FI971955A0 - Dopamineeristen solujen indusointi in vitro - Google Patents
Dopamineeristen solujen indusointi in vitroInfo
- Publication number
- FI971955A0 FI971955A0 FI971955A FI971955A FI971955A0 FI 971955 A0 FI971955 A0 FI 971955A0 FI 971955 A FI971955 A FI 971955A FI 971955 A FI971955 A FI 971955A FI 971955 A0 FI971955 A0 FI 971955A0
- Authority
- FI
- Finland
- Prior art keywords
- dopamineric
- vitro
- induction
- cells
- dopamineric cells
- Prior art date
Links
- 238000000338 in vitro Methods 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/148—Transforming growth factor alpha [TGF-a]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33909094A | 1994-11-14 | 1994-11-14 | |
US08/482,079 US5981165A (en) | 1991-07-08 | 1995-06-07 | In vitro induction of dopaminergic cells |
PCT/CA1995/000636 WO1996015224A1 (en) | 1994-11-14 | 1995-11-14 | In vitro induction of dopaminergic cells |
Publications (2)
Publication Number | Publication Date |
---|---|
FI971955A0 true FI971955A0 (fi) | 1997-05-07 |
FI971955L FI971955L (fi) | 1997-07-03 |
Family
ID=26991488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971955A FI971955L (fi) | 1994-11-14 | 1997-05-07 | Dopamineeristen solujen indusointi in vitro |
Country Status (10)
Country | Link |
---|---|
US (1) | US5981165A (fi) |
EP (1) | EP0792349A1 (fi) |
JP (2) | JP4023822B2 (fi) |
KR (1) | KR970707270A (fi) |
CN (1) | CN1170434A (fi) |
AU (1) | AU715246B2 (fi) |
CA (1) | CA2204629A1 (fi) |
FI (1) | FI971955L (fi) |
NO (1) | NO321000B1 (fi) |
WO (1) | WO1996015224A1 (fi) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6395494B1 (en) | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
US7544511B2 (en) * | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
US6117911A (en) | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
US20010007657A1 (en) * | 1997-08-04 | 2001-07-12 | Reid James Steven | Compositions and methods for manipulating glial progenitor cells and treating neurological deficits |
US7795202B2 (en) * | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
CN1273534A (zh) * | 1997-08-04 | 2000-11-15 | 加利福尼亚大学董事会 | 治疗神经缺损的方法 |
US20050096274A1 (en) * | 1998-04-07 | 2005-05-05 | Lough John W. | Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis |
US6277820B1 (en) | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
US6787356B1 (en) | 1998-07-24 | 2004-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Cell expansion system for use in neural transplantation |
JP3291698B2 (ja) * | 1998-07-24 | 2002-06-10 | スティーブン・カーティン | 可変眼鏡用レンズ |
EP1109887A4 (en) * | 1998-07-29 | 2003-05-21 | Layton Bioscience Inc | PRODUCTION AND USE OF DOPAMINERGIC CELLS TO TREAT DOPAMINERGIC DEFICIENCIES |
US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US20020168766A1 (en) * | 2000-01-11 | 2002-11-14 | Gold Joseph D. | Genetically altered human pluripotent stem cells |
US6120528A (en) * | 1998-11-03 | 2000-09-19 | Hood Laboratories | Nipple assembly with endoscope |
WO2000047718A1 (en) * | 1999-02-11 | 2000-08-17 | The Salk Institute For Biological Studies | Isolation of stem cells and methods of use thereof |
US20020099008A1 (en) | 1999-04-26 | 2002-07-25 | Daniel R. Twardzik | Method for stimulating hematopoiesis using tgf-alpha |
