FR2578165A1 - New ointments with anti-cellulitis activity - Google Patents
New ointments with anti-cellulitis activity Download PDFInfo
- Publication number
- FR2578165A1 FR2578165A1 FR8500827A FR8500827A FR2578165A1 FR 2578165 A1 FR2578165 A1 FR 2578165A1 FR 8500827 A FR8500827 A FR 8500827A FR 8500827 A FR8500827 A FR 8500827A FR 2578165 A1 FR2578165 A1 FR 2578165A1
- Authority
- FR
- France
- Prior art keywords
- ointments
- cellulitis
- activity
- new
- mother tincture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 16
- 206010007882 Cellulitis Diseases 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 229940098465 tincture Drugs 0.000 claims abstract description 12
- 241000195480 Fucus Species 0.000 claims abstract description 6
- 240000008669 Hedera helix Species 0.000 claims abstract description 6
- 229940093797 bioflavonoids Drugs 0.000 claims abstract description 4
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims description 6
- 208000035484 Cellulite Diseases 0.000 claims description 4
- 206010049752 Peau d'orange Diseases 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 2
- 229930003949 flavanone Natural products 0.000 claims description 2
- 235000011981 flavanones Nutrition 0.000 claims description 2
- 229930003944 flavone Natural products 0.000 claims description 2
- 150000002212 flavone derivatives Chemical class 0.000 claims description 2
- 235000011949 flavones Nutrition 0.000 claims description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 2
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 claims 1
- 229930014669 anthocyanidin Natural products 0.000 claims 1
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims 1
- 235000008758 anthocyanidins Nutrition 0.000 claims 1
- 150000002207 flavanone derivatives Chemical class 0.000 claims 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 claims 1
- 150000007946 flavonol Chemical class 0.000 claims 1
- 235000011957 flavonols Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 abstract description 5
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 6
- 239000000686 essence Substances 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 4
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 description 3
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 3
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 3
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 3
- 229930019673 naringin Natural products 0.000 description 3
- 229940052490 naringin Drugs 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 3
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 3
- 235000005493 rutin Nutrition 0.000 description 3
- 229960004555 rutoside Drugs 0.000 description 3
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
- XNLFHCPVTULKIV-VAWYXSNFSA-N (e)-3-(4-methylphenyl)-1-phenylprop-2-en-1-one Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)C1=CC=CC=C1 XNLFHCPVTULKIV-VAWYXSNFSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 230000036232 cellulite Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229940100242 glycol stearate Drugs 0.000 description 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- -1 llHeperidine Chemical compound 0.000 description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- RLWHOZIEQDIKQF-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol;octadecanoic acid Chemical class CC(O)COC(C)COC(C)CO.CCCCCCCCCCCCCCCCCC(O)=O RLWHOZIEQDIKQF-UHFFFAOYSA-N 0.000 description 1
- GNKZMNRKLCTJAY-UHFFFAOYSA-N 4'-Methylacetophenone Chemical compound CC(=O)C1=CC=C(C)C=C1 GNKZMNRKLCTJAY-UHFFFAOYSA-N 0.000 description 1
- GZSOSUNBTXMUFQ-NJGQXECBSA-N 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside Natural products O(C[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4cc(O)c(OC)cc4)Oc3c2)O1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 GZSOSUNBTXMUFQ-NJGQXECBSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 229930183217 Genin Natural products 0.000 description 1
- 241000208341 Hedera Species 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 235000013628 Lantana involucrata Nutrition 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 240000004658 Medicago sativa Species 0.000 description 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
- 241000213996 Melilotus Species 0.000 description 1
- 235000000839 Melilotus officinalis subsp suaveolens Nutrition 0.000 description 1
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 1
- YXOLAZRVSSWPPT-UHFFFAOYSA-N Morin Chemical compound OC1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 YXOLAZRVSSWPPT-UHFFFAOYSA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 240000007673 Origanum vulgare Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229930015036 aurone Natural products 0.000 description 1
- 150000001530 aurones Chemical class 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- GZSOSUNBTXMUFQ-YFAPSIMESA-N diosmin Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 GZSOSUNBTXMUFQ-YFAPSIMESA-N 0.000 description 1
- 229960004352 diosmin Drugs 0.000 description 1
- IGBKNLGEMMEWKD-UHFFFAOYSA-N diosmin Natural products COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 IGBKNLGEMMEWKD-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 150000002208 flavanones Chemical class 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
- 239000001165 hyssopus officinalis l. extract Substances 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 235000007708 morin Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229930192880 rhoifoline Natural products 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Dans sa demande de brevet français 72.39351 déposée le 7 Novembre 1972 sous le titre "Nouvelle pommade à action anti-cellulithique, le déposant a décrit une nouvelle pommade ayant une action contre la cellulite. In his French patent application 72.39351 filed on November 7, 1972 under the title "New ointment with anti-cellulithic action, the applicant described a new ointment having an action against cellulite.
Cette pommade est caractérisée en ce qu'elle contient à titre de principes actifs d'une part une dilution de Folliculinum 3CH et, d'aute part, des teintures mères d'Hedera helix et de Fucus vesiculorum. Cette pommade peut en outre être additionnée d'audres ingrédients actifs tels que des essences aromatiques qui ont une action tonique sur la circulation dans les vaisseaux lymphatiques. This ointment is characterized in that it contains as active ingredients on the one hand a dilution of Folliculinum 3CH and, on the other hand, mother tinctures of Hedera helix and Fucus vesiculorum. This ointment can also be supplemented with other active ingredients such as aromatic essences which have a tonic action on the circulation in the lymphatic vessels.
Dans un premier certificat d'addition déposé le 20Juillet 1984 sous le numéro 84/ 11505 , la demanderesse a constate que la dilution de Folliculinum 3CH pouvait avantageusement être remplacée par un extrait végétal renfermant ou contenant des principes actifs doués de propriétés estrogènes comme l'extrait de houblon, de saule, feuilles d'olivier, de graines de coton, l'extrait de luzerne ou l'extrait de melilot. In a first certificate of addition filed on July 20, 1984 under number 84/11505, the plaintiff noted that the dilution of Folliculinum 3CH could advantageously be replaced by a plant extract containing or containing active principles endowed with estrogenic properties such as the extract hops, willow, olive leaves, cotton seeds, alfalfa extract or sweet clover extract.
Or, la demanderesse a trouvé maintenant que la dilution Folliculinum 3CH pouvait également être remplacée par un extrait de plante riche en substances flavoniques ou, mieux encore, par une substance flavonique pure. However, the Applicant has now found that the Folliculinum 3CH dilution could also be replaced by a plant extract rich in flavonic substances or, better still, by a pure flavonic substance.
On désigne par substance flavonique ou bioflavonique un composé pur ou un mélange de composés chimiques doués de propriétés vitaminiques P, c'est-à-dire capables d'agir sur la capillarité, sur le tonus veineux et sur la résistance capillaire. Un certain nombre de ces substances est désigné sous le terme général de ci troflavonoides, car leur source principale se trouve dans les écorces d'Aurantiacées et en particulier dans les écorces de citrus tel que citron, orange, mandarine ou pamplemousse. The term flavonic or bioflavonic substance denotes a pure compound or a mixture of chemical compounds endowed with vitamin P properties, that is to say capable of acting on capillarity, on venous tone and on capillary resistance. A certain number of these substances is designated under the general term of ci troflavonoides, because their main source is found in the barks of Aurantiaceae and in particular in the peels of citrus such as lemon, orange, mandarin or grapefruit.
Les bioflavonoides, tout en constituant un groupe pharmacologique homogène, n'appartiennent pas à une classe chimique homogène. Bioflavonoids, while constituting a homogeneous pharmacological group, do not belong to a homogeneous chemical class.
Ce sont des genines ou des glucosides dérivés de flavanones, de :rla- vonols, de flavone, d'anthocyanines ou d'aurones
On peut donc utiliser dans le cadre de la présente addition un mélange de bioflavonoïdes comme un extrait d'écorces de citrons, de fruits du myrtillier ou de cassis, ou bien un produit pur défini comme la Naringine, llHepéridine, le Morin, le Kaempferol, la Lutéoline, la Rhoifoline, la Scutarelline, les Catéchines, la Diosmine, la Rutine, la Pelargonidine, la Quercitine, 1 'Eryodictol. They are genins or glucosides derived from flavanones,: rla-vonols, flavone, anthocyanins or aurones
It is therefore possible to use in the context of the present addition a mixture of bioflavonoids such as an extract of the peel of lemons, blueberry fruit or blackcurrant, or else a pure product defined as Naringin, llHeperidine, Morin, Kaempferol, Luteolin, Rhoifoline, Scutarellin, Catechins, Diosmin, Rutin, Pelargonidine, Quercitin, Eryodictol.
On peut également utiliser un mélange de deux ou plusieurs substances du groupe des bioflavonoldes. It is also possible to use a mixture of two or more substances from the group of bioflavonoldes.
