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FR2192812A1 - 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity - Google Patents

2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity

Info

Publication number
FR2192812A1
FR2192812A1 FR7226159A FR7226159A FR2192812A1 FR 2192812 A1 FR2192812 A1 FR 2192812A1 FR 7226159 A FR7226159 A FR 7226159A FR 7226159 A FR7226159 A FR 7226159A FR 2192812 A1 FR2192812 A1 FR 2192812A1
Authority
FR
France
Prior art keywords
local
anaesth
etic
amino
antitussive activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7226159A
Other languages
French (fr)
Other versions
FR2192812B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE ETD IND PHARMA
Original Assignee
CENTRE ETD IND PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CENTRE ETD IND PHARMA filed Critical CENTRE ETD IND PHARMA
Priority to FR7226159A priority Critical patent/FR2192812A1/en
Publication of FR2192812A1 publication Critical patent/FR2192812A1/en
Application granted granted Critical
Publication of FR2192812B1 publication Critical patent/FR2192812B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Title cpds. of formula: (where R1 is NH2 or the group OR where R is 1-4C alkyl; R2 and R3 are H or 1-4C alkyl, or R2 + R3 and the attached N-atom form a heterocyclic ring optically containing another heteroatom; X and Y are H, NO2 or halogen) their acid addn. and quaternary NH4 salts possess. Local anaesthetic activity similar to that of lignocaine hydrochloride. Unit doses of 20-250 mg of active component to a total of 20-2000 mg/day may be given.
FR7226159A 1972-07-20 1972-07-20 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity Granted FR2192812A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7226159A FR2192812A1 (en) 1972-07-20 1972-07-20 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7226159A FR2192812A1 (en) 1972-07-20 1972-07-20 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity

Publications (2)

Publication Number Publication Date
FR2192812A1 true FR2192812A1 (en) 1974-02-15
FR2192812B1 FR2192812B1 (en) 1975-08-08

Family

ID=9102126

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7226159A Granted FR2192812A1 (en) 1972-07-20 1972-07-20 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity

Country Status (1)

Country Link
FR (1) FR2192812A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0053435A1 (en) * 1980-11-28 1982-06-09 American Hospital Supply Corporation Compounds suitable for treatment or prophylaxis of cardiac disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523B (en) * 1962-02-15 1967-03-16 Sanol Arznei Schwarz Gmbh Process for the preparation of basic phenyl and naphthyl ethers and thioethers and their salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523B (en) * 1962-02-15 1967-03-16 Sanol Arznei Schwarz Gmbh Process for the preparation of basic phenyl and naphthyl ethers and thioethers and their salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0053435A1 (en) * 1980-11-28 1982-06-09 American Hospital Supply Corporation Compounds suitable for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
FR2192812B1 (en) 1975-08-08

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Legal Events

Date Code Title Description
ST Notification of lapse