimés en poids.The composition may be in various forms or packages, and especially in the form of an aerosol, an ampoule, especially a flexible bottom, an envelope provided with a breakable zone, a tube, or alternatively 'a flask. The invention also relates to a composition described above for hemostatic, healing, and / or soothing use. The invention is illustrated in a nonlimiting manner by the following example. The percentages are expressed by weight.
Exemple : préparation d’une composition hémostatique, cicatrisante et apaisante pouvant être déposée sous forme d’aérosol sur la peauExample: preparation of a haemostatic, healing and soothing composition that can be deposited in the form of an aerosol on the skin
On prépare la composition aqueuse thermo-gélifiante suivante :The following thermo-gelling aqueous composition is prepared:
La composition est préparée de la manière suivante. On met en solution le polymère commercialisé sous la dénomination ExpertGel® 230 (EG230) par la société PolymerExpert dans le volume d’eau déminéralisée adapté, sous agitation mécanique à 400 tours/mn, pendant 40 minutes. Le polymère EG230 voit sa solubilité augmentée dans l’eau froide. Une fois le polymère EG230 solubilisé, on ajoute l’alginate de sodium sous agitation à 500 tours/mn pendant 20 minutes. On ajoute successivement la glycérine et NaCI, avec la même agitation, pendant respectivement 5 et 10 minutes. Pour terminer, on met en solution YAloe vera pendant 10 minutes à 500 tours/mn. La solution est prête et est stérilisée rapidement ou conservée au réfrigérateur pour éviter la contamination (présence de matière végétale, Aloe vera et alginate, se contaminant facilement dans l’eau).The composition is prepared in the following manner. The polymer marketed under the name ExpertGel® 230 (EG230) is dissolved by PolymerExpert in the volume of demineralized water adapted, with mechanical stirring at 400 rpm, for 40 minutes. The EG230 polymer has its solubility increased in cold water. Once the EG230 polymer solubilized, the sodium alginate is added with stirring at 500 rpm for 20 minutes. Glycerol and NaCl are added successively, with the same stirring, for 5 and 10 minutes, respectively. Finally, YAloe vera solution is dissolved for 10 minutes at 500 rpm. The solution is ready and is sterilized quickly or stored in the refrigerator to avoid contamination (presence of plant material, Aloe vera and alginate, easily contaminating in water).
Le polymère ExpertGel® 230 ou EG230, est un polymère semi-cristallin thermo-gélifiant. Il est filmogène, non irritant, avec un pH compris entre 6 et 8 et est donc compatible avec le pH de la peau. L’alginate de sodium est un agent épaississant et gélifiant qui permet d’augmenter la viscosité de la composition.The ExpertGel® 230 or EG230 polymer is a semi-crystalline thermo-gelling polymer. It is film-forming, non-irritating, with a pH between 6 and 8 and is therefore compatible with the pH of the skin. Sodium alginate is a thickening and gelling agent which makes it possible to increase the viscosity of the composition.
La glycérine a la propriété d’être humectante, émolliente et aussi hydratante. Elle améliore donc l’onctuosité et la lubrification de la composition. La glycérine permet aussi de diminuer la température de gélation de l’EG230.Glycerine has the property of being moisturizing, emollient and also moisturizing. It therefore improves the lubricity and lubrication of the composition. Glycerin also reduces the freezing temperature of EG230.
Le chlorure de sodium (NaCI) agit comme liant, épaississant et agent masquant. Tout comme la glycérine, le chlorure de sodium diminue la température de gélation de l’EG230. L’Aloe vera présente de nombreuses propriétés. Il est à la fois filmogène, antibactérien, antifongique, émollient, humectant, adoucissant et anti-irritant et hydratant.Sodium chloride (NaCl) acts as a binder, thickener and masking agent. Like glycerine, sodium chloride lowers the freezing temperature of EG230. Aloe vera has many properties. It is both film-forming, antibacterial, antifungal, emollient, humectant, softening and anti-irritant and moisturizing.
La quantité de chaque constituant est avantageusement choisie pour que la composition soit soluble dans son contenant, puisse ainsi être expulsée sous forme d’aérosol et gélifier rapidement sur la peau. Les composants actifs sont présents en quantité suffisante au regard de l’application visée.The amount of each constituent is advantageously chosen so that the composition is soluble in its container, can thus be expelled in aerosol form and quickly gel on the skin. The active components are present in sufficient quantity with regard to the intended application.
Une étude in vitro est menée avec la création d’une lésion d’un tapis cellulaire de fibroblaste (cellules du derme). La composition préparée ci-dessus est appliquée sur la lésion et un suivi au cours du temps est réalisé. On applique également sur la lésion la même composition, mais sans alginate, et un suivi au cours du temps est réalisé. 48 heures après la lésion, on constate que la cicatrisation est totale avec la composition selon l’invention, tandis que la cicatrisation n’est que partielle avec une composition sans alginate.An in vitro study is conducted with the creation of a lesion of a fibroblast cell mat (dermal cells). The composition prepared above is applied to the lesion and monitoring over time is achieved. The same composition is also applied to the lesion, but without alginate, and monitoring over time is performed. 48 hours after the lesion, it is found that the cicatrization is total with the composition according to the invention, while the healing is only partial with a composition without alginate.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101739A (en) * | 1992-04-30 | 1995-12-08 | Vnii Med Polimerov | Pharmaceutical compositions comprising alginic acid and a metal compound for use in the treatment of gastroenteritic diseases wounds and burns as well as a hemostatic agent |
| WO2002009064A1 (en) * | 2000-07-21 | 2002-01-31 | L'oreal | Polymer comprising water soluble units and lcst units, and aqueous composition comprising same |
| WO2005007717A1 (en) * | 2003-07-18 | 2005-01-27 | Agency For Science, Technology And Research | Thermosensitive polymers for therapeutic use and methods of preparation |
| US20140377195A1 (en) * | 2011-12-22 | 2014-12-25 | Bioative Tecnologia Em Polimeros Ltda-Me | Polymer composition containing natural bioactive principles for use in pharmaceutical and cosmetic formulations |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101739A (en) * | 1992-04-30 | 1995-12-08 | Vnii Med Polimerov | Pharmaceutical compositions comprising alginic acid and a metal compound for use in the treatment of gastroenteritic diseases wounds and burns as well as a hemostatic agent |
| WO2002009064A1 (en) * | 2000-07-21 | 2002-01-31 | L'oreal | Polymer comprising water soluble units and lcst units, and aqueous composition comprising same |
| WO2005007717A1 (en) * | 2003-07-18 | 2005-01-27 | Agency For Science, Technology And Research | Thermosensitive polymers for therapeutic use and methods of preparation |
| US20140377195A1 (en) * | 2011-12-22 | 2014-12-25 | Bioative Tecnologia Em Polimeros Ltda-Me | Polymer composition containing natural bioactive principles for use in pharmaceutical and cosmetic formulations |
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