WO2000065028A2 (en) | 1999-04-26 | 2000-11-02 | Stem Cell Pharmaceuticals, Inc. | TGF-α POLYPEPTIDES, FUNCTIONAL FRAGMENTS AND METHODS OF USE THEREFOR |
AU2004202661B2 (en) * | 1999-05-03 | 2008-04-17 | Neuro Therapeutics Ab | Materials and methods relating to neuronal development |
ES2290032T3 (es) * | 1999-05-03 | 2008-02-16 | Neuro Therapeutics Ab | Procedimiento para la produccion de neuronas dopaminergicas. |
US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
MXPA02001719A (es) * | 1999-08-18 | 2003-09-25 | Childrens Medical Center | METODOS, COMPOSICIONES Y EQUIPOS PARA PROMOVER LA RECUPERACION DEL DAnO AL SISTEMA NERVIOSO CENTRAL. |
US20020193301A1 (en) * | 1999-08-19 | 2002-12-19 | Stem Cell Pharmaceuticals, Inc. | TGF-alpha polypeptides, functional fragments and methods of use therefor |
US6815418B2 (en) * | 1999-08-19 | 2004-11-09 | Kaleidos Pharma, Inc. | TGF-α polypeptides, functional fragments and methods of use therefor |
US6677307B2 (en) | 1999-08-19 | 2004-01-13 | Kaleidos Pharma, Inc. | TGF-α polypeptides, functional fragments and methods of use therefor |
US7455983B2 (en) * | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
US20050042749A1 (en) * | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
US6395546B1 (en) * | 2000-02-01 | 2002-05-28 | Neurogeneration, Inc. | Generation of dopaminergic neurons from human nervous system stem cells |
AU3499801A (en) * | 2000-02-11 | 2001-08-20 | Schepens Eye Res Inst | Isolation and transplantation of retinal stem cells |
ATE342723T1 (de) | 2000-04-13 | 2006-11-15 | Univ Texas | Behandlung von neurodegenerativen gastrointestinalen krankheiten durch implantation von neuralen stammzellen und/oder deren nachkommen in gastrointestinalorgane |
US7250294B2 (en) * | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
JP5943533B2 (ja) * | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
US6897061B1 (en) | 2000-06-16 | 2005-05-24 | Spinal Cord Society | Transdifferentiation of glial cells |
US20020077291A1 (en) * | 2000-09-22 | 2002-06-20 | Alan Upshall | Method of treatment of tumors using transforming growth factor-alpha |
US20020192194A1 (en) * | 2000-12-05 | 2002-12-19 | Mcgrogan Michael | Production and use of dopaminergic cells to treat dopaminergic deficiencies |
US7838292B1 (en) * | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
WO2002083877A1 (en) * | 2001-04-11 | 2002-10-24 | Stem Cell Therapeutics Inc. | Production of tyrosine hydroxylase positive neurons |
US20040247571A1 (en) * | 2001-04-23 | 2004-12-09 | Xia Meijer | Neural cells expressing tyrosine hydroxylase |
US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
ATE411019T1 (de) * | 2001-05-02 | 2008-10-15 | Brni Neurosciences Inst | Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung |
AU2002324645C1 (en) * | 2001-08-08 | 2008-11-06 | Levesque Biosciences, Inc. | Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof |
US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
US20080004332A1 (en) * | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
JP4439396B2 (ja) * | 2002-06-24 | 2010-03-24 | 田辺三菱製薬株式会社 | 神経系細胞の製造方法 |
US7622270B2 (en) | 2002-10-22 | 2009-11-24 | Eisai R&D Management Co., Ltd. | Methods of isolating dopaminergic neuron precursor cells |
US20040214324A1 (en) * | 2002-12-09 | 2004-10-28 | Ole Isacson | Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases |
EP1608728A2 (en) * | 2003-03-31 | 2005-12-28 | University Of South Florida Research Foundation, Inc. | Materials and methods for regulating process formation in cell culture |
ITRM20030376A1 (it) * | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
DE602004030809D1 (de) * | 2003-09-12 | 2011-02-10 | Stemcell Technologies Inc | Test für neurale koloniebildung |
US20070269412A1 (en) | 2003-12-02 | 2007-11-22 | Celavie Biosciences, Llc | Pluripotent cells |
CA2547827C (en) * | 2003-12-02 | 2015-02-03 | Catholic Healthcare West | Compositions and methods for propagation of neural progenitor cells |
TW200538181A (en) * | 2004-05-18 | 2005-12-01 | Brni Neurosciences Inst | Treatment of depressive disorders |
JP3996627B2 (ja) | 2004-07-22 | 2007-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Lrp4/Corinドーパミン産生ニューロン前駆細胞マーカー |
US20060069009A1 (en) * | 2004-09-28 | 2006-03-30 | Messina Darin J | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
JP5424559B2 (ja) * | 2004-11-17 | 2014-02-26 | ニューラルステム・インコーポレーテッド | 神経変性状態を治療するためのヒト神経細胞の移植 |
CA2617003A1 (en) | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
US20100093089A1 (en) * | 2006-11-09 | 2010-04-15 | Eduardo Marban | Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells |
EP2121000B1 (en) | 2007-02-09 | 2015-09-23 | Blanchette Rockefeller Neurosciences, Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
US8338176B2 (en) * | 2007-07-30 | 2012-12-25 | The Board Of Trustees Of The Leland Stanford Junior University | Derivation of neural stem cells from embryonic stem cells |
US9101570B1 (en) | 2009-02-13 | 2015-08-11 | Endocellutions, Inc. | Adult and neonatal stem cell therapy to treat diabetes through the repair of the gastrointestinal tract |
US20100209399A1 (en) * | 2009-02-13 | 2010-08-19 | Celavie Biosciences, Llc | Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects |
GB0908934D0 (en) * | 2009-05-26 | 2009-07-01 | Univ The West Of Scotland | Differentiation medium |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
JP6077996B2 (ja) | 2010-07-28 | 2017-02-08 | ニューラルステム, インコーポレイテッド | 神経変性性疾患および/または障害を処置および/または逆転させるための方法 |
CA2836465A1 (en) * | 2011-05-17 | 2012-11-22 | University Of Central Florida Research Foundation, Inc. | Stable electrically active neurons from adult tissue |
CN103031335A (zh) * | 2011-10-09 | 2013-04-10 | 李川源 | 直接从人成纤维细胞诱导产生多巴胺样神经元的方法及应用 |
WO2013123292A1 (en) | 2012-02-17 | 2013-08-22 | The Schepens Eye Research Institute | Phenotype profile of human retinal progenitor cells |
WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
CA2881394C (en) | 2012-08-13 | 2024-05-14 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
JP6878274B2 (ja) | 2014-10-03 | 2021-05-26 | シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center | 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム |
KR20190060016A (ko) | 2014-10-20 | 2019-05-31 | 뉴럴스템, 인크. | 성장 인자를 코딩하는 외인성 폴리뉴클레오티드를 포함하는 안정한 신경 줄기세포 및 그의 사용 방법 |
US10520493B2 (en) * | 2015-03-13 | 2019-12-31 | National Cheng Kung University | Method for assessment of neural function by establishing analysis module |
WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
US5411883A (en) * | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