La teneur en bioflavanoide peut varier dans des limites extensives en fonction du degré de perméabilité de la barrière cutanée à tel ou tel de ces principes actifs. D'une manière préférée, la teneur en bioflavonolde sera comprise entre 1 et 10%. The bioflavanoid content can vary within extensive limits depending on the degree of permeability of the skin barrier to one or other of these active ingredients. Preferably, the bioflavonold content will be between 1 and 10%.
Selon l'invention le bioflavonolde est réparti dans un excipient pour pommade auquel on incorpore si désiré un agent émulsionnant, un excipient gras naturel ou synthétique et de l'eau ou un véhicule aqueux en quantité suffisante pour former une pommade ou une crème d'onctuosité appropriée pour l'application ou le massage sur la partie du corps atteinte de cellulite. According to the invention, the bioflavonold is distributed in an ointment excipient to which an emulsifying agent, a natural or synthetic fatty excipient and water or an aqueous vehicle in sufficient quantity are incorporated if desired to form an ointment or cream for creaminess. suitable for application or massage on the part of the body affected by cellulite.
Parmi les agents émulsionnants appropriés, on citera plus particulièrement les esters d'acides gras et de polyalcool comme, par exemple, les stéarates de polyethylène glycol, les stéarates de diou tripropylène glycol, les amides d'acides gras comme les igepons, les brijs, les spans ou les tweens.Among the suitable emulsifying agents, mention will be made more particularly of fatty acid and polyalcohol esters such as, for example, polyethylene glycol stearates, diou tripropylene glycol stearates, fatty acid amides such as igepons, brijs, spans or tweens.
Les crèmes pourront en outre renfermer des agents de stabilisation, des agents anti-oxydants, des agents antibactériens, des agents antifongiques, des agents parfumants , odorants ou colorants.The creams may also contain stabilizing agents, antioxidant agents, antibacterial agents, antifungal agents, perfuming, odorous or coloring agents.
D'une manière préférée, il est particulièrement recommandé de préparer une crème fluide, peu onctueuse, non grasse au toucher, dont la pénétration dans les tissus est rapide sans risque de graisser le peau ou de laisser un dépôt coloré ou un résidu pulvérulent. In a preferred way, it is particularly recommended to prepare a fluid cream, not very creamy, non-greasy to the touch, the penetration of which into the tissues is rapid without risk of greasing the skin or of leaving a colored deposit or a pulverulent residue.
La pommade selon la présente addition est répartie en pots ou en tubes, en flacons plastiques souples ou bien encore en capsules molles de gélatine. Le choix du récipient ou du contenant se fait en fonction de la consistance de la préparation anti-cellulitique, de la surface d'application et de la dose à appliquer. The ointment according to the present addition is distributed in jars or tubes, in flexible plastic bottles or even in soft gelatin capsules. The choice of container or container is made according to the consistency of the anti-cellulite preparation, the application surface and the dose to be applied.
Les exemples suivants illustrent l'invention. Ils ne la limitent en aucune façon. The following examples illustrate the invention. They do not limit it in any way.
EXEMPLE I Crème å base de Naringine Naringine finement pulvérisée 2,50 -g Extrait de thym 0,400 g Extrait d'hyssope 0,300 g Teinture mère d'Hedera helix 4,75 g Teinture mère de Fueus vesiculorum 2,25 g Stéarate de polyethylene glycol 0,400 g Ruile de paraffine 2 g Essence de lavande 0,005 g Eau q.s.p. 100 g
EXEMPLE II
Crème à base de Rutine 0- -hydroxyethylée . 7-(hydroxyethyl) Rutine 3,75 g Teinture mère d'Hedera Helix 4,25 g Teinture mère de Fucus vesiculorum 3,50 g Stéarate de polyethylène glycol 0,400 g Pluronic F 18 0,100 g Ruile de paraffine 2 g Coumarine 0,025 g Eau q.s.p. 100 g
EXEMPLE III Pommade a base de d-catéchine
d-catéchine 1,80 g
Teinture d'Hedera helix 4,75 g
Teinture de Fucus vesiculorum 4 g
. Essence de thym 0,25 g
Lanoline 4 g
. Vaseline 4 g
Eau q.s.p. 100 g
EXEMPLE IV
Pommade à base d'Hesperidine ou d'Hesperidine methyl chalcone
. Hesperidine ou Hesperidine Methyl Chalcone 1,50 g
. Teinture d'Hedera heiix 2,25 g Teinture de Fucus vesiculorum 4 g
Essence d'Origan 0,60 g . Essence de Marjolaine 0,40 g Lanoline 10 g Vaseline 40 g EXAMPLE I Naringin cream Finely pulverized Naringin 2.50 -g Thyme extract 0.400 g Hyssop extract 0.300 g Mother tincture of Hedera helix 4.75 g Mother tincture of Fueus vesiculorum 2.25 g Polyethylene glycol stearate 0.400 g Paraffin oil 2 g Lavender essence 0.005 g Water qs 100 g
EXAMPLE II
Cream based on Rutin 0--hydroxyethylated. 7- (hydroxyethyl) Rutin 3.75 g Mother tincture of Hedera Helix 4.25 g Mother tincture of Fucus vesiculorum 3.50 g Polyethylene glycol stearate 0.400 g Pluronic F 18 0.100 g Paraffin oil 2 g Coumarin 0.025 g Water qs 100g
EXAMPLE III Ointment Based on D-Catechin
d-catechin 1.80 g
Hedera helix tincture 4.75 g
Tincture of Fucus vesiculorum 4 g
. Thyme essence 0.25 g
Lanolin 4 g
. Vaseline 4 g
Water qs 100 g
EXAMPLE IV
Ointment based on Hesperidine or Hesperidine methyl chalcone
. Hesperidine or Hesperidine Methyl Chalcone 1.50 g
. Tincture of Hedera heiix 2.25 g Tincture of Fucus vesiculorum 4 g
Essence of Oregano 0.60 g. Essence of Marjoram 0.40 g Lanolin 10 g Vaseline 40 g
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8500827A FR2578165B3 (en) | 1985-01-22 | 1985-01-22 | NEW POMEADS WITH ANTICELLULITIC ACTION. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8500827A FR2578165B3 (en) | 1985-01-22 | 1985-01-22 | NEW POMEADS WITH ANTICELLULITIC ACTION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2578165A1 true FR2578165A1 (en) | 1986-09-05 |
| FR2578165B3 FR2578165B3 (en) | 1987-12-18 |
Family
ID=9315467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8500827A Expired FR2578165B3 (en) | 1985-01-22 | 1985-01-22 | NEW POMEADS WITH ANTICELLULITIC ACTION. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2578165B3 (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687572A1 (en) * | 1992-02-26 | 1993-08-27 | Oreal | Use of certain flavonoids in cosmetic compositions, and process for protecting the skin, its exoskeleton and cosmetic compositions. |
| EP0573777A1 (en) * | 1992-05-11 | 1993-12-15 | INDENA S.p.A. | Oral pharmaceutical compositions containing anthocyanosides |
| ES2049661A1 (en) * | 1992-10-09 | 1994-04-16 | Imbeal S A Lab | Anti-cellulite compsn - contains mixt seaweed, algae, ivy and broom, with preservative in a substrate of fatty material and water |
| FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
| FR2774905A1 (en) * | 1998-02-17 | 1999-08-20 | Codif International Sa | Stimulation of lipolysis with cosmetic composition |
| WO1999047119A1 (en) * | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Methods for regulating skin appearance |
| FR2802088A1 (en) * | 1999-12-09 | 2001-06-15 | Fabre Pierre Dermo Cosmetique | Cosmetic compositions comprising hesperidine is obtained by extraction of citron, to protect skin, hair and maintain or restore luster |
| WO2001064177A1 (en) * | 2000-02-28 | 2001-09-07 | Henkel Kommanditgesellschaft Auf Aktien | Use of flavones or isoflavones for the treatment of cellulite |
| FR2825627A1 (en) * | 2001-06-06 | 2002-12-13 | Gattefosse Ets Sa | Citrus blossom bud extract with high citroflavonoid content, useful in cosmetic or pharmaceutical compositions, e.g. for protecting sensitive skin, treating acne, rosaceae or combating wrinkles |
| EP1541127A1 (en) * | 2003-12-10 | 2005-06-15 | L'oreal | Use of modulators of aquaglyceroporins as slimming agents |
| FR2868701A1 (en) * | 2004-04-07 | 2005-10-14 | Provital S A Sa | Composition for controlling fat content and differentiation of adipocytes, useful for treating cellulite, comprising dihydroflavonol, e.g. dihydromyricetin |
| FR2919501A1 (en) * | 2007-08-02 | 2009-02-06 | Oreal | USE OF HESPERIDINE OR ONE OF ITS DERIVATIVES FOR THE PREVENTION AND / OR TREATMENT OF RELEASED SKIN |
| WO2009040851A1 (en) * | 2007-09-04 | 2009-04-02 | Chronolife S.R.L. | Topical formulation for the treatment of cellulite |
| EP2090290A1 (en) * | 2008-02-18 | 2009-08-19 | Beiersdorf AG | Use of 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxphenyl)-propan-1-on for improved skin contouring and countering cellulite |
| EP2813207A1 (en) * | 2013-05-24 | 2014-12-17 | Roberto Bianco | Anti-cellulite product based on natural essences |
-
1985
- 1985-01-22 FR FR8500827A patent/FR2578165B3/en not_active Expired
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687572A1 (en) * | 1992-02-26 | 1993-08-27 | Oreal | Use of certain flavonoids in cosmetic compositions, and process for protecting the skin, its exoskeleton and cosmetic compositions. |
| EP0573777A1 (en) * | 1992-05-11 | 1993-12-15 | INDENA S.p.A. | Oral pharmaceutical compositions containing anthocyanosides |
| ES2049661A1 (en) * | 1992-10-09 | 1994-04-16 | Imbeal S A Lab | Anti-cellulite compsn - contains mixt seaweed, algae, ivy and broom, with preservative in a substrate of fatty material and water |
| FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
| EP0681827A1 (en) * | 1994-05-05 | 1995-11-15 | L'oreal | Use of bioflavonoids as keratineous phaners protection agent |
| US5660818A (en) * | 1994-05-05 | 1997-08-26 | L'oreal | Bioflavonoids as agents for protecting the physical and/or cosmetic properties of keratinous superficial body growths |
| FR2774905A1 (en) * | 1998-02-17 | 1999-08-20 | Codif International Sa | Stimulation of lipolysis with cosmetic composition |
| WO1999047119A1 (en) * | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Methods for regulating skin appearance |
| US6235773B1 (en) | 1998-03-16 | 2001-05-22 | The Procter & Gamble Company | Compositions for regulating skin appearance |
| FR2802088A1 (en) * | 1999-12-09 | 2001-06-15 | Fabre Pierre Dermo Cosmetique | Cosmetic compositions comprising hesperidine is obtained by extraction of citron, to protect skin, hair and maintain or restore luster |
| WO2001064177A1 (en) * | 2000-02-28 | 2001-09-07 | Henkel Kommanditgesellschaft Auf Aktien | Use of flavones or isoflavones for the treatment of cellulite |
| FR2825627A1 (en) * | 2001-06-06 | 2002-12-13 | Gattefosse Ets Sa | Citrus blossom bud extract with high citroflavonoid content, useful in cosmetic or pharmaceutical compositions, e.g. for protecting sensitive skin, treating acne, rosaceae or combating wrinkles |
| EP1541127A1 (en) * | 2003-12-10 | 2005-06-15 | L'oreal | Use of modulators of aquaglyceroporins as slimming agents |
| FR2863492A1 (en) * | 2003-12-10 | 2005-06-17 | Oreal | USE OF AQUAGLYCEROPORIN MODULATORS AS SLIMMING |
| FR2868701A1 (en) * | 2004-04-07 | 2005-10-14 | Provital S A Sa | Composition for controlling fat content and differentiation of adipocytes, useful for treating cellulite, comprising dihydroflavonol, e.g. dihydromyricetin |
| FR2919501A1 (en) * | 2007-08-02 | 2009-02-06 | Oreal | USE OF HESPERIDINE OR ONE OF ITS DERIVATIVES FOR THE PREVENTION AND / OR TREATMENT OF RELEASED SKIN |
| WO2009022077A2 (en) | 2007-08-02 | 2009-02-19 | L'oreal | Use of hesperidin or of a derivative thereof for the prevention and/or treatment of slackened skin |
| WO2009022077A3 (en) * | 2007-08-02 | 2010-02-11 | L'oreal | Use of hesperidin or of a derivative thereof for the prevention and/or treatment of slackened skin |
| WO2009040851A1 (en) * | 2007-09-04 | 2009-04-02 | Chronolife S.R.L. | Topical formulation for the treatment of cellulite |
| US8501203B2 (en) | 2007-09-04 | 2013-08-06 | Chronolife S.R.L. | Topical formulation for the treatment of cellulite |
| EP2090290A1 (en) * | 2008-02-18 | 2009-08-19 | Beiersdorf AG | Use of 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxphenyl)-propan-1-on for improved skin contouring and countering cellulite |
| US8236859B2 (en) | 2008-02-18 | 2012-08-07 | Beiersdorf Ag | Use of 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl) propane-1-one for improved skin contouring or against cellulite |
| EP2813207A1 (en) * | 2013-05-24 | 2014-12-17 | Roberto Bianco | Anti-cellulite product based on natural essences |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2578165B3 (en) | 1987-12-18 |
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