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FR2363577A1 - Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur - Google Patents

Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur

Info

Publication number
FR2363577A1
FR2363577A1 FR7626640A FR7626640A FR2363577A1 FR 2363577 A1 FR2363577 A1 FR 2363577A1 FR 7626640 A FR7626640 A FR 7626640A FR 7626640 A FR7626640 A FR 7626640A FR 2363577 A1 FR2363577 A1 FR 2363577A1
Authority
FR
France
Prior art keywords
fibrinogen
concn
factor
ppte
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7626640A
Other languages
English (en)
Other versions
FR2363577B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECHERCHES HEMATOLOGIQUES
Original Assignee
RECHERCHES HEMATOLOGIQUES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECHERCHES HEMATOLOGIQUES filed Critical RECHERCHES HEMATOLOGIQUES
Priority to FR7626640A priority Critical patent/FR2363577A1/fr
Publication of FR2363577A1 publication Critical patent/FR2363577A1/fr
Application granted granted Critical
Publication of FR2363577B1 publication Critical patent/FR2363577B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention décrit un procédé rapide et simple pour obtenir un concentré de facteur antihémophilique (facteur VIII) pur. La principale opération consiste, après extraction du cryoprécipité dans un milieu aqueux à faible force ionique à la température ambiante, à précipiter le fibrinogène de la solution en refroidissant celle-ci entre 1 degrés -2 degrés C pendant au moins une demi-heure, puis à séparer le liquide surnageant, à le stabiliser, le clarifier, le stériliser et le lyophiliser pour sa conservation à long terme. Le produit pur obtenu peut facilement être dissous dans de l'eau distillée ou une solution saline physiologique. Il sert aux traitements des personnes hémophiles.
FR7626640A 1976-09-03 1976-09-03 Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur Granted FR2363577A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7626640A FR2363577A1 (fr) 1976-09-03 1976-09-03 Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7626640A FR2363577A1 (fr) 1976-09-03 1976-09-03 Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur

Publications (2)

Publication Number Publication Date
FR2363577A1 true FR2363577A1 (fr) 1978-03-31
FR2363577B1 FR2363577B1 (fr) 1980-05-09

Family

ID=9177361

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7626640A Granted FR2363577A1 (fr) 1976-09-03 1976-09-03 Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur

Country Status (1)

Country Link
FR (1) FR2363577A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440193A1 (fr) * 1978-11-01 1980-05-30 Nordisk Insulinlab Procede de production d'une preparation de facteur anti-hemophilique a partir de plasma de sang humain
FR2460305A2 (fr) * 1979-06-29 1981-01-23 Merieux Inst Procede de preparation d'un concentre de facteur viii
FR2473886A1 (fr) * 1980-01-18 1981-07-24 Merieux Inst Perfectionnement aux procedes de concentration et de purification du facteur anti-hemophilique (facteur viii) et preparations de facteur viii concentre et purifie obtenues
EP0083483A1 (fr) * 1981-12-14 1983-07-13 Scripps Clinic And Research Foundation Preparation de facteur VIII : C ultrapurifié
WO2004039382A1 (fr) * 2002-10-25 2004-05-13 Shanbrom Technologies, Llc Production amelioree de facteurs de coagulation par cryoprecipitation
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440193A1 (fr) * 1978-11-01 1980-05-30 Nordisk Insulinlab Procede de production d'une preparation de facteur anti-hemophilique a partir de plasma de sang humain
FR2460305A2 (fr) * 1979-06-29 1981-01-23 Merieux Inst Procede de preparation d'un concentre de facteur viii
WO1984000757A1 (fr) * 1979-06-29 1984-03-01 Jacques Liautaud Procede de preparation d'un concentre de facteur viii
FR2473886A1 (fr) * 1980-01-18 1981-07-24 Merieux Inst Perfectionnement aux procedes de concentration et de purification du facteur anti-hemophilique (facteur viii) et preparations de facteur viii concentre et purifie obtenues
EP0083483A1 (fr) * 1981-12-14 1983-07-13 Scripps Clinic And Research Foundation Preparation de facteur VIII : C ultrapurifié
AU2003295354B2 (en) * 2002-10-25 2008-04-03 Shanbrom Technologies, Llc Enhanced production of clotting factors by cryoprecipitation
WO2004039382A1 (fr) * 2002-10-25 2004-05-13 Shanbrom Technologies, Llc Production amelioree de facteurs de coagulation par cryoprecipitation
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11609043B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11740019B2 (en) 2019-03-14 2023-08-29 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11747082B2 (en) 2019-03-14 2023-09-05 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11815311B2 (en) 2019-03-14 2023-11-14 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11994343B2 (en) 2019-03-14 2024-05-28 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use

Also Published As

Publication number Publication date
FR2363577B1 (fr) 1980-05-09

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