WO1991009936A1 (en) * | 1989-12-26 | 1991-07-11 | Hana Biologics, Inc. | Proliferated neuron progenitor cell product and process |
WO1993001275A1 (en) * | 1991-07-08 | 1993-01-21 | Neurospheres Ltd. | NOVEL GROWTH FACTOR-RESPONSIVE PROGENITOR CELLS WHICH CAN BE PROLIFERATED $i(IN VITRO) |
ATE275197T1 (de) * | 1991-09-20 | 2004-09-15 | Amgen Inc | Glial neurotrophe faktor |
AU4995193A (en) * | 1992-08-04 | 1994-03-03 | Regeneron Pharmaceuticals, Inc. | Method of enhancing differentiation and survival of neuronal precursor cells |
ATE234353T1 (de) * | 1992-10-28 | 2003-03-15 | Neurospheres Holdings Ltd | Biologische faktoren und neuronale stammzellen |
-
1995
- 1995-06-07 US US08/482,079 patent/US5981165A/en not_active Expired - Fee Related
- 1995-11-14 WO PCT/CA1995/000636 patent/WO1996015224A1/en not_active Application Discontinuation
- 1995-11-14 JP JP51559996A patent/JP4023822B2/ja not_active Expired - Fee Related
- 1995-11-14 CN CN95196843A patent/CN1170434A/zh active Pending
- 1995-11-14 KR KR1019970703244A patent/KR970707270A/ko not_active Withdrawn
- 1995-11-14 EP EP95936392A patent/EP0792349A1/en not_active Withdrawn
- 1995-11-14 AU AU38366/95A patent/AU715246B2/en not_active Ceased
- 1995-11-14 CA CA002204629A patent/CA2204629A1/en not_active Abandoned
-
1997
- 1997-05-07 FI FI971955A patent/FI971955L/fi not_active Application Discontinuation
- 1997-05-12 NO NO19972170A patent/NO321000B1/no unknown
-
2007
- 2007-02-22 JP JP2007041989A patent/JP2007135604A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JPH10509319A (ja) | 1998-09-14 |
NO972170L (no) | 1997-06-30 |
WO1996015224A1 (en) | 1996-05-23 |
EP0792349A1 (en) | 1997-09-03 |
JP4023822B2 (ja) | 2007-12-19 |
AU715246B2 (en) | 2000-01-20 |
JP2007135604A (ja) | 2007-06-07 |
NO972170D0 (no) | 1997-05-12 |
NO321000B1 (no) | 2006-02-27 |
CA2204629A1 (en) | 1996-05-23 |
KR970707270A (ko) | 1997-12-01 |
FI971955L (fi) | 1997-07-03 |
MX9703493A (es) | 1997-10-31 |
US5981165A (en) | 1999-11-09 |
AU3836695A (en) | 1996-06-06 |
CN1170434A (zh) | 1998-01-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI971955A0 (fi) | Dopamineeristen solujen indusointi in vitro | |
FI970026L (fi) | Nisäkästelomeraasi | |
FI963513A (fi) | Geenien rinnakkainen ilmentäminen in vivo | |
DE69322573D1 (de) | Zellkultureinsatz | |
DE69319983D1 (de) | Zellkultureinsatz | |
NO982710D0 (no) | Dilator med avskrellingskraftreduksjon | |
DE59505847D1 (de) | Pseudoceramide | |
DE69617583D1 (de) | In vitrozellkultur-System | |
DE69526002D1 (de) | Aufladegerät und Aufladevorrichtung | |
EP0797450A4 (en) | In vitro t-lymphopoiesis system | |
DE59501655D1 (de) | Direktumrichter | |
DE69522404D1 (de) | Aufladevorrichtung | |
DE69514758D1 (de) | Wägezellen | |
FI972010A0 (fi) | Arrangemang i en borrningsanordning | |
KR950031586U (ko) | 급속 및 일반 충전회로 | |
FI940862A0 (fi) | Cell med skiktstruktur | |
KR970049661U (ko) | 인버터의 케이스 | |
FI1769U1 (fi) | Uppsamlingsram foer skraep och hushaollsavfaell | |
KR960006251U (ko) | 마그네트론에서의 폴피스 결합구조 | |
BR7400422U (pt) | Disposição introduzida em guarda-sol | |
BR9403633A (pt) | Células indutivas diferenciadas | |
KR950022452U (ko) | 청국장 발효기 | |
UA475S (uk) | Зарядний пристрій | |
SE9402203D0 (sv) | High power battery and its manufacture | |
FI1691U1 (fi) | Hopsaettningsmaskin foer lastpallsben |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |