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FR2313922A1 - Procede perfectionne pour preparer des esters d'alpha-methyl-3,4-dihydroxyphenylalanine - Google Patents

Procede perfectionne pour preparer des esters d'alpha-methyl-3,4-dihydroxyphenylalanine

Info

Publication number
FR2313922A1
FR2313922A1 FR7617236A FR7617236A FR2313922A1 FR 2313922 A1 FR2313922 A1 FR 2313922A1 FR 7617236 A FR7617236 A FR 7617236A FR 7617236 A FR7617236 A FR 7617236A FR 2313922 A1 FR2313922 A1 FR 2313922A1
Authority
FR
France
Prior art keywords
dihydroxyphenylalanine
esters
methyl
preparing alpha
perfected process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7617236A
Other languages
English (en)
French (fr)
Other versions
FR2313922B1 (da
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2313922A1 publication Critical patent/FR2313922A1/fr
Application granted granted Critical
Publication of FR2313922B1 publication Critical patent/FR2313922B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7617236A 1975-06-11 1976-06-08 Procede perfectionne pour preparer des esters d'alpha-methyl-3,4-dihydroxyphenylalanine Granted FR2313922A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58600775A 1975-06-11 1975-06-11

Publications (2)

Publication Number Publication Date
FR2313922A1 true FR2313922A1 (fr) 1977-01-07
FR2313922B1 FR2313922B1 (da) 1979-09-21

Family

ID=24343905

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7617236A Granted FR2313922A1 (fr) 1975-06-11 1976-06-08 Procede perfectionne pour preparer des esters d'alpha-methyl-3,4-dihydroxyphenylalanine

Country Status (7)

Country Link
JP (1) JPS51149241A (da)
DE (1) DE2626095A1 (da)
DK (1) DK229876A (da)
FR (1) FR2313922A1 (da)
GB (1) GB1518745A (da)
NL (1) NL7605698A (da)
SE (1) SE7605911L (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087680A1 (en) * 1982-03-01 1983-09-07 Merck & Co. Inc. Crystalline diastereomeric L-alpha-methyldopa POE ester
WO1986004579A1 (fr) * 1985-02-04 1986-08-14 Universite Catholique De Louvain Derives de l-dopa, leur preparation et compositions pharmaceutiques les contenant

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57112385A (en) * 1980-12-29 1982-07-13 Suntory Ltd Production of mugineic acids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244488A1 (da) * 1973-09-25 1975-04-18 Merck & Co Inc

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244488A1 (da) * 1973-09-25 1975-04-18 Merck & Co Inc

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087680A1 (en) * 1982-03-01 1983-09-07 Merck & Co. Inc. Crystalline diastereomeric L-alpha-methyldopa POE ester
WO1986004579A1 (fr) * 1985-02-04 1986-08-14 Universite Catholique De Louvain Derives de l-dopa, leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
DK229876A (da) 1976-12-12
NL7605698A (nl) 1976-12-14
DE2626095A1 (de) 1976-12-30
SE7605911L (sv) 1976-12-12
JPS51149241A (en) 1976-12-22
FR2313922B1 (da) 1979-09-21
GB1518745A (en) 1978-07-26

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Legal Events

Date Code Title Description
ST Notification of lapse