FR2068346A5 - N-acyl 3,4-disubst-phenylalanine derivs - Google Patents
N-acyl 3,4-disubst-phenylalanine derivsInfo
- Publication number
- FR2068346A5 FR2068346A5 FR7038679A FR7038679A FR2068346A5 FR 2068346 A5 FR2068346 A5 FR 2068346A5 FR 7038679 A FR7038679 A FR 7038679A FR 7038679 A FR7038679 A FR 7038679A FR 2068346 A5 FR2068346 A5 FR 2068346A5
- Authority
- FR
- France
- Prior art keywords
- acyl
- disubst
- derivs
- phenylalanine
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 229940125688 antiparkinson agent Drugs 0.000 abstract 1
- 229930016911 cinnamic acid Natural products 0.000 abstract 1
- 235000013985 cinnamic acid Nutrition 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
N-Acyl-3,4-disubst-phenylalanine derivs Title cpds. of formula (I) (where R is 1-4C aliphatic acyl and R1 is 1-4C alkyl or phenyl) which are intermediates for the anti-Parkinson agent 3,4-dihydroxyphenylalanine, are prepd by hydrolysing a cpd. of formula (II) and catalytically hydrogenating the resulting alpha-acylamino-3,4-disubstd- cinnamic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUEE001729 | 1969-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2068346A5 true FR2068346A5 (en) | 1971-08-20 |
Family
ID=10995309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7038679A Expired FR2068346A5 (en) | 1969-10-28 | 1970-10-27 | N-acyl 3,4-disubst-phenylalanine derivs |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT299920B (en) |
| DE (1) | DE2052954A1 (en) |
| FR (1) | FR2068346A5 (en) |
| NL (1) | NL7015213A (en) |
-
1970
- 1970-10-14 AT AT929070A patent/AT299920B/en not_active IP Right Cessation
- 1970-10-16 NL NL7015213A patent/NL7015213A/xx unknown
- 1970-10-27 FR FR7038679A patent/FR2068346A5/en not_active Expired
- 1970-10-28 DE DE19702052954 patent/DE2052954A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7015213A (en) | 1971-05-03 |
| DE2052954A1 (en) | 1971-05-06 |
| AT299920B (en) | 1972-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |