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FR07C0041I2 - Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete - Google Patents

Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete

Info

Publication number
FR07C0041I2
FR07C0041I2 FR07C0041C FR07C0041C FR07C0041I2 FR 07C0041 I2 FR07C0041 I2 FR 07C0041I2 FR 07C0041 C FR07C0041 C FR 07C0041C FR 07C0041 C FR07C0041 C FR 07C0041C FR 07C0041 I2 FR07C0041 I2 FR 07C0041I2
Authority
FR
France
Prior art keywords
pyrazines
beta
amino
tetrahydrotrioazolo
tetrahydroimidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR07C0041C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR07C0041(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR07C0041I1 publication Critical patent/FR07C0041I1/fr
Application granted granted Critical
Publication of FR07C0041I2 publication Critical patent/FR07C0041I2/fr
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
FR07C0041C 2001-07-06 2007-08-27 Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete Active FR07C0041I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (fr) 2001-07-06 2002-07-05 Pyrazines beta-amino tetrahydroimidazo (1, 2-a) et pyrazines tetrahydrotrioazolo (4, 3-a) utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete

Publications (2)

Publication Number Publication Date
FR07C0041I1 FR07C0041I1 (fr) 2007-10-19
FR07C0041I2 true FR07C0041I2 (fr) 2016-09-30

Family

ID=23172273

Family Applications (2)

Application Number Title Priority Date Filing Date
FR07C0041C Active FR07C0041I2 (fr) 2001-07-06 2007-08-27 Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete
FR08C0033C Active FR08C0033I2 (fr) 2001-07-06 2008-08-21 Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR08C0033C Active FR08C0033I2 (fr) 2001-07-06 2008-08-21 Beta-amino-tetrahydroimidazo(1, 2-a)pyrazines et beta-amino-tetrahydrotrioazolo(4, 3-a)pyrazines utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete

Country Status (46)

Country Link
US (9) US6699871B2 (fr)
EP (4) EP2226324A1 (fr)
JP (1) JP3762407B2 (fr)
KR (1) KR100606871B1 (fr)
CN (2) CN1290848C (fr)
AR (1) AR036114A1 (fr)
AT (2) ATE471148T1 (fr)
AU (1) AU2002320303B2 (fr)
BE (1) BE2007C047I2 (fr)
BG (1) BG108493A (fr)
BR (1) BRPI0210866B8 (fr)
CA (1) CA2450740C (fr)
CR (1) CR7235A (fr)
CY (3) CY2007019I2 (fr)
DE (4) DE122008000046I1 (fr)
DK (2) DK1412357T3 (fr)
DO (1) DOP2002000438A (fr)
EA (2) EA012701B1 (fr)
EC (1) ECSP044935A (fr)
ES (2) ES2344846T3 (fr)
FR (2) FR07C0041I2 (fr)
GE (2) GEP20063734B (fr)
HK (1) HK1068882A1 (fr)
HR (1) HRP20031098B1 (fr)
HU (2) HU225695B1 (fr)
IL (3) IL159109A0 (fr)
IS (2) IS2218B (fr)
JO (1) JO2230B1 (fr)
LT (1) LTC1412357I2 (fr)
LU (2) LUC91360I2 (fr)
MA (1) MA27053A1 (fr)
ME (1) ME00439B (fr)
MX (1) MXPA04000018A (fr)
MY (1) MY127961A (fr)
NL (2) NL300287I2 (fr)
NO (4) NO321999B1 (fr)
NZ (1) NZ529833A (fr)
PE (1) PE20030654A1 (fr)
PL (1) PL196278B6 (fr)
PT (2) PT1625847E (fr)
RS (1) RS50737B (fr)
SI (1) SI1412357T1 (fr)
TW (1) TWI226331B (fr)
UA (1) UA74912C2 (fr)
WO (1) WO2003004498A1 (fr)
ZA (1) ZA200309294B (fr)

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JP2005500308A (ja) 2001-06-20 2005-01-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病を治療するためのジペプチジルペプチダーゼ阻害剤
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EP1476178A4 (fr) * 2002-02-14 2009-08-26 Bayer Pharmaceuticals Corp Strategies de formulation dans la stabilisation de peptides dans des solvants organiques et a l'etat seche
US7307164B2 (en) 2002-03-25 2007-12-11 Merck & Co., Inc. β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
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DE60315687T2 (de) * 2002-10-07 2008-06-05 Merck & Co., Inc. Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase
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UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US7307164B2 (en) * 2002-03-25 2007-12-11 Merck & Co., Inc. β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
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