FR2159176A1 - Purification of vioform - crystallisation of presence of hydrogen peroxide and an acid - Google Patents
Purification of vioform - crystallisation of presence of hydrogen peroxide and an acidInfo
- Publication number
- FR2159176A1 FR2159176A1 FR7140137A FR7140137A FR2159176A1 FR 2159176 A1 FR2159176 A1 FR 2159176A1 FR 7140137 A FR7140137 A FR 7140137A FR 7140137 A FR7140137 A FR 7140137A FR 2159176 A1 FR2159176 A1 FR 2159176A1
- Authority
- FR
- France
- Prior art keywords
- acid
- vioform
- dmf
- crystallisation
- purification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title abstract 4
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 235000011054 acetic acid Nutrition 0.000 abstract 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001243 acetic acids Chemical class 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 150000004674 formic acids Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Vioform, 5-chloro-7-iodo-8-hydroxy quinoline (I), a known antiinfection agent, is purified by dissolving in DMF or dichloroethane and treatment with H2O2 and acetic or formic acids. 0.1-1 moles labile oxygen and 1-3 moles acid being used per mole of (I). In an example, 600 g. crude (I) was dissolved in 3 l. DMF at 70 degrees C, cooled to 25 degrees C, and treated with 120 ml. 110 vol. H2O2, 480 ml. distilled water, and 60 ml. acetic acid. After 1 hr. the prodt. was filtered off and washed with DMF and acetone to give 540 g. pure (I).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7140137A FR2159176A1 (en) | 1971-11-09 | 1971-11-09 | Purification of vioform - crystallisation of presence of hydrogen peroxide and an acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7140137A FR2159176A1 (en) | 1971-11-09 | 1971-11-09 | Purification of vioform - crystallisation of presence of hydrogen peroxide and an acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2159176A1 true FR2159176A1 (en) | 1973-06-22 |
| FR2159176B3 FR2159176B3 (en) | 1974-06-21 |
Family
ID=9085542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7140137A Granted FR2159176A1 (en) | 1971-11-09 | 1971-11-09 | Purification of vioform - crystallisation of presence of hydrogen peroxide and an acid |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2159176A1 (en) |
-
1971
- 1971-11-09 FR FR7140137A patent/FR2159176A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2159176B3 (en) | 1974-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |