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GB985747A - Cephalosporin compounds - Google Patents

Cephalosporin compounds

Info

Publication number
GB985747A
GB985747A GB3233062A GB3233062A GB985747A GB 985747 A GB985747 A GB 985747A GB 3233062 A GB3233062 A GB 3233062A GB 3233062 A GB3233062 A GB 3233062A GB 985747 A GB985747 A GB 985747A
Authority
GB
United Kingdom
Prior art keywords
ethyl
amino
methyl
hydrogen
acyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3233062A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB985747A publication Critical patent/GB985747A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporins of the formula <FORM:0985747/C2/1> wherein R1, taken alone, is -OH, C1-C8 acyloxy, or tertiary-amino; R2 is -OH when R1 is -OH; R2 is -OH when R1 is C1-C8 acyloxy R2 is -O- when R1 is tertiary-amino; R1 and R2, when taken together are -O-; R3 is C1-C4 alkyl, phenyl, naphthyl, thienyl, benzothienyl furyl, benzofuryl, indolyl, pyridyl, or a substitution product thereof having at least one substituent consisting of halogen, nitro, trifluoromethyl, C1-C4 alkyl or C1-C2 alkoxy; R4 is hydrogen, methyl or ethyl; R5 is hydrogen, methyl or ethyl; R6 is hydrogen, methyl or ethyl; m is 0 or 1; and n is 0 or 1; and the pharmaceutically acceptable salts, esters and amides thereof, may be prepared by reacting the relevant cephalosporin nucleus with the appropriate acylating agent. The Specification gives examples of many cephalosporins of the above formula, such as the optically active isomers of #c-aminophenyl-acetamido- and #c-amino - b - phenylpropionamido - cephalosporanic acid. Specifications 810,196, 912,360 and 912,541 are referred to.
GB3233062A 1961-09-11 1962-08-22 Cephalosporin compounds Expired GB985747A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13700061A 1961-09-11 1961-09-11

Publications (1)

Publication Number Publication Date
GB985747A true GB985747A (en) 1965-03-10

Family

ID=22475375

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3233062A Expired GB985747A (en) 1961-09-11 1962-08-22 Cephalosporin compounds

Country Status (4)

Country Link
BR (1) BR6242367D0 (en)
CH (1) CH433314A (en)
DE (1) DE1445685A1 (en)
GB (1) GB985747A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303193A (en) * 1965-11-24 1967-02-07 Bristol Myers Co Derivatives of cephalosporanic acid
GB2137993A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Improvements in or relating to naphthylglycyl cephalosporin derivatives
GB2137997A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Improvements in or relating to indolylglycyl cephalosporin derivatives
GB2137995A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
EP0122156A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303193A (en) * 1965-11-24 1967-02-07 Bristol Myers Co Derivatives of cephalosporanic acid
GB2137993A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Improvements in or relating to naphthylglycyl cephalosporin derivatives
GB2137997A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Improvements in or relating to indolylglycyl cephalosporin derivatives
GB2137995A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
EP0122154A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives
EP0122156A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives
GB2137996A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
EP0122157A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to indolylglycyl cephalosporin derivatives
EP0122155A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to naphthylglycyl cephalosporin derivatives
EP0122155A3 (en) * 1983-04-12 1985-07-31 Eli Lilly And Company Improvements in or relating to naphthylglycyl cephalosporin derivatives
EP0122157A3 (en) * 1983-04-12 1985-08-14 Eli Lilly And Company Improvements in or relating to indolylglycyl cephalosporin derivatives
EP0122154A3 (en) * 1983-04-12 1985-10-23 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives
EP0122156A3 (en) * 1983-04-12 1985-12-04 Eli Lilly And Company Improvements in or relating to benzothienylglycyl cephalosporin derivatives

Also Published As

Publication number Publication date
CH433314A (en) 1967-04-15
DE1445685A1 (en) 1968-12-05
BR6242367D0 (en) 1973-07-12

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